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Functions as an electroneutral and bidirectional ammonium transporter. Additionally we are shipping Rh Family C Glycoprotein Antibodies (84) and Rh Family C Glycoprotein Kits (13) and many more products for this protein.
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The molecular mechanism of NH4(+) recruitment and NH3 transport by RHCG is described.
Rh B Glycoprotein (Rhbg) and Rh C Glycoprotein (Rhcg) are identified as ammonia transporters. They are expressed in specific cell populations and membrane domains in distal renal epithelial cells, where they facilitate ammonia secretion.
RhAG (show RHAG Proteins), RhBG and RhCG-exhibit significant permeability to NH3 and show for the first time that RhBG and RhCG can conduct CO2.
Amt (show AMT Proteins) and Rh proteins are not functionally equivalent and that permeation takes place according to two distinct mechanisms.
X-ray crystallographic structure of human RhCG, determined at 2.1 A resolution, reveals the mechanism of ammonia transport.
major finding of this study is that RhCG protein is active as an NH(3) channel and that this function does not require any protein partner
RhBG and RhCG facilitate ammonium movement across the plasma membrane; these results favor the hypothesis that these Rh glycoproteins, together with their homolog RhAG (show RHAG Proteins), constitute a family of NH3 channels in mammalian cells.
RhCG expression enhanced the ammonium-induced initial alkalinization (related to NH3 influx)& secondary acidification (related to NH4+ influx). Sub-millimolar NH4+ concentrations induced inward currents in voltage-clamped RhCG-expressing cells.
This study concludes that under normal conditions, RhCG is the major putative ammonia transporter expressed in the human kidney and RhBG is not expressed at detectable levels.
Rhbg and Rhcg may contribute to bronchial epithelial cell ammonia metabolism and suggest that they do not contribute to pulmonary carbon dioxide transport.
We characterized ammonia and ammonium (NH3/NH4 (+)) transport by the rhesus-associated (Rh) glycoproteins RhAG, Rhbg, and Rhcg expressed in Xenopus oocytes. We used ion-selective microelectrodes and two-electrode voltage clamp to measure changes in intracellular pH, surface pH, and whole cell currents induced by NH3/NH4 (+) and methyl amine/ammonium (MA/MA(+)).
investigated the renal adaptive response of acid excretory pathways to high-protein diets containing normal or low amounts of acid-producing sulfur amino acids (SAA (show SAA1 Proteins)) and examined how this adaption requires the RhCG ammonia transporter
Rhcg is critically important in the renal response to metabolic acidosis. in mice with intact Rhcg expression, metabolic acidosis does not induce maximal changes in PEPCK (show PEPCK Proteins), NHE-3 (show SLC9A3 Proteins), and GS expression despite the presence of persistent metabolic acidosis.
hypokalemia increases collecting duct Rhcg expression, and this likely contributes to the hypokalemia-stimulated increase in urinary ammonia excretion, and its adaptive increases in phosphate-dependent glutaminase (show GLS2 Proteins) expression can compensate for the absence of collecting duct Rhcg.
Rhcg is critical for apical and basolateral ammonia transport in the mouse collecting duct
Rhcg expression in intercalated cells is necessary for the normal renal response to metabolic acidosis, contributing to both basal and acidosis-stimulated ammonia excretion. Adaptations in Rhbg expression occur in response to acid-loading.
Localization of the ammonium transporter proteins RhBG and RhCG in mouse kidney.
RhBG and RhCG are present in a major site of ammonia secretion in the kidney, i.e., the CNT and CD, in agreement with their putative role in ammonium transport.
RhCG immunoreactivity is present in bile duct epithelial cells, where it may contribute to ammonium secretion into bile fluid.
Functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial ammonia secretion.
ammonia transporter RhCG
, ammonium transporter Rh type C
, Rh type C glycoprotein
, Rhesus blood group, C glycoprotein
, rh family type C glycoprotein
, rh glycoprotein kidney
, rhesus blood group family type C glycoprotein
, tumor-related protein DRC2
, Rhesus blood group-associated C glycoprotein
, Rhesus type C glycoprotein
, rh type C glycoprotein
, rhesus-associated C glycoprotein