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Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. Additionally we are shipping REG4 Kits (57) and REG4 Proteins (23) and many more products for this protein.
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Reg4 inhibited apoptosis through regulating MAPK/Erk (show MAPK1 Antibodies)/Bim (show BCL2L11 Antibodies) signaling pathway and thereby enhanced the resistance of gastric cancer to 5-Fluorouracil.
Data indicate that REG4 tissue expression is a prognostic marker in subgroups of pancreatic ductal adenocarcinoma patients, and Serum REG4 level might be useful in differential diagnosis between pancreatic ductal adenocarcinoma and chronic pancreatitis.
REG4 promotes peritoneal metastasis of gastric cancer through GPR37 (show GPR37 Antibodies) and triggers a positive feedback loop.
Study demonstrated that REG4, which is overexpressed in pancreatic ductal adenocarcinoma and secreted by cancer cells, promoted macrophage polarization to M2, through at least in part, activation of ERK1/2 and CREB (show CREB1 Antibodies).
REG4 is a transcriptional target of GATA6 (show GATA6 Antibodies) and is essential for colorectal tumorigenesis.
This study identifies REG4 as a potential serum biomarker for histotype-specific detection of mucinous ovarian cancer and suggests serum REG4 measurement as a non-invasive diagnostic tool for follow-up of patients with mucinous ovarian cancer.
aberrant REG4 expression plays an essential role in early ovarian carcinogenesis and is closely linked to mucinous ovarian tumors, differentiation and adverse prognosis of ovarian cancer by modulating proliferation, apoptosis, migration and invasion.
REG4 expression associated with favorable clinicopathological parameters and with higher overall survival from non-mucinous
The Reg IV may be involved in the finetuning of functions exerted by the neuroendocrine cells in the GI-tract.
Colorectal tumor patients with Reg4- and MMP-7 (show MMP7 Antibodies)-positive tumors had extremely poor overall survival.
sorted Reg4(+) DCS cells promote organoid formation of single Lgr5 (show LGR5 Antibodies)(+) colon stem cells. DCS cells can be massively produced from Lgr5 (show LGR5 Antibodies)(+) colon stem cells in vitro by combined Notch (show NOTCH1 Antibodies) inhibition and Wnt (show WNT2 Antibodies) activation
data suggest that Reg4 may protect against acinar cell necrosis in experimental pancreatitis by enhancing the expression of Bcl-2 (show BCL2 Antibodies) and Bcl-xL (show BCL2L1 Antibodies) via activation of the EGFR (show EGFR Antibodies)/Akt (show AKT1 Antibodies) signalling pathway.
Reg IV as an important modulator of gastrointestinal cell susceptibility to irradiation; hence, it is a potential target for adjunctive treatments for human colorectal cancer and other gastrointestinal malignancies.
reg4 is amplified in the early stages of pancreatic cancer development
Cloning and characterization of human REG4/RELP, in addition to cloning of mouse Reg4.
Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium (By similarity).
, regenerating islet-derived protein 4
, REG-like protein
, gastrointestinal secretory protein
, reg IV
, regenerating gene type IV
, regenerating islet-derived protein IV