anti-SRY (Sex Determining Region Y)-Box 17 (SOX17) Antibodies

SOX17 encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. Additionally we are shipping SOX17 Proteins (4) and SOX17 Kits (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SOX17 64321 Q9H6I2
SOX17 312936  
SOX17 20671 Q61473
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Top anti-SOX17 Antibodies at antibodies-online.com

Showing 10 out of 95 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Dog Mouse Un-conjugated IF, IHC, WB Anti-SOX17 mouse monoclonal antibody (ABIN2452377) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SOX17 (RC220888). Immunofluorescent staining of A549 cells using anti-SOX17 mouse monoclonal antibody (ABIN2452377). 0.1 mL 2 to 3 Days
$462.00
Details
Dog Rabbit Un-conjugated IHC, WB WB Suggested Anti-SOX17 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  Hela cell lysate Rabbit Anti-SOX17 Antibody  Paraffin Embedded Tissue: Human Kidney Antibody Concentration: 5 ug/ml 100 μL 2 to 3 Days
$319.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-SOX17 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: Human Lung 100 μL 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated FACS, IF, IHC, WB Anti-SOX17 mouse monoclonal antibody (ABIN2452673) immunofluorescent staining of HeLa cells transiently transfected by pCMV6-ENTRY SOX17 (RC220888) Immunofluorescent staining of HeLa cells using anti-SOX17 mouse monoclonal antibody (ABIN2452673). 0.1 mL 2 to 3 Days
$462.00
Details
Human Goat Un-conjugated ELISA   100 μg 6 to 7 Days
$291.53
Details
Human Mouse Un-conjugated FACS, IF, IHC, IHC (p), WB 100 μL 11 to 14 Days
$522.50
Details
Dog Mouse Un-conjugated IF, WB 100 μL 11 to 14 Days
$522.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of SOX17 expression in HeLa (A), LNCaP (B), DU145 (C) whole cell lysates. 200 μL 13 to 14 Days
$487.50
Details
Dog Mouse Un-conjugated IF, IHC, IHC (p), WB 100 μL 11 to 14 Days
$522.50
Details
Dog Rabbit Un-conjugated IHC, IHC (p), WB Human Kidney (formalin-fixed, paraffin-embedded) stained with SOX17 antibody ABIN462221 followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Human Testis (formalin-fixed, paraffin-embedded) stained with SOX17 antibody ABIN462221 followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 100 μL 11 to 14 Days
$727.83
Details

Top referenced anti-SOX17 Antibodies

  1. Dog (Canine) Monoclonal SOX17 Primary Antibody for IF, IHC - ABIN2732436 : Bode, Barghorn, Fritzsche, Riener, Kristiansen, Knuth, Moch: MAGEC2 is a sensitive and novel marker for seminoma: a tissue microarray analysis of 325 testicular germ cell tumors. in Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2011 (PubMed)
    Show all 10 Pubmed References

  2. Human Polyclonal SOX17 Primary Antibody for FACS - ABIN4895920 : Bernardo, Faial, Gardner, Niakan, Ortmann, Senner, Callery, Trotter, Hemberger, Smith, Bardwell, Moffett, Pedersen: BRACHYURY and CDX2 mediate BMP-induced differentiation of human and mouse pluripotent stem cells into embryonic and extraembryonic lineages. in Cell stem cell 2011 (PubMed)
    Show all 5 Pubmed References

  3. Human Monoclonal SOX17 Primary Antibody for FACS, IF - ABIN2732433 : Takeuchi, Nakatsuji, Suemori: Endodermal differentiation of human pluripotent stem cells to insulin-producing cells in 3D culture. in Scientific reports 2014 (PubMed)
    Show all 4 Pubmed References

  4. Human Polyclonal SOX17 Primary Antibody for ICC, IF - ABIN4355356 : Schröter, Sleegers, Van Cauwenberghe, Bohndorf, Wruck, Van Broeckhoven, Adjaye: Lymphoblast-derived integration-free iPSC lines from a female and male Alzheimer's disease patient expressing different copy numbers of a coding CNV in the Alzheimer risk gene CR1. in Stem cell research 2016 (PubMed)
    Show all 2 Pubmed References

