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SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Additionally we are shipping SIGLEC10 Antibodies (97) and SIGLEC10 Proteins (8) and many more products for this protein.
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soluble CD52 exerts a concerted immunosuppressive effect by first sequestering HMGB1 to nullify its proinflammatory Box B, followed by binding to the inhibitory Siglec-10 receptor, triggering recruitment of SHP1 to the intracellular immunoreceptor tyrosine-based inhibitory motif of Siglec-10 and its interaction with the TCR.
Siglec-10 is associated with decreased survival and impaired NK cell function in human hepatocellular carcinoma (HCC).
Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium
the apparent occurrence of an unusual TG 3' splice site in intron 11 is discussed
Siglec-10 was demonstrated to be involved in the endocytosis of porcine reproductive and respiratory syndrome virus, confirming the important role of Siglec-10 in virus the entry process.
SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).
sialic acid binding Ig-like lectin 10 Ig-like lectin 7
, sialic acid-binding Ig-like lectin 10
, siglec-like gene 2
, siglec-like protein 2
, sialic acid binding Ig-like lectin G
, sialic acid binding Ig-like lectin 10
, sialic acid-binding Ig-like lectin 10-like