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SOX17 encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate.
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Human Polyclonal SOX17 Primary Antibody for FACS - ABIN4895920
Bernardo, Faial, Gardner, Niakan, Ortmann, Senner, Callery, Trotter, Hemberger, Smith, Bardwell, Moffett, Pedersen: BRACHYURY and CDX2 mediate BMP-induced differentiation of human and mouse pluripotent stem cells into embryonic and extraembryonic lineages. in Cell stem cell 2011
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Human Polyclonal SOX17 Primary Antibody for ICC, IF - ABIN4355356
Schröter, Sleegers, Van Cauwenberghe, Bohndorf, Wruck, Van Broeckhoven, Adjaye: Lymphoblast-derived integration-free iPSC lines from a female and male Alzheimer's disease patient expressing different copy numbers of a coding CNV in the Alzheimer risk gene CR1. in Stem cell research 2016
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Dog (Canine) Monoclonal SOX17 Primary Antibody for IF, IHC - ABIN2732436
Bode, Barghorn, Fritzsche, Riener, Kristiansen, Knuth, Moch: MAGEC2 is a sensitive and novel marker for seminoma: a tissue microarray analysis of 325 testicular germ cell tumors. in Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2011
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Dog (Canine) Polyclonal SOX17 Primary Antibody for IHC, WB - ABIN2781184
Zhang, Glöckner, Guo, Machida, Wang, Easwaran, Van Neste, Herman, Schuebel, Watkins, Ahuja, Baylin: Epigenetic inactivation of the canonical Wnt antagonist SRY-box containing gene 17 in colorectal cancer. in Cancer research 2008
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Human Polyclonal SOX17 Primary Antibody for ELISA - ABIN451622
Kim, Saunders, Morrison: Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells. in Cell 2007
Human Monoclonal SOX17 Primary Antibody for FACS, IF - ABIN2732433
Takeuchi, Nakatsuji, Suemori: Endodermal differentiation of human pluripotent stem cells to insulin-producing cells in 3D culture. in Scientific reports 2014
This study showed that 1 of 4 SNPs located near the SOX17 gene, rs1072737, was statistically associated with intracranial aneurysm (IA) formation in a Korean population. The MAF (show MAF Antibodies) of this variant (minor allele, C) showed a highly ethnic difference between Korean and European populations. Two SNPs rs10958409 and rs9298506 showed statistically significant associations with increased IA risk in the current meta-analysis.
The combination of methylated SOX17 with cytology better predicted neoplastic grade than cytology alone
SOX17 acts as a tumor suppressor in cholangiocarcinoma and its genetic, molecular and/or pharmacological restoration may represent a new promising therapeutic strategy.
Our results suggest that decreasing SOX17 levels may promote EC development and progression, and that by downregulating MAML3 (show MAML3 Antibodies) expression and Wnt (show WNT2 Antibodies) signaling, SOX17 acts as a tumor suppressor that may improve outcome in patients with EC.
SOX2 (show SOX2 Antibodies) repression in TCam-2 cells can be abrogated by recruitment of the constitutively expressed H3K27 demethylase (show MBD2 Antibodies) UTX (show KDM6A Antibodies) to the SOX2 (show SOX2 Antibodies) promoter through retinoid signaling, leading to expression of neuronal and other lineage genes. SOX17 has been shown to initiate human PGC (show PGC Antibodies) specification, with its target PRDM1 (show PRDM1 Antibodies) suppressing mesendodermal genes
Dedifferentiation of fibroblasts to CD34 (show CD34 Antibodies)(+) progenitor cells gives rise to endothelial cells and erythroblasts in a SOX17-dependent manner.
Study extracted and analyzed the experimentally validated 3D models of SOX17-HMG (show SSRP1 Antibodies) domain and beta-catenin (show CTNNB1 Antibodies); the molecular level disturbance in the two essential human proteins upon M76A and G103R mutation of SOX17, which further hampers the cell signaling phenomena for the human cytological developments beginning from gastrulation and endoderm formation.
