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The protein encoded by SLURP1 is a member of the Ly6/uPAR family but lacks a GPI-anchoring signal sequence. Additionally we are shipping SLURP1 Antibodies (42) and SLURP1 Kits (9) and many more products for this protein.
Showing 6 out of 8 products:
Human SLURP1 Protein expressed in Wheat germ - ABIN1320581
Fujii, Horiguchi, Sunaga, Moriwaki, Misawa, Kasahara, Tsuji, Kawashima: SLURP-1, an endogenous ?7 nicotinic acetylcholine receptor allosteric ligand, is expressed in CD205(+) dendritic cells in human tonsils and potentiates lymphocytic cholinergic activity. in Journal of neuroimmunology 2014
These findings strongly suggest that down regulation of SLURP1 expression may be implicated in the pathogenesis of various solid tumors, particularly malignancies of squamous lineage, and thus this gene may be a squamous lineage-specific tumor suppressor.
This is the first mal de Meleda case of Javanese ethnicity to be documented, and the unique mutation has not previously been reported.
We identified a mutation in SLURP1 in five members of a consanguineous family in Pakistan, who had Mal de Meleda.
novel splice site mutation c.58+5G>T in mal de Meleda in India
Results of this study suggest understand Mal de Meleda, it will be important to identify proteins that interact with mutatated SLURP1. In any such studies, it will be important to assess binding of mutant SLURP1 proteins that cause Mal de Meleda.
To our knowledge, the present study is the fi rst report on molecular investigation of Mal de Meleda from Libya.
This supports the hypothesis that the antiproliferative activity of SLURP-1 is related to 'metabotropic' signaling pathway through alpha7-nAChR (show CHRNA7 Proteins), that activates intracellular signaling cascades without opening the receptor channel.
SLURP1 participates in pathophysiology of psoriasis by regulating keratinocyte proliferation and differentiation, and by suppressing the growth of S. aureus
Palmoplantar keratoderma of the Gamborg-Nielsen type is caused by mutations in the SLURP1 gene and represents a variant of Mal de Meleda.
rSLURP-1 decreased production of TNFalpha (show TNF Proteins) by T-cells, downregulated IL-1 beta (show IL1B Proteins) and IL-6 (show IL6 Proteins) secretion by macrophages, and moderately upregulated IL-10 (show IL10 Proteins) production by both types of immunocytes
The hypomorphic Egfr (show EGFR Proteins) allele, which leads to reduced EGFR (show EGFR Proteins) signalling in keratinocytes, did not ameliorate the PPK (show GJB2 Proteins) elicited by SLURP1 deficiency, suggesting that SLURP1 deficiency causes PPK (show GJB2 Proteins) independently (or downstream) from the EGFR (show EGFR Proteins) pathway.
SLURP1 nonsense mutation is responsible for the pathogenesis of palmoplantar keratoderma.
These data describe the influence of age, sex, genetic background, and ocular surface health on mouse corneal expression of Slurp1, establish the baseline for human tear SLURP1 expression.
Slurp1 in mice has a role in neuromuscular and metabolic phenotypes in addition to its role in palmoplantar keratoderma
Those findings suggest that diminished expression of SLURP-1 in asthma attenuates its negative regulation of airway inflammation, and that perhaps changes in SLURP-1 expression could serve as a marker of airway damage in asthma.
The protein encoded by this gene is a member of the Ly6/uPAR family but lacks a GPI-anchoring signal sequence. It is thought that this secreted protein contains antitumor activity. Mutations in this gene have been associated with Mal de Meleda, a rare autosomal recessive skin disorder. This gene maps to the same chromosomal region as several members of the Ly6/uPAR family of glycoprotein receptors.
secreted Ly-6/uPAR-related protein 1
, secreted LY6/PLAUR domain containing 1
, ARS component B
, ARS(component B)-81/S
, anti-neoplastic urinary protein
, lymphocyte antigen 6-like secreted
, secreted Ly6/uPAR related protein 1
, Ars component B
, secreted Ly-6/uPAR related protein 1