Septin 7 Proteins (SEPT7)

SEPT7 encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae.

list all proteins Gene Name GeneID UniProt
Human SEPT7 SEPT7 989 Q16181
Mouse SEPT7 SEPT7 235072 O55131
Rat SEPT7 SEPT7 64551 Q9WVC0
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Top Septin 7 Proteins at

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
Escherichia coli (E. coli) Human His-SUMO Tag   100 μg Log in to see 11 Days
Yeast Human His tag   100 μg Log in to see 8 to 11 Days
Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days

More Proteins for Septin 7 (SEPT7) Interaction Partners

Xenopus laevis Septin 7 (SEPT7) interaction partners

  1. study identified control of septin (show SEPT6 Proteins) localization by the planar cell polarity (PCP (show PRCP Proteins)) protein Fritz (show WDPCP Proteins) as a crucial control point for both collective cell movement and ciliogenesis in embryos

Human Septin 7 (SEPT7) interaction partners

  1. Study discloses both SEPT2 (show SEPT2 Proteins) and SEPT7 are essential for breast cancer cell migration and invasion by controlling MEK (show MAP2K1 Proteins)/ERK (show EPHB2 Proteins) MAPKs activation.

  2. SUMOylation of human septins is critical for septin (show SEPT6 Proteins) filament bundling and cytokinesis.

  3. Low SEPT7 expression is associated with glioma cell invasion.

  4. Results show that SEPT7 is involved in glioma cell migration with the assistance of cofilin (show CFL1 Proteins) phosphomediated cytoskeleton locomotion.

  5. Septin6 and Septin7 GTP binding proteins regulate AP-3- and ESCRT-dependent multivesicular body biogenesis

  6. Significantly lower SEPT7 expression in encapsulated follicular variant of papillary thyroid carcinoma may be a sign of different molecular signature in this type of tissue.

  7. In response to Candida albicans infection, SEPT7 forms a complex with endothelial cell N-cadherin (show CDH2 Proteins), is required for normal accumulation of N-cadherin (show CDH2 Proteins) around hyphae, and is necessary for maximal fungal endocytosis.

  8. SEPT2 (show SEPT2 Proteins) forms a 1:1:1 complex with SEPT7 and SEPT9 (show SEPT9 Proteins).

  9. Overexpression of the yeast septin7 ortholog CDC10 also conferred resistance to the negative effects of copper as well as protecting cells from the overexpression of Bax (show BAX Proteins).

  10. miR (show MLXIP Proteins)-30a-5p is a bona fide negative regulator of SEPT7 and the oncogenic activity of miR (show MLXIP Proteins)-30a-5p in human gliomas is at least in part through the repression of SEPT7

Horse (Equine) Septin 7 (SEPT7) interaction partners

  1. These findings point to a possible pathogenetic role of septin 7 in Equine recurrent uveitis.

Cow (Bovine) Septin 7 (SEPT7) interaction partners

  1. a SNP in the CDC10 gene was associated with growth-related traits in Japanese Black beef cattle

Mouse (Murine) Septin 7 (SEPT7) interaction partners

  1. SEPT7 regulates gross morphogenesis of the inner ear and maintains the size of the inner ear sensory epithelial area. It does not affect differentiation of hair cells and supporting cells. It exerts its effects at an early developmental stage of the inner ear.

  2. Sept7-deficient T cells failed to complete cytokinesis when prompted by pharmacological activation or cytokines. In contrast, cell division was not dependent on sept7 when cell-cell contacts, such as those with antigen-presenting cells, provided a niche.

  3. We identified stathmin (show STMN1 Proteins) as a key molecule aiding in septin (show SEPT6 Proteins)-independent cytokinesis, demonstrated that stathmin (show STMN1 Proteins) supplementation is sufficient to override cytokinesis failure in SEPT7-null fibroblasts

  4. Sept7 provides a physical scaffold for HDAC6 (show HDAC6 Proteins) to achieve efficient microtubule deacetylation, thereby negatively regulating microtubule stability to an optimal level for neuritogenesis.

  5. Septin 7 may regulate meiotic cell cycle progression by affecting microtubule cytoskeletal dynamics in mouse oocytes.

  6. Report SEPT4 (show SEPT4 Proteins)/5/7 expression in mouse cochlea and roles in auditory function.

  7. performed large-scale interaction screens to understand the neuronal functions of the ERK3 (show RYK Proteins)/MK5 (show MAPKAPK5 Proteins) pathway and identified septin7 (Sept7) as a novel interacting partner of ERK3 (show RYK Proteins)

  8. In Sept9 (show SEPT9 Proteins) knockout cells, long septin (show SEPT6 Proteins) filaments stained for Sept7 disappeared. Instead, staining was found in short, often curved filaments and rings. Furthermore, Sept7 was no longer localized to the mitotic spindle

  9. SEPT7 is involved in the regulation of subcellular-compartment formation during spermiogenesis in the mouse.

Septin 7 (SEPT7) Protein Profile

Protein Summary

This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in gliomagenesis and in the suppression of glioma cell growth, and it is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19.

Gene names and symbols associated with Septin 7 Proteins (SEPT7)

  • septin 7a (sept7a)
  • septin 7 (SEPT7)
  • septin 7 L homeolog (sept7.L)
  • septin 7 (sept7)
  • septin 7 (Sept7)
  • CDC3 protein
  • Cdc10 protein
  • E430034N22 protein
  • NBLA02942 protein
  • SEPT7A protein
  • Septin-7 protein
  • wu:fb38h06 protein
  • zgc:56383 protein

Protein level used designations for Septin 7 Proteins (SEPT7)

sept7 , septin 7 , septin-7 , cell division cycle 10 , CDC10 protein homolog , CDC10 cell division cycle 10-like , septin-7-like , CDC10 (cell division cycle 10, S. cerevisiae, homolog) , cell division cycle 10 homolog , CDC10 (cell division cycle 10, S.cerevisiae, homolog)

394136 Danio rerio
420741 Gallus gallus
444612 Xenopus laevis
463349 Pan troglodytes
677666 Macaca mulatta
100022006 Monodelphis domestica
100173884 Pongo abelii
100216295 Xenopus (Silurana) tropicalis
100350569 Oryctolagus cuniculus
100385961 Callithrix jacchus
100599254 Nomascus leucogenys
989 Homo sapiens
475284 Canis lupus familiaris
100070492 Equus caballus
408000 Bos taurus
235072 Mus musculus
64551 Rattus norvegicus
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