anti-Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A) Antibodies

Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. Additionally we are shipping SCNN1A Kits (12) and SCNN1A Proteins (9) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SCNN1A 25122 P37089
SCNN1A 6337 P37088
SCNN1A 20276 Q61180
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Top anti-SCNN1A Antibodies at antibodies-online.com

Showing 10 out of 243 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Mouse Rabbit Un-conjugated ICC, IF, IHC, WB ENaC alpha, rat kidney tissue. 100 μg Log in to see 2 to 3 Days
$394.90
Details
Hamster Rabbit Un-conjugated ICC, IF, IHC, WB Immunohistochemistry analysis using Rabbit Anti-ENaC Polyclonal Antibody . Tissue: kidney tissue. Species: Rat. Primary Antibody: Rabbit Anti-ENaC Polyclonal Antibody  at 1:100. Secondary Antibody: FITC Goat Anti-Rabbit (green). Western blot analysis of Rat kidney tissue lysates showing detection of ENaC protein using Rabbit Anti-ENaC Polyclonal Antibody . Primary Antibody: Rabbit Anti-ENaC Polyclonal Antibody  at 1:1000. 100 μg Log in to see 2 to 3 Days
$394.90
Details
Hamster Rabbit Un-conjugated ICC, IF, IP, IHC, WB ENaC beta, rat kidney tissue. 100 μg Log in to see 2 to 3 Days
$394.90
Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB Western blot analysis of SCNN1A Antibody (Center) (ABIN652752) in WiDr cell line lysates (35 µg/lane). SCNN1A (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human lung carcinoma reacted with SCNN1A Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$335.50
Details
Mouse Rabbit HRP ICC, IF, IHC, WB Western blot analysis of Rat kidney tissue lysates showing detection of ENaC protein using Rabbit Anti-ENaC Polyclonal Antibody . Primary Antibody: Rabbit Anti-ENaC Polyclonal Antibody  at 1:1000. Western blot analysis of Mouse kidney tissue lysates showing detection of ENaC protein using Rabbit Anti-ENaC Polyclonal Antibody . Primary Antibody: Rabbit Anti-ENaC Polyclonal Antibody  at 1:1000. 100 μg Log in to see 2 to 3 Days
$433.40
Details
Mouse Rabbit FITC ICC, IF, IHC, WB Western blot analysis of Rat kidney tissue lysates showing detection of ENaC protein using Rabbit Anti-ENaC Polyclonal Antibody . Primary Antibody: Rabbit Anti-ENaC Polyclonal Antibody  at 1:1000. Western blot analysis of Mouse kidney tissue lysates showing detection of ENaC protein using Rabbit Anti-ENaC Polyclonal Antibody . Primary Antibody: Rabbit Anti-ENaC Polyclonal Antibody  at 1:1000. 100 μg Log in to see 2 to 3 Days
$437.80
Details
Mouse Rabbit Alkaline Phosphatase (AP) ICC, IF, IHC, WB Western blot analysis of Rat kidney tissue lysates showing detection of ENaC protein using Rabbit Anti-ENaC Polyclonal Antibody . Primary Antibody: Rabbit Anti-ENaC Polyclonal Antibody  at 1:1000. Western blot analysis of Mouse kidney tissue lysates showing detection of ENaC protein using Rabbit Anti-ENaC Polyclonal Antibody . Primary Antibody: Rabbit Anti-ENaC Polyclonal Antibody  at 1:1000. 100 μg Log in to see 2 to 3 Days
$440.00
Details
Mouse Rabbit Biotin ICC, IF, IHC, WB Western blot analysis of Rat kidney tissue lysates showing detection of ENaC protein using Rabbit Anti-ENaC Polyclonal Antibody . Primary Antibody: Rabbit Anti-ENaC Polyclonal Antibody  at 1:1000. Western blot analysis of Mouse kidney tissue lysates showing detection of ENaC protein using Rabbit Anti-ENaC Polyclonal Antibody . Primary Antibody: Rabbit Anti-ENaC Polyclonal Antibody  at 1:1000. 100 μg Log in to see 2 to 3 Days
$442.20
Details
Mouse Rabbit PE ICC, IF, IHC, WB Western blot analysis of Rat kidney tissue lysates showing detection of ENaC protein using Rabbit Anti-ENaC Polyclonal Antibody . Primary Antibody: Rabbit Anti-ENaC Polyclonal Antibody  at 1:1000. Western blot analysis of Mouse kidney tissue lysates showing detection of ENaC protein using Rabbit Anti-ENaC Polyclonal Antibody . Primary Antibody: Rabbit Anti-ENaC Polyclonal Antibody  at 1:1000. 100 μg Log in to see 2 to 3 Days
$443.30
Details
Mouse Rabbit Streptavidin ICC, IF, IHC, WB Western blot analysis of Rat kidney tissue lysates showing detection of ENaC protein using Rabbit Anti-ENaC Polyclonal Antibody . Primary Antibody: Rabbit Anti-ENaC Polyclonal Antibody  at 1:1000. Western blot analysis of Mouse kidney tissue lysates showing detection of ENaC protein using Rabbit Anti-ENaC Polyclonal Antibody . Primary Antibody: Rabbit Anti-ENaC Polyclonal Antibody  at 1:1000. 100 μg Log in to see 2 to 3 Days
$444.40
Details

