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RNF41 encodes an E3 ubiquitin ligase.
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Data (including data from studies using knockout and transgenic mice/cells) suggest that CLEC16A, NRDP1, and USP8 (show USP8 Proteins) form tripartite complex; CLEC16A-NRDP1-USP8 (show USP8 Proteins) complex appears to rely on ubiquitin signals to promote mitophagy and maintain mitochondrial function necessary for beta-cell function. (CLEC16A = C-type lectin domain family 16 member A; NRDP1 = ubiquitin-protein ligase (show UBE2K Proteins) NRDP1; USP8 (show USP8 Proteins) = ubiquitin specific peptidase 8 (show USP8 Proteins))
Over-expression of miR (show MLXIP Proteins)-497 promotes the proliferation of glioma cells U87 by targeting Nrdp1.
Authors conclude that the planar cell polarity (PCP (show PRCP Proteins)) pathway contributes significantly to the motility and hence the invasiveness of glioblastoma multiforme (GBM) cells, and that Nrdp1 acts as a negative regulator of PCP (show PRCP Proteins) signaling by inhibiting Dvl (show DVL2 Proteins) through a novel polyubiquitination mechanism.
Data suggest that PHLPP1 plays an important role in assembly of kinetochores by counteracting RNF41-mediated SGT1 (show SUGT1 Proteins) degradation. (PHLPP1 = PH domain and leucine rich repeat protein phosphatase 1; RNF41 = ring finger protein 41; SGT1 (show SUGT1 Proteins) = suppressor of G2 allele of SKP1 (show SUGT1 Proteins))
Results show low expression level of NRDP1 in colorectal neoplasm independently of tumor stage.
findings suggest that HBx promotes the progression of hepatocellular carcinoma by decreasing the stability of Nrdp1, which results in up-regulation of ErbB3 (show ERBB3 Proteins)
the association between RNF41 polymorphisms and congenital heart disease in the Chinese Mongolian population
Nrdp1S is a tumour suppressor that which potentiates the Nrdp1-mediated ubiquitination and degradation of ErbB3 (show ERBB3 Proteins). An Nrdp1S deficiency may also be an important factor in the loss of Nrdp1.
HPV 16 E2 can modulate ErbB-3 (show ERBB3 Proteins) by interacting with Nrdp-1, which is involved in the regulation of this receptor, via ubiquitination and degradation.
The results of this study suggested that Nrdp1-mediated ErbB3 (show ERBB3 Proteins) degradation suppresses glioma migration and invasion and that loss of Nrdp1 may amplify ErbB3 (show ERBB3 Proteins) signaling to contribute to glioma migration and invasion.
Data suggest that ring finger protein 41 Nrdp1 terminates T cell antigen receptors (TCRs) signaling by inactivating Zap70 (show ZAP70 Proteins) kinase.
The novel Pdx1 (show PDX1 Proteins)-Clec16a-Nrdp1 pathway this study describes provides a genetic basis for the pathogenesis of mitochondrial dysfunction in multiple forms of diabetes.
demonstrate that Nrdp1-mediated ubiquitination and activation of C/EBPbeta (show CEBPB Proteins) contributes to a ubiquitin-dependent nonproteolytic pathway that up-regulates Arg1 (show ARG1 Proteins) expression and promotes M2 macrophage polarization
Nrdp1 may be a key mediator in the development of cardiac dysfunction after DOX treatment and associated with inhibition of Akt (show AKT1 Proteins), ERK1/2 and STAT3 (show STAT3 Proteins).
these results provide evidence for an important role for Nrdp1 in regulating ischemia/reperfusioninduced cardiac injury
Post-transcriptional mechanisms contribute to the suppression of the ErbB3 (show ERBB3 Proteins) negative regulator protein Nrdp1 in mammary tumors.
Rnf41 is nominated as a candidate gene for anxiety-like behaviors, depression, and vulnerability to seizures.
Data suggest that Nrdp1 functions as both an adaptor protein and an E3 unbiquitin ligase to regulate TLR responses in different ways.
Nrdp1 is associated with differentiation process of the melanocyte lineage by regulating Erbb3b, an Erbb (show EGFR Proteins) signaling molecule along zebrafish embryogenesis.
This gene encodes an E3 ubiquitin ligase. The encoded protein plays a role in type 1 cytokine receptor signaling by controlling the balance between JAK2-associated cytokine receptor degradation and ectodomain shedding. Alternative splicing results in multiple transcript variants.
E3 ubiquitin-protein ligase NRDP1
, fetal liver ring finger
, neuregulin receptor degradation protein-1