anti-SRY (Sex Determining Region Y)-Box 17 (SOX17) Antibodies

SOX17 encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. Additionally we are shipping SOX17 Proteins (4) and SOX17 Kits (1) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SOX17 64321 Q9H6I2
SOX17 312936  
SOX17 20671 Q61473
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Top anti-SOX17 Antibodies at antibodies-online.com

Showing 10 out of 91 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Dog Rabbit Un-conjugated IHC, WB <b>WB Suggested Anti-SOX17 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>Hela cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-SOX17 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: Human Lung 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of SOX17 expression in HeLa (A), LNCaP (B), DU145 (C) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Mouse Un-conjugated BI, IF, ICS, WB Western blot analysis of Sox17 in definitive endoderm derived from human embryonic stem (ES) cells. H9 human ES cells (WiCell, Madison, WI) were differentiated to definitive endoderm for 3 days (D’Amour et al, 2005) in RPMI medium supplemented with 0.5% FBS, 1× L-glutamine, and 100 ng/ml Activin A (R&D Systems). Lysates from control ES cells (lane 1) and from day 1 (lane 2) and day 3 (lane 3) differentiated cells were probed with Purified Mouse anti-Human Sox17 antibody at 1.0 µg/ml. The presence of Sox17 is demonstrated by the 45-kDa band in human ES-derived definitive endodermal cells (Lane 3), which is absent in H9 human ES cells (Lane 1) and at day 1 of differentiation (Lane 2). Purified Mouse anti-Hsp90 monoclonal antibody (ABIN967957) was used as a gel-loading control (MW 90 kDa). Flow cytometric analysis of Sox17 in definitive endoderm derived from human embryonic stem (ES) cells. H9 human ES cells (WiCell, Madison, WI) grown on an irradiated mouse embryonic feeder layer were differentiated to definitive endoderm for 3 days (D’Amour et al, 2005) in RPMI medium supplemented with 0.5% FBS, 1× L-glutamine, and 100 ng/ml Activin A (R&D Systems). Day-3 differentiated cells were fixed with BD Cytofix buffer and permeabilized with BD™ Phosflow Perm buffer III. The cells were stained with either Purified Mouse IgG1, kappa isotype control (dashed line) or Purified Mouse Anti-human Sox17 antibody (solid line) at matched concentrations. The second-step reagent was APC goat anti-mouse Ig. The histograms were derived from gated events based on light scattering characteristics of the H9-derived endoderm cells. Flow cytometry was performed on a BD LSR™ II flow cytometry system. 0.1 mg Log in to see 6 to 8 Days
$243.52
Details
Human Mouse Un-conjugated FACS, IF, IHC (p), WB 100 μL Log in to see 7 to 9 Days
$507.83
Details
Dog Mouse Un-conjugated IF, WB 100 μL Log in to see 7 to 9 Days
$507.83
Details
Human Goat APC FACS Detection of SOX17 in Definitive Endoderm-differentiated BG01V Human Stem Cells by Flow Cytometry. Definitive endoderm-differentiated. 100 Tests Log in to see 8 to 9 Days
$357.65
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB Western Blot: SOX17 Antibody [NBP2-24568] - Analysis of SOX17 in mouse embryo brain lysate in the 1) absence and 2) presence of immunizing peptide using SOX17 antibody at 1 ug/ml. Goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test. Immunohistochemistry-Paraffin: SOX17 Antibody [NBP2-24568] - Formalin-fixed, paraffin-embedded human uterus (top) and testis (bottom) stained with SOX17 antibody at 10 ug/ml. 0.1 mg Log in to see 7 to 9 Days
$485.88
Details
Dog Mouse Un-conjugated IF, IHC (p), WB 100 μL Log in to see 7 to 9 Days
$522.50
Details
Dog Rabbit Un-conjugated IHC (p), WB Human Kidney (formalin-fixed, paraffin-embedded) stained with SOX17 antibody ABIN462221 followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Human Testis (formalin-fixed, paraffin-embedded) stained with SOX17 antibody ABIN462221 followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 7 to 9 Days
$727.83
Details

SOX17 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Mouse (Murine)
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Top referenced anti-SOX17 Antibodies

  1. Human Monoclonal SOX17 Primary Antibody for BI, IF - ABIN967681 : DAmour, Agulnick, Eliazer, Kelly, Kroon, Baetge: Efficient differentiation of human embryonic stem cells to definitive endoderm. in Nature biotechnology 2005 (PubMed)
    Show all 6 Pubmed References

  2. Human Polyclonal SOX17 Primary Antibody for FACS - ABIN4895920 : Bernardo, Faial, Gardner, Niakan, Ortmann, Senner, Callery, Trotter, Hemberger, Smith, Bardwell, Moffett, Pedersen: BRACHYURY and CDX2 mediate BMP-induced differentiation of human and mouse pluripotent stem cells into embryonic and extraembryonic lineages. in Cell stem cell 2011 (PubMed)
    Show all 4 Pubmed References

