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RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Additionally we are shipping and many more products for this protein.
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Human Polyclonal RBM25 Primary Antibody for IP, WB - ABIN252843
Maubach, Lim, Zhuo: Nuclear cathepsin F regulates activation markers in rat hepatic stellate cells. in Molecular biology of the cell 2008
Show all 2 Pubmed References
Data suggest that RBM25 is required for the viability of multiple human cell lines, suggesting that it could play a key role in pre-mRNA splicing; a region of RBM25 spanning Lys77 binds with high affinity to SRSF2 (show SRSF2 Antibodies), a crucial protein in exon definition, but only when Lys77 is unmethylated. (RBM25 = RNA binding motif protein 25; SRSF2 (show SRSF2 Antibodies) = serine- and arginine-rich splicing factor 2 (show SRSF1 Antibodies))
Structure-guided mutagenesis reveals a positively charged nucleic-acid-binding surface in the RBM25 PWI (show WRB Antibodies) domain
RBM25/LUC7L3 (show LUC7L3 Antibodies)-mediated abnormal SCN5A (show SCN5A Antibodies) mRNA splicing reduced Na+ channel current 91.1+/-9.3% to a range known to cause sudden death.
RED120 may function to couple splicing with mRNA 3'-end formation.
These data suggest a novel mode for Bcl-x (show BCL2L1 Antibodies)(S) 5' ss activation in which binding of RBM25 with exonic element CGGGCA may stabilize the pre-mRNA-U1 snRNP (show LSM2 Antibodies) through interactions with hLuc7A (show LUC7L3 Antibodies).
RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA (By similarity).
RNA-binding protein 25
, RNA binding motif protein 25
, RNA-binding protein 25-like
, Arg/Glu/Asp-rich protein, 120 kDa
, RNA-binding motif protein 25
, RNA-binding region (RNP1, RRM) containing 7
, RNA-binding region-containing protein 7
, U1 small nuclear ribonucleoprotein 1SNRP homolog
, arg/Glu/Asp-rich protein of 120 kDa
, functional spliceosome-associated protein 94