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The protein encoded by SMAD9 is a member of the SMAD family, which transduces signals from TGF-beta family members. Additionally we are shipping SMAD9 Antibodies (81) and SMAD9 Kits (6) and many more products for this protein.
Showing 7 out of 7 products:
Mutations in SMAD9 gene encoding for transforming growth factor (TGF)-[beta] superfamily have been identified in Pulmonary Arterial Hypertension.
Phosphorylated Smad1/5/8/9 specifically bound to the BREs of Smad8/9 gene. The present study reveals that Smad8/9 is a unique R-Smad regulated through the BMP pathway at the mRNA level.
Case Report: hamartomatous olyposis and gastrointestinal ganglioneuromas with SMAD9 germline mutation that reduces PTEN expression.
a detailed computational model for TGF-beta (show TGFB1 Proteins) signalling that incorporates elements of previous models together with crosstalking between Smad1 (show GARS Proteins)/5/8 and Smad2 (show SMAD2 Proteins)/3 channels through a negative feedback loop dependent on Smad7 (show SMAD7 Proteins).
ATP production by NaF (show IL8 Proteins) promotes hypertrophy-like changes via activation of phospho-Smad8
TNF (show TNF Proteins) activated NF-kappaB (show NFKB1 Proteins) pathway and inhibited the phosphorylation of Smad 1 (show GARS Proteins)/5/8 and BMP-2 (show BMP2 Proteins)-induced osteoblastic differentiation in BMMSCs
CREBZF (show CREBZF Proteins), a novel Smad8-binding protein.
Data suggest that Smads 1, 5 and 8 as potential prognostic markers and therapeutic targets for mTOR (show FRAP1 Proteins) inhibition therapy of prostate cancer.
Endoglin (show ENG Proteins) promotes transforming growth factor beta-mediated Smad 1 (show GARS Proteins)/5/8 signaling and inhibits endothelial cell migration through its association with GIPC (show GIPC1 Proteins)
Study described the first mutation in SMAD8 in a patient with IPAH, and suggested the involvement of SMAD8 in the pathogenesis of PAH.
Sphingosine 1 phosphate also up-regulated runt-related transcription factor 2 (Runx2 (show RUNX2 Proteins)) expression through S1PR2 (show S1PR2 Proteins)/RhoA (show RHOA Proteins)/ROCK/Smad1 (show SMAD1 Proteins)/5/8 signaling.
BetA can enhance in vivo osteogenic potentials of BMP2 (show BMP2 Proteins), possibly via stimulating Smad 1 (show SMAD1 Proteins)/5/8 and p38 (show CRK Proteins) pathways, and combination of both agents can be considered as a therapeutic strategy for bone diseases.
findings suggest that Smad9 is a new type of transcriptional regulator in BMP signaling.
The findings demonstrate for the first time that KMUP-1 can promote osteoblast maturation and differentiation in vitro via BMP-2 (show BMP2 Proteins)/Smad1 (show SMAD1 Proteins)/5/8 and Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathways.
Data indicate that PDGF (show PDGFA Proteins)-AA promotes mesenchymal stem cel migration via bone morphogenetic protein 2 (BMP2 (show BMP2 Proteins))-smad (show SMAD1 Proteins) proteins smad1 (show SMAD1 Proteins)/5/8 activation requires lysosome-mediated degradation of PDGF (show PDGFA Proteins) alpha Receptor (PDGFRalpha).
our data suggest a pivotal role for canonical BMP signaling demonstrating distinguished nonoverlapping function of pSmad8 with pSmad1 and pSmad5 in hfSCs regulation and hair morphogenesis but a redundant role in adult hair progenitors differentiation.
Data show that HtrA1 (show HTRA1 Proteins) is produced during osteoclastogenesis, and negatively regulates osteoblast differentiation, osteoblast differentiation and BMP2 (show BMP2 Proteins)-induced Smad1 (show SMAD1 Proteins)/5/8, ERK1/2 and p38 (show CRK Proteins) phosphorylation in pre-osteoblasts.
FGF2 (show FGF2 Proteins) inhibited BMP9 (show GDF2 Proteins)-induced osteogenic differentiation by blocking BMP9 (show GDF2 Proteins)-induced Smads signaling and subsequently reducing Smads dependent up-regulation of ALK1 (show ACVRL1 Proteins) and ALK2 (show ACRV1 Proteins) in mesenchymal stem cells.
a detailed computational model for TGF-beta (show TGFB1 Proteins) signalling that incorporates elements of previous models together with crosstalking between Smad1 (show SMAD1 Proteins)/5/8 and Smad2 (show SMAD2 Proteins)/3 channels through a negative feedback loop dependent on Smad7 (show SMAD7 Proteins).
The protein encoded by this gene is a member of the SMAD family, which transduces signals from TGF-beta family members. The encoded protein is activated by bone morphogenetic proteins and interacts with SMAD4. Two transcript variants encoding different isoforms have been found for this gene.
MAD, mothers against decapentaplegic homolog 9
, Mothers against decapentaplegic-like protein 9
, mothers against decapentaplegic homolog 9
, SMAD family member 9
, mothers against decapentaplegic homolog 9-like
, MAD homolog 9
, Mothers against decapentaplegic, drosophila, homolog of, 9
, SMAD, mothers against DPP homolog 9
, mothers against DPP homolog 9
, SMAD 9
, SMAD, mothers against DPP 8
, TGF-beta signal transducer Smad8