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a Ras-related small GTP-binding protein that is found in high levels in neuronal tissues [RGD, Feb 2006].. Additionally we are shipping REM2 Proteins (4) and and many more products for this protein.
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Our results highlight Rem2 as a unique molecule that transduces changes in neuronal activity detected at the cell membrane to morphologically relevant changes in gene expression in the nucleus
Study have shown that Rem2 is expressed in a variety of nervous system tissues, but is enriched in the basal ganglia. The function of Rem2 in the basal ganglia is unknown, but may be important for neuronal maturation during development, and/or neuroplasticity in adulthood.
Nuclear localization of RGK proteins (Rad (show RRAD Antibodies), Rem (show REM1 Antibodies), and Rem2) contributes to the suppression of RGK-mediated cell shape remodeling.
Voltage dependant calcium channels blockade by Rem2 is likely to be controlled by both the localized concentration of membrane phosphorylated phosphatidylinositide lipids and direct 14-3-3 (show YWHAQ Antibodies) binding to the Rem2 C-terminus.
conclude that endogenous Rem2 is a positive regulator of functional, excitatory synapse development and a negative regulator of dendritic complexity
Rem2 has a role in neuronal plasticity hrough co-trafficking with CaMKIIa
molecular mechanisms by which Rem2 knockdown affected synaptogenesis and Ca(2 (show CA2 Antibodies)) homeostasis in cultured rat hippocampal neurons
our results suggest that Rem2 regulates dendritic branching and synapse development
Rem2 mediates the fibroblastic growth factor 2 (FGF2) signaling pathway to maintain proliferation of hESCsby suppressing the transcriptional activity of p53 and cyclin D(1)
inhibition of L-type Ca2 (show CA2 Antibodies)+ channels by Rem2 signaling may represent a new and potentially important mechanism for regulating Ca2 (show CA2 Antibodies)+-triggered exocytosis in hormone-secreting cells, including insulin (show INS Antibodies) secretion in pancreatic beta-cells
data unravel a possible molecular mechanism for Rem2-induced angiogenesis and suggests Rem2 as a potential novel target for treating pathological angiogenesis
a Ras-related small GTP-binding protein that is found in high levels in neuronal tissues
RAS (RAD and GEM)-like GTP binding 2
, GTP-binding protein REM 2
, rad and Gem-like GTP-binding protein 2
, GEM, REM, Kir family small G-protein
, GTP-binding protein REM2
, Ras-related GTP-binding protein of the Rad/Gem/Kir family member 2
, Ras-related GTP-binding protein of the Rad/Gem/Kir family, member 2
, rad and gem related GTP binding protein 2
, Rad and Gem-related 2 (rat homolog)