  5. Dog (Canine) Polyclonal SOX17 Primary Antibody for IHC, WB - ABIN2781184 : Zhang, Glöckner, Guo, Machida, Wang, Easwaran, Van Neste, Herman, Schuebel, Watkins, Ahuja, Baylin: Epigenetic inactivation of the canonical Wnt antagonist SRY-box containing gene 17 in colorectal cancer. in Cancer research 2008 (PubMed)
    Show all 2 Pubmed References

  6. Human Polyclonal SOX17 Primary Antibody for ELISA - ABIN451622 : Kim, Saunders, Morrison: Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells. in Cell 2007 (PubMed)

  7. Human Polyclonal SOX17 Primary Antibody for IF, ELISA - ABIN238986 : Holmberg, He, Peredo, Orrego, Hesselager, Ericsson, Hovatta, Oba-Shinjo, Marie, Nistér, Muhr: Activation of neural and pluripotent stem cell signatures correlates with increased malignancy in human glioma. in PLoS ONE 2011 (PubMed)

  8. Human Monoclonal SOX17 Primary Antibody for FACS - ABIN4895919 : Liu, Van Bortle, Zhang, Zhao, Zhang, Geller, Gruber, Jiang, Wu, Snyder: Disruption of mesoderm formation during cardiac differentiation due to developmental exposure to 13-cis-retinoic acid. in Scientific reports 2018 (PubMed)

More Antibodies against SOX17 Interaction Partners

Human SRY (Sex Determining Region Y)-Box 17 (SOX17) interaction partners

  1. Study in a mouse endotoxemia model of inflammatory endothelial injury and human cells demonstrated that endothelial Sox17 expression plays an obligatory role in normalizing the endothelium. Restoration of endothelial integrity is mediated by activation of HIF-1alpha, upregulation of its target Sox17, and subsequent downstream expression of Cyclin E1 which mediates endothelial regeneration.

  2. This study reveals a novel mechanism by which SOX17 transcriptionally inactivates DNA repair and damage response-related genes to sensitize esophageal squamous cell carcinoma cell or xenograft to concurrent chemoradiation therapy treatment.

  3. The Sox17-Notch1-Hes1 pathway is critical for maintaining the undifferentiated state of IAHCs.

  4. Case-control analyses reveal significant overrepresentation of rare variants in ATP13A3, AQP1 and SOX17, and provide independent validation of a critical role for GDF2 in heritable pulmonary arterial hypertension.

  5. These data strongly implicate SOX17 as a new risk gene contributing to Pulmonary arterial hypertension-congenital heart disease.

  6. This study showed that 1 of 4 SNPs located near the SOX17 gene, rs1072737, was statistically associated with intracranial aneurysm (IA) formation in a Korean population. The MAF of this variant (minor allele, C) showed a highly ethnic difference between Korean and European populations. Two SNPs rs10958409 and rs9298506 showed statistically significant associations with increased IA risk in the current meta-analysis.

  7. The combination of methylated SOX17 with cytology better predicted neoplastic grade than cytology alone

  8. SOX17 acts as a tumor suppressor in cholangiocarcinoma and its genetic, molecular and/or pharmacological restoration may represent a new promising therapeutic strategy.

  9. Our results suggest that decreasing SOX17 levels may promote EC development and progression, and that by downregulating MAML3 expression and Wnt signaling, SOX17 acts as a tumor suppressor that may improve outcome in patients with EC.

  10. SOX2 repression in TCam-2 cells can be abrogated by recruitment of the constitutively expressed H3K27 demethylase UTX to the SOX2 promoter through retinoid signaling, leading to expression of neuronal and other lineage genes. SOX17 has been shown to initiate human PGC specification, with its target PRDM1 suppressing mesendodermal genes

  11. Dedifferentiation of fibroblasts to CD34(+) progenitor cells gives rise to endothelial cells and erythroblasts in a SOX17-dependent manner.

