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Members of the SOX family of transcription factors are characterized by the presence of a DNA-binding high mobility group (HMG) domain, homologous to the HMG box of sex-determining region Y (SRY). Additionally we are shipping SOX12 Proteins (5) and SOX12 Kits (2) and many more products for this protein.
Showing 10 out of 55 products:
Human Polyclonal SOX12 Primary Antibody for WB - ABIN520388
Zhang, Thevapriya, Kim, Yu, Je, Tan, Zeng: Amyloid precursor protein regulates neurogenesis by antagonizing miR-574-5p in the developing cerebral cortex. in Nature communications 2014
Dog (Canine) Polyclonal SOX12 Primary Antibody for WB - ABIN2777869
Satoh, Tada, Tachiki, Tsuchiya, Shimoda, Akao, Sato, Habuchi, Suzuki, Kato: Chrono and clinical pharmacokinetic study of tacrolimus in continuous intravenous administration. in International journal of urology : official journal of the Japanese Urological Association 2001
Show all 2 Pubmed References
SOX12 can increase the expression of CDK4 (show CDK4 Antibodies) and IGF2BP1 (show IGF2BP1 Antibodies), which confer malignant phenotypes to HepatocellularCarcinoma.
Data found that, in hepatocellular carcinoma (HCC (show FAM126A Antibodies)) cell lines, Sox12+ HCC (show FAM126A Antibodies) cells generated significantly more tumor spheres in culture, were more chemo-resistant to cisplatin, were detected in circulation more frequently, and formed distal tumor more frequently compared to Sox12- HCC (show FAM126A Antibodies) cells. Moreover, Sox12 appeared to functionally contribute to the stemness of HCC (show FAM126A Antibodies) cells.
SOX12 may be involved in leukemia progression by regulating the expression of beta-catenin (show CTNNB1 Antibodies) and then interfering with TCF (show HNF4A Antibodies)/Wnt (show WNT2 Antibodies) pathway, which may be a target for AML (show RUNX1 Antibodies).
In this study we screened the transcriptional profiles of 70 MCL patients for SOXC cluster and miR17, miR18a, miR19b and miR92a, from the miR-17-92 cluster. Gene expression analysis showed higher SOX11 and SOX12 levels compared to SOX4 (P = 0.0026). Moreover we found a negative correlation between the expression of SOX11 and SOX4
Up-regulated Sox12 induced by FoxQ1 (show FOXQ1 Antibodies) promotes hepatocellular carcinoma invasion and metastasis by transactivating Twist1 (show TWIST1 Antibodies) and FGFBP1 (show FGFBP1 Antibodies) expression.
This genome-wide screen has identified two novel metastatic suppressors: TMED3 (show TMED3 Antibodies) and SOX12, the knockdown of which increases metastatic growth after direct seeding.
SOX12 and NRSN2 (show NRSN2 Antibodies) were identified as candidate genes that may be involved in the developmental defects in 20p13 microdeletion.
SOXC proteins act cell- and non-cell-autonomously in perichondrocytes and chondrocytes to establish noncanonical WNT (show WNT2 Antibodies) signaling crosstalk essential for growth plate induction and control
Study show that the survival of neural and mesenchymal progenitor cells critically relies on the redundantly acting SoxC transcription factors Sox4, Sox11 (show SOX11 Antibodies) and Sox12.
Sox4 and Sox11 (show SOX11 Antibodies) function redundantly with Sox12 and can compensate its loss during mouse development.
Members of the SOX family of transcription factors are characterized by the presence of a DNA-binding high mobility group (HMG) domain, homologous to the HMG box of sex-determining region Y (SRY). Forming a subgroup of the HMG domain superfamily, SOX proteins have been implicated in cell fate decisions in a diverse range of developmental processes. SOX transcription factors have diverse tissue-specific expression patterns during early development and have been proposed to act as target-specific transcription factors and/or as chromatin structure regulatory elements. The protein encoded by this gene was identified as a SOX family member based on conserved domains, and its expression in various tissues suggests a role in both differentiation and maintenance of several cell types.
, SRY-related HMG-box gene 22
, transcription factor SOX-12
, SRY-box containing gene 12
, Transcription factor Sox-33
, transcription factor Sox-12