  3. Human Polyclonal SOX17 Primary Antibody for ICC, IF - ABIN4355356 : Schröter, Sleegers, Van Cauwenberghe, Bohndorf, Wruck, Van Broeckhoven, Adjaye: Lymphoblast-derived integration-free iPSC lines from a female and male Alzheimer's disease patient expressing different copy numbers of a coding CNV in the Alzheimer risk gene CR1. in Stem cell research 2016 (PubMed)
    Show all 2 Pubmed References

  4. Dog (Canine) Monoclonal SOX17 Primary Antibody for IF, IHC - ABIN2452377 : Bode, Barghorn, Fritzsche, Riener, Kristiansen, Knuth, Moch: MAGEC2 is a sensitive and novel marker for seminoma: a tissue microarray analysis of 325 testicular germ cell tumors. in Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2011 (PubMed)
    Show all 2 Pubmed References

  5. Dog (Canine) Polyclonal SOX17 Primary Antibody for IHC, WB - ABIN2781184 : Zhang, Glöckner, Guo, Machida, Wang, Easwaran, Van Neste, Herman, Schuebel, Watkins, Ahuja, Baylin: Epigenetic inactivation of the canonical Wnt antagonist SRY-box containing gene 17 in colorectal cancer. in Cancer research 2008 (PubMed)
    Show all 2 Pubmed References

  6. Human Polyclonal SOX17 Primary Antibody for ELISA - ABIN451622 : Kim, Saunders, Morrison: Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells. in Cell 2007 (PubMed)

  7. Human Monoclonal SOX17 Primary Antibody for FACS, IF - ABIN2452673 : Takeuchi, Nakatsuji, Suemori: Endodermal differentiation of human pluripotent stem cells to insulin-producing cells in 3D culture. in Scientific reports 2014 (PubMed)

More Antibodies against SOX17 Interaction Partners

Human SRY (Sex Determining Region Y)-Box 17 (SOX17) interaction partners

  1. The combination of methylated SOX17 with cytology better predicted neoplastic grade than cytology alone

  2. SOX17 acts as a tumor suppressor in cholangiocarcinoma and its genetic, molecular and/or pharmacological restoration may represent a new promising therapeutic strategy.

  3. Our results suggest that decreasing SOX17 levels may promote EC development and progression, and that by downregulating MAML3 (show MAML3 Antibodies) expression and Wnt (show WNT2 Antibodies) signaling, SOX17 acts as a tumor suppressor that may improve outcome in patients with EC.

  4. SOX2 (show SOX2 Antibodies) repression in TCam-2 cells can be abrogated by recruitment of the constitutively expressed H3K27 demethylase (show MBD2 Antibodies) UTX (show KDM6A Antibodies) to the SOX2 (show SOX2 Antibodies) promoter through retinoid signaling, leading to expression of neuronal and other lineage genes. SOX17 has been shown to initiate human PGC (show PGC Antibodies) specification, with its target PRDM1 (show PRDM1 Antibodies) suppressing mesendodermal genes

  5. Dedifferentiation of fibroblasts to CD34 (show CD34 Antibodies)(+) progenitor cells gives rise to endothelial cells and erythroblasts in a SOX17-dependent manner.

  6. Study extracted and analyzed the experimentally validated 3D models of SOX17-HMG (show SSRP1 Antibodies) domain and beta-catenin (show CTNNB1 Antibodies); the molecular level disturbance in the two essential human proteins upon M76A and G103R mutation of SOX17, which further hampers the cell signaling phenomena for the human cytological developments beginning from gastrulation and endoderm formation.

  7. SOX17 promoter is highly methylated in primary tumors and in corresponding plasma samples both in operable and advanced non-small cell lung cancer.

  8. The definitive endoderm and foregut endoderm differentiation capabilities of Wnt (show WNT2 Antibodies) pathway-modulated cells were determined based on the expression levels of the endodermal transcription factors SOX17 and FOXA2 (show FOXA2 Antibodies) and those of the transcription activator GATA4 (show GATA4 Antibodies) and the alpha-fetoprotein (AFP (show AFP Antibodies)) gene, respectively.

  9. Knockdown of OCT4 (show POU5F1 Antibodies) during differentiation inhibits mesendoderm formation and removal of the H3K27me3 mark from the SOX17 promoter, suggesting that OCT4 (show POU5F1 Antibodies) acts to induce removal of the Polycomb2 complex.

  10. high expression of the Sox17 associated pathway in medium and small arteries indicates that Brain arteriovenous malformation vessels are intrinsically active

Zebrafish SRY (Sex Determining Region Y)-Box 17 (SOX17) interaction partners

  1. Targeted knockdown of Sox17 and Chd (show CHRD Antibodies) in dorsal forerunner cells led to aberrant Left-Right (L-R) asymmetry establishment, as visualized by the expression of southpaw and lefty (show LEFTY2 Antibodies), and heart and pancreas placement in the embryo.