SCNN1A Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-SCNN1A Antibodies

  1. Mouse (Murine) Polyclonal SCNN1A Primary Antibody for ICC, IF - ABIN863202 : Jia, Liu, Sun, Kakizoe, Guan, Zhang, Zhou, Yang: mPGES-1-derived PGE2 mediates dehydration natriuresis. in American journal of physiology. Renal physiology 2013 (PubMed)
    Show all 22 Pubmed References

  2. Hamster Polyclonal SCNN1A Primary Antibody for ICC, IF - ABIN863204 : Gu: Effect of [Cl(-)]i on ENaC activity from mouse cortical collecting duct cells. in Journal of cellular physiology 2008 (PubMed)
    Show all 22 Pubmed References

  3. Hamster Polyclonal SCNN1A Primary Antibody for ICC, IF - ABIN863203 : Dyka, May, Enz: Subunits of the epithelial sodium channel family are differentially expressed in the retina of mice with ocular hypertension. in Journal of neurochemistry 2005 (PubMed)
    Show all 22 Pubmed References

  4. Human Polyclonal SCNN1A Primary Antibody for FACS, ICC - ABIN261466 : Williams, Chamarthi, Goodarzi, Pojoga, Sun, Garza, Raby, Adler, Hopkins, Brown, Jeunemaitre, Ferri, Fang, Leonor, Cui, Guo, Taylor, Ida Chen, Xiang, Raffel, Buchanan, Rotter, Williams, Shi: Lysine-specific demethylase 1: an epigenetic regulator of salt-sensitive hypertension. in American journal of hypertension 2012 (PubMed)
    Show all 2 Pubmed References

  5. Human Polyclonal SCNN1A Primary Antibody for IF (p), IHC (p) - ABIN682243 : Yamamoto, Hotta, Maeda, Kataoka, Maeda, Hamakawa, Sasaki, Yasui, Asai, Kimura: Mineralocorticoid receptor stimulation induces urinary storage dysfunction via upregulation of epithelial sodium channel expression in the rat urinary bladder epithelium. in Journal of pharmacological sciences 2016 (PubMed)

More Antibodies against SCNN1A Interaction Partners

Human Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A) interaction partners

  1. mutation in the extracellular domain of alphaENaC causes Liddle syndrome by increasing intrinsic channel activity.

  2. The mRNA and alpha-ENaC protein were overexpressed in platelets from hypertensive subjects versus control subjects.

  3. The derlin-1 (show DERL1 Antibodies) pathway therefore may represent a significant early checkpoint in the recognition and degradation of ENaC in mammalian cells.

  4. Data show that the expression of aquaporin (AQP) 1, AQP3, AQP5, epithelial Na+ channel (ENaC) and sodium potassium ATPase (Na-K-ATPase) are altered in patients with acute respiratory failure (ARF) due to diffuse alveolar damage (DAD), and the cause of DAD does not seem to influence the level of impairment of these channels.

  5. The data indicate that the Lhs1 chaperone selectively recognizes an immature form of alphaENaC, one which has failed to correctly assemble with the other channel subunits via its transmembrane domain.

  6. LEFTY2 (show LEFTY2 Antibodies) regulates the expression and activity of ENaC in endometrial epithelial cells via SGK1 (show SGK1 Antibodies).

  7. Carriage of the p.W493R-SCNN1A polymorphism has been identified as a risk factor for bronchiectasis, but it is not invariably associated with the phenotype of a hyperactive ENaC channel in the lung.

  8. although subgroup analysis showed alpha-ENaC T663A polymorphism was associated with essential hypertension in North American individuals, these meta-analysis results did not confirm such association overall; conclude that Alpha-ENaC T663A polymorphism might not be a risk factor for essential hypertension

  9. Four nonsynonymous amino acid variants in SCNN1A in nonwhite Cystic fibrosis (show S100A8 Antibodies) patients with non-diagnostic CFTR (show CFTR Antibodies) genotypes was identified.

  10. The rs4149570 and rs7956915 polymorphisms of SCNN1A might play important roles in the susceptibility to respiratory distress syndrome, particularly in term infants.

