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RBM8A encodes a protein with a conserved RNA-binding motif.
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Results demonstrated that RBM8A is highly expressed in hepatocellular carcinoma (HCC (show FAM126A Proteins)), and patients with lower RBM8A expression level had longer overall survival and progression free survival. Also, results indicate that RBM8A promotes invasion and metastasis via epithelial-mesenchymal transition signaling pathway.
Y14 may selectively and differentially modulate protein biosynthesis.
this data suggests a novel role of RBM8a in the regulation of neurodevelopment.
Mutations of RBM8A and TBX6 (show TBX6 Proteins) are associated with disorders of the mullerian ducts.
It was demonstrated that Rbm8a is an essential neurogenesis regulator in embryonic cortical development.
Depletion of RNA-binding protein (show PTBP1 Proteins) RBM8A (Y14) causes cell cycle deficiency and apoptosis in human tumor cells.
Y14 positively regulates signals for TNF-alpha (show TNF Proteins)-induced IL-6 (show IL6 Proteins) production at multiple steps beyond an exon junction complex protein.
Y14 mutants, which are deficient in binding to Magoh (show MAGOH Proteins), could still be localized to the nucleus, suggesting the existence of both the nuclear import pathway and function for Y14 unaccompanied by Magoh (show MAGOH Proteins)
Data show that Y14 interacts directly with the decapping factor Dcp2 (show DCP2 Proteins) and the 5' cap structure of mRNAs via different but overlapping domains.
findings show that the two regulatory SNPs result in diminished RBM8A transcription in vitro and that Y14 expression is reduced in platelets from individuals with thrombocytopenia with absent radii (TAR)
our data demonstrate that miR (show MLXIP Proteins)-29a regulates the proliferation and differentiation of RPCs by directly targeting Rbm8a, providing us with a better understanding of the molecular mechanisms that govern RPC (show RTCD1 Proteins) proliferation and differentiation.
Data suggest that, in embryonic stem cells, Gsk3b/Gsk3a (show GSK3a Proteins) phosphorylate splicing factors (Rbm8a, Srsf9 (show SFRS9 Proteins), and Psf (show IL-3 Proteins)) and nucleolar proteins (Npm1 (show GJA1 Proteins) and Phf6 (show PHF6 Proteins)); Gsk3b/Gsk3a (show GSK3a Proteins) are key to alternative splicing of close to 190 genes. (Gsk3 = glycogen synthase kinase-3 (show GSK3a Proteins); Rbm8a = RNA binding motif protein 8a; Srsf9 (show SFRS9 Proteins) = splicing factor (show SLU7 Proteins), arginine-serine-rich 9; Psf (show IL-3 Proteins) = replication protein Psf (show IL-3 Proteins); Npm1 (show GJA1 Proteins) = nucleophosmin 1 (show NPM1 Proteins); Phf6 (show PHF6 Proteins) = PHD finger protein 6 (show PHF6 Proteins))
we first show that Eif4a3 (show EIF4A3 Proteins) haploinsufficiency phenocopies aberrant neurogenesis and microcephaly of Magoh (show MAGOH Proteins) and Rbm8a mutant mice.we show that genetic ablation of one downstream pathway, p53 (show TP53 Proteins), significantly rescues microcephaly of all 3 EJC mutant
This is the first study that demonstrates the key role of RBM8a on the emotional behaviors in mice.
This gene encodes a protein with a conserved RNA-binding motif. The protein is found predominantly in the nucleus, although it is also present in the cytoplasm. It is preferentially associated with mRNAs produced by splicing, including both nuclear mRNAs and newly exported cytoplasmic mRNAs. It is thought that the protein remains associated with spliced mRNAs as a tag to indicate where introns had been present, thus coupling pre- and post-mRNA splicing events. Previously, it was thought that two genes encode this protein, RBM8A and RBM8B\; it is now thought that the RBM8B locus is a pseudogene. Two alternative start codons result in two forms of the protein, and this gene also uses multiple polyadenylation sites.
RNA binding motif protein 8A
, RNA-binding motif protein 8A
, RNA-binding protein 8A
, Ribonucleoprotein RBM8A
, RNA binding motif protein 8B
, RNA-binding protein Y14
, binder of OVCA1-1
, ribonucleoprotein RBM8
, ribonucleoprotein RBM8A
, RNA binding motif protein 8
, RNA-binding motif protein 8A-A
, RNA-binding protein 8A-A
, Ribonucleoprotein RBM8A-A