SOX17 promoter is highly methylated in primary tumors and in corresponding plasma samples both in operable and advanced non-small cell lung cancer.
The definitive endoderm and foregut endoderm differentiation capabilities of Wnt (show WNT2 Antibodies) pathway-modulated cells were determined based on the expression levels of the endodermal transcription factors SOX17 and FOXA2 (show FOXA2 Antibodies) and those of the transcription activator GATA4 (show GATA4 Antibodies) and the alpha-fetoprotein (AFP (show AFP Antibodies)) gene, respectively.
Knockdown of OCT4 (show POU5F1 Antibodies) during differentiation inhibits mesendoderm formation and removal of the H3K27me3 mark from the SOX17 promoter, suggesting that OCT4 (show POU5F1 Antibodies) acts to induce removal of the Polycomb2 complex.
Targeted knockdown of Sox17 and Chd (show CHRD Antibodies) in dorsal forerunner cells led to aberrant Left-Right (L-R) asymmetry establishment, as visualized by the expression of southpaw and lefty (show LEFTY2 Antibodies), and heart and pancreas placement in the embryo.
knockout of dusp4 (show DUSP4 Antibodies) revealed a specific loss of sox17, establishing a new class of endoderm specification defect
Results describe sox17 cis (show CISH Antibodies)-regulatory elements, and examine the specific input predictions of the gene regulatory networks.
The defective gallbladder contraction positively correlated with the severity of embryonic hepatitis in Sox17(+/-) embryos, suggesting a potential contribution of embryonic cholecystitis and fetal gallbladder contraction in the early pathogenesis of congenital biliary atresia.
Sox17 disruption in epithelial and stromal compartments led to inhibition of endometrial adenogenesis and a loss of reproductive capacity. Epithelium-specific Sox17 disruption resulted in normal adenogenesis although reproductive capacity remained impaired. Non-epithelial, Sox17-positive cells are necessary for adenogenesis and endometrial glands require Sox17 to properly function.
SOX-17 transcription factor is indispensable in developmental angiogenesis and as a positive feedback regulator of VEGF (show VEGFA Antibodies) signaling.
findings indicate the role of Sry (show SRY Antibodies)-related HMG (show SSRP1 Antibodies) box gene-17 (Sox17) in uterine receptivity to embryo implantation.
combined deletion of Sox7 (show SOX7 Antibodies), Sox17, and Sox18 (show SOX18 Antibodies) at the onset of retinal angiogenesis leads to a dense capillary plexus with a nearly complete loss of radial arteries and veins, whereas the presence of a single Sox17 allele largely restores arterial identity
Sox17 inhibition of Runx1 (show RUNX1 Antibodies) and Gata2 (show GATA2 Antibodies) maintains endothelial fate in endothelial-to-haematopoietic transition
Sox17 deficiency in mouse can induce intracranial aneurysm under hypertensive conditions, suggesting Sox17 deficiency as a potential genetic factor for IA formation.
These results identify a novel role for Sox17 in adult liver as a modulator of the metabolic adaptation to fasting.
the transcription factor SOX17, which is activated in prospective definitive endoderm cells before intercalation, is necessary for gut (show GUSB Antibodies) endoderm morphogenesis and the assembly of the basement membrane that separates gut (show GUSB Antibodies) endoderm from mesoderm.
Hhex (show HHEX Antibodies) and Cer1 (show CER1 Antibodies) are indispensable components of the Sox17 pathway for cardiopoiesis.
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins.
SRY-related HMG-box transcription factor SOX17
, transcription factor SOX-17
, SRY-box 17
, SRY-box containing gene 17
, HMG box transcription factor Sox17-alpha
, sox17 alpha
, transcription factor Sox-17-alpha
, HMG transcription factor SOX17
, SRY (sex determining region Y)-box 17
, sox7/17 protein
, LOW QUALITY PROTEIN: transcription factor SOX-17