Roundabout, Axon Guidance Receptor, Homolog 4 (Drosophila) (ROBO4) ELISA Kits

Human Roundabout, Axon Guidance Receptor, Homolog 4 (Drosophila) (ROBO4) interaction partners

1. Low expression level of ROBO4 is associated with evasive resistance and disease progression in cancer.

2. GM-CSF (show CSF2 ELISA Kits) and IL-1beta (show IL1B ELISA Kits). Taken together, we demonstrated novel Robo4 functions in inflammation, i.e., it promotes IL-6 (show IL6 ELISA Kits) production by endothelial cells and immune cells via crosstalk.

3. Results show that hyperglycemia-induced upregulation of Robo4 in retinal endothelial cells is directly mediated by transcription factor SP1 (show SP1 ELISA Kits) which increases the transcription of Robo4 via an additional binding site in Robo4 promoter. SP1 (show PSG1 ELISA Kits)/Robo4 can regulate the migration, monolayer permeability and angiogenesis of retinal endothelial cells under hyperglycemic conditions.

4. there was a increase in Robo4 expression under hyperglycemic conditions, while there was a decrease under hypoxic and combined hypoxic and hyperglycemic conditions, suggesting Robo4 might play different roles in various stages of diabetic retinopathy

5. These results suggest that Slit2/Robo1 binding exerts an effect on cell migration, which is negatively regulated by Robo4, and Robo1 may function by interacting with CdGAP in HUVECs.

6. results indicate that AP-1 (show FOSB ELISA Kits) complexes regulate Robo4 gene expression in endothelial cells

7. BM Robo4 expression can serve as a new biomarker to predict clinical outcomes in AML (show RUNX1 ELISA Kits) patients and Robo4 may serve as a potential therapeutic target in patients with higher Robo4 expression.

8. Robo4 suppressed glioma-induced endothelial cell proliferation, migration and tube formation in vitro by inhibiting VEGR2-mediated activation of PI3K (show PIK3CA ELISA Kits)/AKT (show AKT1 ELISA Kits) and FAK (show PTK2 ELISA Kits) signaling pathways.

9. Increased or decreased expression of Robo4 by stimulation or knockdown of HIF-1alpha (show HIF1A ELISA Kits) suggesting that Robo4 is positively regulated by HIF-1alpha (show HIF1A ELISA Kits) under normoxic and hypoxic conditions in microvascular endothelial cells in vitro.

10. Plasma Robo4 levels are increased, transiently, following cardiac surgery requiring CPB (show CPB1 ELISA Kits)

Mouse (Murine) Roundabout, Axon Guidance Receptor, Homolog 4 (Drosophila) (ROBO4) interaction partners

1. Robo4 inhibits angiogenesis and vessel permeability independently of its cytoplasmic domain. Robo4 deletion enhances permeability and revascularization in oxygen-induced retinopathy (OIR) and accelerates cutaneous wound healing.

2. endothelial Robo4 signaling is important for suppressing breast cancer growth and metastasis, and it can be targeted (enhanced) by administrating a small molecular drug.

3. Robo4 vaccines induce antibodies that retard tumor growth.

4. Robo4 and Src family kinases are involved in the mechanisms of embryonic vascular defects caused by the Hrt/Hey deficiency.

5. These results clearly indicate that Robo4 plays a role in hematopoietic stem cells trafficking such as bone marrow homing and peripheral mobilization.

6. our results showed an important role of Robo4 in the regulation of cortical radial migration through Slit-dependent and -independent mechanisms

7. Data found that expression of Slit2 (show SLIT2 ELISA Kits) and SDF1 (show CXCL12 ELISA Kits) were dynamically regulated in mesenchymal stem cells and OBC-like populations following radiation, while Robo4 expression was restricted to endothelial cells.

8. augmenting the host Robo4/Slit2 system could provide a useful therapeutic approach to control pathological angiogenesis associated with HSV induced stromal keratitis

9. Robo4 specifically binds to UNC5B (show UNC5B ELISA Kits), a vascular Netrin receptor, revealing unexpected interactions between two endothelial guidance receptors.

10. Activating with the soluble ligand Slit an endothelium-specific, Robo4-dependent signaling pathway that strengthens the vascular barrier, diminishing deleterious aspects of the host's response to the pathogen-induced cytokine storm.

Zebrafish Roundabout, Axon Guidance Receptor, Homolog 4 (Drosophila) (ROBO4) interaction partners

1. Sox7 (show SOX7 ELISA Kits) and Sox18 (show SOX18 ELISA Kits)-mediated transcriptional regulation of Robo4 is important in the developing embryonic vasculature

2. robo4 is essential for coordinated symmetric and directed sprouting of intersomitic vessels.

3. Robo4 mediates attraction-signaling mechanisms through Rho GTPases in vertebrate vascular guidance