  12. Study extracted and analyzed the experimentally validated 3D models of SOX17-HMG domain and beta-catenin; the molecular level disturbance in the two essential human proteins upon M76A and G103R mutation of SOX17, which further hampers the cell signaling phenomena for the human cytological developments beginning from gastrulation and endoderm formation.

  13. SOX17 promoter is highly methylated in primary tumors and in corresponding plasma samples both in operable and advanced non-small cell lung cancer.

  14. The definitive endoderm and foregut endoderm differentiation capabilities of Wnt pathway-modulated cells were determined based on the expression levels of the endodermal transcription factors SOX17 and FOXA2 and those of the transcription activator GATA4 and the alpha-fetoprotein (AFP) gene, respectively.

  15. Knockdown of OCT4 during differentiation inhibits mesendoderm formation and removal of the H3K27me3 mark from the SOX17 promoter, suggesting that OCT4 acts to induce removal of the Polycomb2 complex.

  16. high expression of the Sox17 associated pathway in medium and small arteries indicates that Brain arteriovenous malformation vessels are intrinsically active

  17. SOX17 demethylation induced miR-371-5p expression and consequently suppressed its direct target SOX2. A novel mechanism of the SOX17/miR-371-5p/SOX2 axis is involved in the regulation of EMT, stemness and metastasis.

  18. Decreased expression of SOX17 is associated with tumor progression in breast cancer.

  19. In this study, oligodendroglioma patients with 1p/19q LOH and Sox17 protein expression had a better prognosis.

  20. SOX17 might play a role in the development of Ovarian Cancer, and may be a therapeutic target in OC.

Zebrafish SRY (Sex Determining Region Y)-Box 17 (SOX17) interaction partners

  1. Targeted knockdown of Sox17 and Chd in dorsal forerunner cells led to aberrant Left-Right (L-R) asymmetry establishment, as visualized by the expression of southpaw and lefty, and heart and pancreas placement in the embryo.

  2. knockout of dusp4 revealed a specific loss of sox17, establishing a new class of endoderm specification defect

  3. Results describe sox17 cis-regulatory elements, and examine the specific input predictions of the gene regulatory networks.

Mouse (Murine) SRY (Sex Determining Region Y)-Box 17 (SOX17) interaction partners

  1. Study in a mouse endotoxemia model of inflammatory endothelial injury and human cells demonstrated that endothelial Sox17 expression plays an obligatory role in normalizing the endothelium. Restoration of endothelial integrity is mediated by activation of HIF-1alpha, upregulation of its target Sox17, and subsequent downstream expression of Cyclin E1 which mediates endothelial regeneration.

  2. Data show that SOX7, SOX17 and SOX18 (SOXF) transcriptional factors are induced during satellite cell specification.

  3. During early postnatal development, Sox17 overexpression increases the pool of OPCs at the expense of differentiated oligodendrocytes. However, the oligodendroglial cell population, oligodendrocyte progenitor cells (OPCs)proliferation and apoptosis remained unchanged in Sox17 transgenic mice. Sox17 represses the expression of the major myelin genes, resulting in a severe CNS hypomyelination.

  4. SOX17 regulates uterine epithelial-stromal cross-talk acting via a distal enhancer upstream of Ihh

  5. Enforced expression of Sox17 increases expression of morphogenesis genes and promotes integration of transplanted converted cells into injured vessels.

  6. The defective gallbladder contraction positively correlated with the severity of embryonic hepatitis in Sox17(+/-) embryos, suggesting a potential contribution of embryonic cholecystitis and fetal gallbladder contraction in the early pathogenesis of congenital biliary atresia.

  7. Sox17 disruption in epithelial and stromal compartments led to inhibition of endometrial adenogenesis and a loss of reproductive capacity. Epithelium-specific Sox17 disruption resulted in normal adenogenesis although reproductive capacity remained impaired. Non-epithelial, Sox17-positive cells are necessary for adenogenesis and endometrial glands require Sox17 to properly function.

