Rh Family C Glycoprotein Proteins (RHCG)

Functions as an electroneutral and bidirectional ammonium transporter. Additionally we are shipping Rh Family C Glycoprotein Antibodies (89) and Rh Family C Glycoprotein Kits (14) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RHCG 51458 Q9UBD6
RHCG 56315 Q9QXP0
Rat RHCG RHCG 293048 Q7TNN9
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top Rh Family C Glycoprotein Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg 50 to 55 Days
$5,262.31
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg 50 to 55 Days
$7,493.38
Details
Wheat germ Human GST tag 2 μg 11 to 12 Days
$338.33
Details

RHCG Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Rh Family C Glycoprotein (RHCG) Interaction Partners

Human Rh Family C Glycoprotein (RHCG) interaction partners

  1. RhCG and H+ATPases are located within the same cellular protein complex in the kidney and this interaction is required for maximal urinary acidification by H+-ATPases, a prerequisite for efficient NH3 secretion and urine excretion of NH4+.

  2. RHCG was down-regulated in cervical cancers compared to that in normal cervical tissues, and further decreased in cervical cancer cell lines. Functionally, RHCG overexpression reduced cervical cancer cell proliferation and migration, as evidenced by the decreased transforming growth factor (TGF)-beta1, matrix metalloproteinase (MMP)-2 and MMP-9 expressions in cancer cells.

  3. The results support the notion that RHCG is a novel tumor suppressor gene that plays an important role in the development and progression of ESCC.

  4. The molecular mechanism of NH4(+) recruitment and NH3 transport by RHCG is described.

  5. Rh B Glycoprotein (Rhbg) and Rh C Glycoprotein (Rhcg) are identified as ammonia transporters. They are expressed in specific cell populations and membrane domains in distal renal epithelial cells, where they facilitate ammonia secretion.

  6. RhAG, RhBG and RhCG-exhibit significant permeability to NH3 and show for the first time that RhBG and RhCG can conduct CO2.

  7. Amt and Rh proteins are not functionally equivalent and that permeation takes place according to two distinct mechanisms.

  8. X-ray crystallographic structure of human RhCG, determined at 2.1 A resolution, reveals the mechanism of ammonia transport.

  9. major finding of this study is that RhCG protein is active as an NH(3) channel and that this function does not require any protein partner

  10. RhBG and RhCG facilitate ammonium movement across the plasma membrane; these results favor the hypothesis that these Rh glycoproteins, together with their homolog RhAG, constitute a family of NH3 channels in mammalian cells.

  11. RhCG expression enhanced the ammonium-induced initial alkalinization (related to NH3 influx)& secondary acidification (related to NH4+ influx). Sub-millimolar NH4+ concentrations induced inward currents in voltage-clamped RhCG-expressing cells.

  12. Review. Mutations at positions F74, V137 and F235 resulted in a severe reduction of NH3 transport.

  13. This study concludes that under normal conditions, RhCG is the major putative ammonia transporter expressed in the human kidney and RhBG is not expressed at detectable levels.

  14. Rhbg and Rhcg may contribute to bronchial epithelial cell ammonia metabolism and suggest that they do not contribute to pulmonary carbon dioxide transport.

Mouse (Murine) Rh Family C Glycoprotein (RHCG) interaction partners

  1. RhCG and H+ATPases are located within the same cellular protein complex in the kidney and this interaction is required for maximal urinary acidification by H+-ATPases, a prerequisite for efficient NH3 secretion and urine excretion of NH4+.

  2. We characterized ammonia and ammonium (NH3/NH4 (+)) transport by the rhesus-associated (Rh) glycoproteins RhAG, Rhbg, and Rhcg expressed in Xenopus oocytes. We used ion-selective microelectrodes and two-electrode voltage clamp to measure changes in intracellular pH, surface pH, and whole cell currents induced by NH3/NH4 (+) and methyl amine/ammonium (MA/MA(+)).

  3. investigated the renal adaptive response of acid excretory pathways to high-protein diets containing normal or low amounts of acid-producing sulfur amino acids (SAA) and examined how this adaption requires the RhCG ammonia transporter

  4. Rh B Glycoprotein (Rhbg) and Rh C Glycoprotein (Rhcg) are identified as ammonia transporters. They are expressed in specific cell populations and membrane domains in distal renal epithelial cells, where they facilitate ammonia secretion.

  5. Rhcg is critically important in the renal response to metabolic acidosis. in mice with intact Rhcg expression, metabolic acidosis does not induce maximal changes in PEPCK, NHE-3, and GS expression despite the presence of persistent metabolic acidosis.

