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RAP1GAP2 encodes a GTPase-activating protein that activates the small guanine-nucleotide-binding protein Rap1 in platelets.
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Rap1GAP2 is the first GTPase-activating protein of Rap1 found in platelets and is likely to have an important regulatory role in platelet aggregation
Platelet activation by ADP and thrombin (show F2 ELISA Kits) enhances serine 9 phosphorylation and increases 14-3-3 (show YWHAQ ELISA Kits) binding to endogenous Rap1GAP2.
Slp1 inhibits dense granule secretion in platelets and that Rap1GAP2 modulates secretion by binding to Slp1.
Rap1gap2 overexpression limits neurite outgrowth and branching in Neuro-2a cells, and counteracts Rap1-induced augmentation of neurite outgrowth
This gene encodes a GTPase-activating protein that activates the small guanine-nucleotide-binding protein Rap1 in platelets. The protein interacts with synaptotagmin-like protein 1 and Rab27 and regulates secretion of dense granules from platelets at sites of endothelial damage. Multiple transcript variants encoding different isoforms have been found for this gene.
GTPase activating RANGAP domain-like 4
, GTPase activating Rap/RanGAP domain-like 4
, GTPase-activating Rap/Ran-GAP domain-like protein 4
, rap1 GTPase-activating protein 2