  2. knockout of dusp4 (show DUSP4 Antibodies) revealed a specific loss of sox17, establishing a new class of endoderm specification defect

  3. Results describe sox17 cis (show CISH Antibodies)-regulatory elements, and examine the specific input predictions of the gene regulatory networks.

Mouse (Murine) SRY (Sex Determining Region Y)-Box 17 (SOX17) interaction partners

  1. The defective gallbladder contraction positively correlated with the severity of embryonic hepatitis in Sox17(+/-) embryos, suggesting a potential contribution of embryonic cholecystitis and fetal gallbladder contraction in the early pathogenesis of congenital biliary atresia.

  2. Sox17 disruption in epithelial and stromal compartments led to inhibition of endometrial adenogenesis and a loss of reproductive capacity. Epithelium-specific Sox17 disruption resulted in normal adenogenesis although reproductive capacity remained impaired. Non-epithelial, Sox17-positive cells are necessary for adenogenesis and endometrial glands require Sox17 to properly function.

  3. SOX-17 transcription factor is indispensable in developmental angiogenesis and as a positive feedback regulator of VEGF (show VEGFA Antibodies) signaling.

  4. findings indicate the role of Sry (show SRY Antibodies)-related HMG (show SSRP1 Antibodies) box gene-17 (Sox17) in uterine receptivity to embryo implantation.

  5. combined deletion of Sox7 (show SOX7 Antibodies), Sox17, and Sox18 (show SOX18 Antibodies) at the onset of retinal angiogenesis leads to a dense capillary plexus with a nearly complete loss of radial arteries and veins, whereas the presence of a single Sox17 allele largely restores arterial identity

  6. Sox17 inhibition of Runx1 (show RUNX1 Antibodies) and Gata2 (show GATA2 Antibodies) maintains endothelial fate in endothelial-to-haematopoietic transition

  7. Sox17 deficiency in mouse can induce intracranial aneurysm under hypertensive conditions, suggesting Sox17 deficiency as a potential genetic factor for IA formation.

  8. These results identify a novel role for Sox17 in adult liver as a modulator of the metabolic adaptation to fasting.

  9. the transcription factor SOX17, which is activated in prospective definitive endoderm cells before intercalation, is necessary for gut (show GUSB Antibodies) endoderm morphogenesis and the assembly of the basement membrane that separates gut (show GUSB Antibodies) endoderm from mesoderm.

  10. Hhex (show HHEX Antibodies) and Cer1 (show CER1 Antibodies) are indispensable components of the Sox17 pathway for cardiopoiesis.

SOX17 Antigen Profile

Protein Summary

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins.

Gene names and symbols associated with SOX17

  • SRY-box 17 (SOX17) antibody
  • SRY (sex determining region Y)-box 17 (sox17) antibody
  • SRY box 17 (Sox17) antibody
  • SRY-box 17 alpha (sox17a) antibody
  • SRY (sex determining region Y)-box 17 beta, gene 2 (sox17b.2) antibody
  • SRY-box 17 (sox17) antibody
  • sox7/17 protein (sox7/17) antibody
  • SRY (sex determining region Y)-box 17 (Sox17) antibody
  • SRY-box 17 (Sox17) antibody
  • Sox antibody
  • sox7/17 antibody
  • sox17 antibody
  • sox17-alpha antibody
  • Sox17alpha antibody
  • tSox17alpha antibody
  • tSox17beta antibody
  • VUR3 antibody
  • Xsox17 antibody
  • Xsox17-alpha antibody
  • xsox17a antibody
  • Xsox17alpha antibody
  • xSox17alpha1 antibody
  • xSox17alpha2 antibody

Protein level used designations for SOX17

SRY-related HMG-box transcription factor SOX17 , transcription factor SOX-17 , SRY-box 17 , SRY-box containing gene 17 , HMG box transcription factor Sox17-alpha , sox17 alpha , transcription factor Sox-17-alpha , HMG transcription factor SOX17 , SRY (sex determining region Y)-box 17 , SRY (sex determining region Y)-box 17 beta, gene 2 , Transcription factor Sox-17-beta.2 , SRY (sex determining region Y)-box 17-beta.2 , sox7/17 protein , LOW QUALITY PROTEIN: transcription factor SOX-17

GENE ID SPECIES
64321 Homo sapiens
30544 Danio rerio
312936 Rattus norvegicus
395066 Xenopus (Silurana) tropicalis
428534 Gallus gallus
486955 Canis lupus familiaris
534010 Bos taurus
694097 Macaca mulatta
740572 Pan troglodytes
100038235 Xenopus (Silurana) tropicalis
100304455 Oryzias latipes
100591356 Nomascus leucogenys
100303486 Saccoglossus kowalevskii
20671 Mus musculus
100719584 Cavia porcellus
100154087 Sus scrofa
Selected quality suppliers for anti-SOX17 (SOX17) Antibodies
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