  6. highly expressed in specific cells in the male reproductive tract

  7. hypokalemia increases collecting duct Rhcg expression, and this likely contributes to the hypokalemia-stimulated increase in urinary ammonia excretion, and its adaptive increases in phosphate-dependent glutaminase expression can compensate for the absence of collecting duct Rhcg.

  8. Rhcg is critical for apical and basolateral ammonia transport in the mouse collecting duct

  9. Rhcg expression in intercalated cells is necessary for the normal renal response to metabolic acidosis, contributing to both basal and acidosis-stimulated ammonia excretion. Adaptations in Rhbg expression occur in response to acid-loading.

  10. Localization of the ammonium transporter proteins RhBG and RhCG in mouse kidney.

  11. RhBG and RhCG are present in a major site of ammonia secretion in the kidney, i.e., the CNT and CD, in agreement with their putative role in ammonium transport.

  12. RhCG immunoreactivity is present in bile duct epithelial cells, where it may contribute to ammonium secretion into bile fluid.

  13. The expression of the ammonia transporter family members Rh B glycoprotein (RhBG) and Rh C glycoprotein (RhCG) in the mouse gastrointestinal tract.

  14. These results strongly suggest that RhBG and RhCG transport ammonia by an electroneutral process that involves NH4(+)/H+ exchange resulting in net NH3 translocation.

  15. RhCG-mediated transport is an electroneutral process that is driven by the NH4+ concentration and the transmembrane H+ gradient, effectively exchanging NH4+ for H+ in a process that results in transport of net NH3.

  16. Review. Animal studies show Rhcg has a role in transmembrane NH3 or NH4+ transport in epithelial cells.

  17. Review. Renal RhCG belongs to the Mep/Amt family of ammonium transporters & promotes bi-directional ammonium transport upon heterologous expression in yeast. Its role in ammonium excretion is being studied in knockout mice.

  18. Review. In kidney, Rhcg immunoreactivity is exclusively apical. Rhcg is present in bile duct epithelia. In the gastrointestinal tract, Rhcg exhibits cell-specific, axially heterogeneous, and polarized expression.

  19. RhCG expression enhanced the ammonium-induced initial alkalinization (related to NH3 influx)& secondary acidification (related to NH4+ influx). Sub-millimolar NH4+ concentrations induced inward currents in voltage-clamped RhCG-expressing cells.

  20. a critical role for Rhcg in ammonium handling and pH homeostasis both in the kidney and the male reproductive tract

Zebrafish Rh Family C Glycoprotein (RHCG) interaction partners

  1. is required to facilitate normal ammonia excretion in the zebrafish larva

Rh Family C Glycoprotein (RHCG) Protein Profile

Protein Summary

Functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial ammonia secretion.

Gene names and symbols associated with RHCG

  • Rh family C glycoprotein (RHCG)
  • Rh type C glycoprotein (LOC445729)
  • Rhesus blood group-associated C glycoprotein (Rhcg)
  • Rh family, C glycoprotein (Rhcg)
  • Rh family C glycoprotein S homeolog (rhcg.S)
  • Rh family, C glycoprotein b (rhcgb)
  • BB065800 protein
  • C15ORF6 protein
  • pdrc2 protein
  • rhcg protein
  • rhcgl2 protein
  • rhgk protein
  • slc42a3 protein
  • zgc:77520 protein

Protein level used designations for RHCG

Rh type C glycoprotein , Rhesus blood group, C glycoprotein , ammonium transporter Rh type C , rh family type C glycoprotein , rh glycoprotein kidney , rhesus blood group family type C glycoprotein , tumor-related protein DRC2 , rhesus-associated C glycoprotein , Rhesus blood group-associated C glycoprotein , Rhesus type C glycoprotein , rh type C glycoprotein , ammonia transporter RhCG , Rhesus blood group, C glycoprotein b , ammonium transporter Rh type C-like 2 , drRhcg1 , rh family type C glycoprotein-like 2 , rhesus blood group family type C glycoprotein-like 2

GENE ID SPECIES
51458 Homo sapiens
281456 Bos taurus
415490 Gallus gallus
453638 Pan troglodytes
479040 Canis lupus familiaris
664731 Macaca mulatta
445729 Ciona intestinalis
56315 Mus musculus
293048 Rattus norvegicus
733644 Sus scrofa
100009494 Oryctolagus cuniculus
100528009 Ovis aries
792274 Danio rerio
Selected quality suppliers for Rh Family C Glycoprotein Proteins (RHCG)
Did you look for something else?