Mouse (Murine) Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A) interaction partners

  1. The derlin-1 (show DERL1 Antibodies) pathway therefore may represent a significant early checkpoint in the recognition and degradation of ENaC in mammalian cells.

  2. ENaC activity is regulated by calpain-2 (show CAPN2 Antibodies) proteolysis of MARCKS (show MARCKS Antibodies).

  3. nonselective cation channels ( channels consist of at least one alpha-ENaC and one or more acid-sensing ion channel (show ACCN2 Antibodies) 1a (ASIC1a (show ACCN2 Antibodies)) proteins.

  4. ENaC and ROMK (show KCNJ1 Antibodies) channel activity in kidney tubules are inhibited in TgWnk4(pseudoaldosteronism type II) mice. Wnk4 (show WNK4 Antibodies)(PHAII)-induced inhibition of ENaC and ROMK (show KCNJ1 Antibodies) may contribute to the suppression of K(+) secretion in the tubules.

  5. Exosomal GAPDH (show GAPDH Antibodies) from Proximal Tubule Cells Regulate ENaC Activity

  6. depletion of Kir4.1 (show KCNJ10 Antibodies) stimulates the expression of ENaCbeta (show SCNN1B Antibodies) and -gamma subunits in the cortical collecting duct

  7. LEFTY2 (show LEFTY2 Antibodies) regulates the expression and activity of ENaC in endometrial epithelial cells via SGK1 (show SGK1 Antibodies).

  8. reducing ENaC expression in the connecting tubule induces clear pseudohypoaldosteronism type 1 symptoms during high dietary potassium loading

  9. The findings demonstrated a substantial role of mitochondrial dysfunction in mediating the downregulation of NKCC2 (show SLC12A1 Antibodies) and ENaCalpha in obstructive kidney disease, possibly via iNOS (show NOS2 Antibodies)-derived nitric oxide and BNP (show BNC2 Antibodies).

  10. PCSK9 (show PCSK9 Antibodies)(-/-) mice display normal sodium balance and blood pressure regulation despite an increase of cleaved alphaENaC under basal condition

Rabbit Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A) interaction partners

Xenopus laevis Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A) interaction partners

Guinea Pig Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A) interaction partners

  1. Different subunits of ENaC expressed in various cell regions of the cochlea and endolymphatic sac (show ADCY10 Antibodies) in distinct patterns may form the functional sodium channel to regulate the endolymph and maintain homeostasis in inner ear.

SCNN1A Antigen Profile

Protein Summary

Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the alpha subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Gene names and symbols associated with SCNN1A

  • sodium channel epithelial 1 alpha subunit (Scnn1a) antibody
  • sodium channel epithelial 1 alpha subunit (SCNN1A) antibody
  • sodium channel, nonvoltage-gated 1 alpha (Scnn1a) antibody
  • sodium channel, non voltage gated 1 alpha subunit L homeolog (scnn1a.L) antibody
  • alphaxENaC antibody
  • besc2 antibody
  • ENAC antibody
  • enaca antibody
  • ENaCalpha antibody
  • mENaC antibody
  • SCNEA antibody
  • scnn1 antibody
  • SCNN1A antibody

Protein level used designations for SCNN1A

SCNEA , alpha-ENaC , alpha-NaCH , amiloride-sensitive sodium channel subunit alpha , epithelial Na(+) channel subunit alpha , epithelial sodium channel alpha subunit , nonvoltage-gated sodium channel 1 subunit alpha , sodium channel, nonvoltage-gated, type I, alpha , alpha ENaC-2 , amiloride-sensitive epithelial sodium channel alpha subunit , amiloride-sensitive sodium channel subunit alpha 2 , nasal epithelial sodium channel alpha subunit , sodium channel, nonvoltage-gated 1 alpha , ENaC alpha , amiloride-sensitive epithelial sodium channel , sodium channel, nonvoltage-gated, type I, alpha polypeptide , alpha ENaC , epithelial sodium channel ENaC alpha subunit , alpha cENaC 431 , amiloride-sensitve epithelial sodium channel alpha subunit , alpha-subunit renal epithelial sodium channel , epithelium sodium channel alpha subunit , sodium channel, nonvoltage-gated 1, alpha , amiloride-sensitive sodium channel alpha subunit

GENE ID SPECIES
25122 Rattus norvegicus
6337 Homo sapiens
20276 Mus musculus
403650 Canis lupus familiaris
100009488 Oryctolagus cuniculus
397811 Xenopus laevis
282348 Bos taurus
396050 Gallus gallus
396608 Sus scrofa
443488 Ovis aries
451776 Pan troglodytes
100222046 Taeniopygia guttata
100484947 Ailuropoda melanoleuca
100014763 Monodelphis domestica
100135613 Cavia porcellus
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