Small Proline Rich Protein 2A Proteins (SPRR2A)

Human Small Proline Rich Protein 2A (SPRR2A) interaction partners

1. Expression of SPRR1 (show SPRR1B Proteins) and of SPRR2A is increased in mucosal samples from patients with chronic rhinosinusitis and appeared as a downstream result of TNF alpha (show TNF Proteins) modulation, which possibly resulted in epithelial barrier dysfunction.

2. SPRR2a modulates ZEB-1 signaling by way of miR (show MLXIP Proteins)-200c/141-associated epithelial mesenchyme transition through SH3-domain (show ITSN1 Proteins) networks and contributes to benign and malignant wound-healing responses.

3. SPRR2A-associated tumor behavior was mimicked by MUC1 (show MUC1 Proteins) shRNA, which induced EMT (show ITK Proteins) and, like SPRR2A+ cells, showed reduced metastatic capabilities

4. SPRR2A functions as a suppressor of p53 (show TP53 Proteins)-dependent transcriptional activity, which otherwise might impede cellular processes needed for epithelial wound repair responses.

5. Association of psoriasis to PGLYRP (show PGLYRP1 Proteins) and SPRR (show SPRR1A Proteins) genes at PSORS4 locus on 1q shows heterogeneity between Finnish, Swedish and Irish families.

6. Small proline-rich proteins (SPRR2A) function as SH3 domain (show ITSN1 Proteins) ligands, increase resistance to injury and are associated with epithelial-mesenchymal transition (EMT (show ITK Proteins)) in cholangiocytes.

Mouse (Murine) Small Proline Rich Protein 2A (SPRR2A) interaction partners

1. Sprr2a is selectively expressed in the upper layer of the epithelium surrounding taste buds in the circumvallate papilla

2. Immunohistochemical staining revealed that Sprr2a protein is detected only in the adult uterus, and not in the ovary, oviduct or testis.

3. In non-lesional HPV8-CER (show CBLN1 Proteins) transgenic skin StefinA and Sprr2 are indirect/direct transcriptional targets of HPV8

4. Data show that SPRR2a and b are allergen- and IL-13 (show IL13 Proteins)-induced in experimental allergic responses that may be involved in disease pathophysiology.

5. Small proline-rich proteins (SPRR2A) function as SH3 domain (show ITSN1 Proteins) ligands, increase resistance to injury and are associated with epithelial-mesenchymal transition (EMT (show ITK Proteins)) in cholangiocytes.