  8. SOX-17 transcription factor is indispensable in developmental angiogenesis and as a positive feedback regulator of VEGF signaling.

  9. findings indicate the role of Sry-related HMG box gene-17 (Sox17) in uterine receptivity to embryo implantation.

  10. combined deletion of Sox7, Sox17, and Sox18 at the onset of retinal angiogenesis leads to a dense capillary plexus with a nearly complete loss of radial arteries and veins, whereas the presence of a single Sox17 allele largely restores arterial identity

  11. Sox17 inhibition of Runx1 and Gata2 maintains endothelial fate in endothelial-to-haematopoietic transition

  12. Sox17 deficiency in mouse can induce intracranial aneurysm under hypertensive conditions, suggesting Sox17 deficiency as a potential genetic factor for IA formation.

  13. These results identify a novel role for Sox17 in adult liver as a modulator of the metabolic adaptation to fasting.

  14. the transcription factor SOX17, which is activated in prospective definitive endoderm cells before intercalation, is necessary for gut endoderm morphogenesis and the assembly of the basement membrane that separates gut endoderm from mesoderm.

  15. Hhex and Cer1 are indispensable components of the Sox17 pathway for cardiopoiesis.

  16. A regulatory network, incluing Sox17 and the retinoic acid receptor, controls nephrocan expression and midgut patterning.

  17. Sox17 promotes endothelial migration. It destabilizes endothelial junctions, rearranges the cytoskeleton, and upregulates several genes expressed in tip cells. The Notch pathway regulates Sox17 expression mainly at the post-transcriptional level.

  18. SoxF proteins, especially Sox17, contribute to the maintenance of cell clusters containing hematopoietic stem cells in the midgestation aorta-gonad-mesonephros region

  19. Sox17 is a component of the complex signaling network that orchestrates arterial/venous specification.

  20. Sox17 is required for normal formation of the pulmonary vasculature and postnatal cardiovascular homeostasis.

SOX17 Antigen Profile

Protein Summary

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins.

Gene names and symbols associated with SOX17

  • SRY-box 17 (SOX17) antibody
  • SRY (sex determining region Y)-box 17 (sox17) antibody
  • SRY box 17 (Sox17) antibody
  • SRY-box 17 alpha (sox17a) antibody
  • SRY-box 17 (sox17) antibody
  • sox7/17 protein (sox7/17) antibody
  • SRY (sex determining region Y)-box 17 (Sox17) antibody
  • SRY-box 17 (Sox17) antibody
  • Sox antibody
  • sox7/17 antibody
  • sox17 antibody
  • sox17-alpha antibody
  • Sox17alpha antibody
  • tSox17alpha antibody
  • VUR3 antibody
  • Xsox17 antibody
  • Xsox17-alpha antibody
  • xsox17a antibody
  • Xsox17alpha antibody
  • xSox17alpha1 antibody
  • xSox17alpha2 antibody

Protein level used designations for SOX17

SRY-related HMG-box transcription factor SOX17 , transcription factor SOX-17 , SRY-box 17 , SRY-box containing gene 17 , HMG box transcription factor Sox17-alpha , sox17 alpha , transcription factor Sox-17-alpha , HMG transcription factor SOX17 , SRY (sex determining region Y)-box 17 , sox7/17 protein , LOW QUALITY PROTEIN: transcription factor SOX-17

GENE ID SPECIES
64321 Homo sapiens
30544 Danio rerio
312936 Rattus norvegicus
395066 Xenopus (Silurana) tropicalis
428534 Gallus gallus
486955 Canis lupus familiaris
534010 Bos taurus
694097 Macaca mulatta
740572 Pan troglodytes
100304455 Oryzias latipes
100591356 Nomascus leucogenys
100303486 Saccoglossus kowalevskii
20671 Mus musculus
100719584 Cavia porcellus
100154087 Sus scrofa
Selected quality suppliers for anti-SOX17 (SOX17) Antibodies
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