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The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. Additionally we are shipping SSH3 Antibodies (66) and SSH3 Proteins (6) and many more products for this protein.
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Expression of phosphatase-dead versions of SSH proteins, SSH1, SSH2 & SSH3 results in phosphorylation/inactivation of cofilin, changes in cytoskeleton organization, loss of cell polarity, and assembly of aberrant arrays of laminin-332 in keratinocytes.
Dephosphorylates actin-depolymerizing factor/cofilin, but is not essential for viability, fertility, or development of epithelial tissues.
Results suggest that elevation of actin dynamics by Xenopus ADF/cofilin (XAC) activation through Slingshot phosphatase (XSSH) phosphorylation is required for meiotic spindle assembly.
XSSH may reorganize actin filaments through dephosphorylation and reactivation of ADF/cofilin at early stage of contractile ring formation.
Bmp7 gradients steer nerve growth cones by a balancing act of limk1 and SSH on AD/cofilin.
The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1\; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002
, SSH-like protein 3
, protein phosphatase Slingshot homolog 3
, slingshot 3
, slingshot homolog 3
, slingshot-like 3
, slingshot homolog 3 (Drosophila)
, protein phosphatase Slingshot homolog 3-like
, protein phosphatase Slingshot homolog
, slingshot-related protein