anti-Sodium Channel, Voltage-Gated, Type III, alpha Subunit (SCN3A) Antibodies

Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. Additionally we are shipping Sodium Channel, Voltage-Gated, Type III, alpha Subunit Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SCN3A 20269  
SCN3A 497770 P08104
SCN3A 6328 Q9NY46
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top anti-Sodium Channel, Voltage-Gated, Type III, alpha Subunit Antibodies at antibodies-online.com

Showing 10 out of 45 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC, IHC (p) Anti-SCN3A / Nav1.3 antibody  ABIN1049320 IHC staining of human spinal cord. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Anti-SCN3A / Nav1.3 antibody IHC of human spinal cord. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated IHC, IHC (p) Anti-SCN3A / Nav1.3 antibody  ABIN1049321 IHC staining of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Anti-SCN3A / Nav1.3 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of extracts of 293T and HT-1080 cells, using SCN3A antibody. Western blot analysis of extracts of various cell lines, using SCN3A antibody (ABIN4905096) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 60s. 100 μL Log in to see 11 to 13 Days
$366.77
Details
Human Rabbit Un-conjugated ELISA, IHC, WB ABIN6273395 at 1/100 staining Human liver cancer tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. Western blot analysis of SCN3A expression in HEK293 cells ,The lane on the left is treated with the antigen-specific peptide. 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated ELISA, WB   100 μL Log in to see 11 to 13 Days
$335.04
Details
Human Rabbit Un-conjugated IHC (p) 50 μg Log in to see 12 to 14 Days
$686.14
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (36.74 KDa) . 100 μg Log in to see 11 to 12 Days
$440.00
Details
Human Rabbit Un-conjugated IHC (p) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) of human spinal cord tissue with SCN3A polyclonal antibody . Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 11 to 12 Days
$577.33
Details
Human Rabbit Un-conjugated ELISA, IF, WB   100 μg Log in to see 6 to 7 Days
$532.46
Details
Rat Rabbit Un-conjugated IHC, WB   50 μL Log in to see 11 to 16 Days
$741.71
Details

More Antibodies against Sodium Channel, Voltage-Gated, Type III, alpha Subunit Interaction Partners

Mouse (Murine) Sodium Channel, Voltage-Gated, Type III, alpha Subunit (SCN3A) interaction partners

  1. enterochromaffin (EC) cells use Scn3a-encoded voltage-gated sodium channel NaV1.3 for electrical excitability and 5-HT release. NaV1.3-dependent electrical excitability and its contribution to 5-HT release is a novel mechanism of EC cell function

  2. Novel de novo variant SCN3A-L247P was demonstrated to cause a defect in trafficking, which would be predicted to functionally reduce SCN3A activity. Consistent with the clinical observations, Scn3a+/Hyp mice display increased seizure susceptibility, hypoactivity, and impaired motor learning.

  3. Scn3a was mapped to the QTL for febrile seizure susceptibility.

  4. a huge difference in electrophysiological function between SCN1A and SCN3A mutations in the pore region; this might explain the more common SCN1A mutations detected in patients with epilepsy and the more severe phenotypes associated with these mutations

  5. these findings suggest that CpG methylation and MBD2 are involved in altering Scn3a expression during postnatal development and seizure condition.

  6. the time course of declining expression of the murine embryonic sodium channel Nav 1.3 and the rise in expression of the adult sodium channel Nav 1.1 with susceptibility to epileptic seizures and increased incidence of sudden death

  7. These results suggest that the GC box and CpG methylation might play important roles in regulating mouse Scn3a gene expression.

  8. These data demonstrate that Nav1.3 is neither necessary nor sufficient for the development of nerve-injury related pain.

  9. SCN2A, SCN3A, and SCN9A are expressed beneath tight junctions in subsets of taste cells. SCN3A and SCN9A are expressed in TRPM5 cells, while SCN2A was expressed in TRPM5 and PKD2L1 cells.

Human Sodium Channel, Voltage-Gated, Type III, alpha Subunit (SCN3A) interaction partners

  1. Study represents the first evidence of the abnormal changes in voltage-gated sodium channels subtypes (including Nav1.3) and CaM/CaMKII pathway in human brain low-grade astrocytoma, providing new potential targets for molecular therapies of this disease.

  2. SCN3A is involved in development of the human brain and oral motor development. When SCN3A is mutated, patients present with polymicrogyria and speech deficits.

  3. Novel de novo variant SCN3A-L247P was demonstrated to cause a defect in trafficking, which would be predicted to functionally reduce SCN3A activity. Consistent with the clinical observations, Scn3a+/Hyp mice display increased seizure susceptibility, hypoactivity, and impaired motor learning.

  4. sodium channel currents in oocytes expressing either wild-type or mutant (A4V) SOD1 protein

  5. Data indicate eight new cases with overlapping duplications at 2q24 and SCN3A was not involved in duplication, suggesting that having an extra copy of SCN2A has an effect on epilepsy pathogenesis.

  6. the time course of declining expression of the murine embryonic sodium channel Nav 1.3 and the rise in expression of the adult sodium channel Nav 1.1 with susceptibility to epileptic seizures and increased incidence of sudden death

  7. Discovery of a common biophysical defect among variants identified in unrelated pediatric epilepsy patients suggests that SCN3A may contribute to neuronal hyperexcitability and epilepsy.

  8. sodium channel polymorphisms are associated with epilepsy

  9. Our data from the Hong Kong and Malaysia cohorts showed no significant allele, genotype and haplotype association of polymorphisms in the SCN1A, SCN2A, and SCN3A genes with drug responsiveness in epilepsy.

  10. This study demonistrated that associated with a duplication of the SCN2A and SCN3A gene cluster on 2q24 in patient with early onset epilepsy.

  11. Upregulation of Nav1.3 protein and a specific cellular distribution of Nav1.3 proteins in focal cortical dysplasia type IIb(FCDIIb) lesion tissue samples suggest that Nav1.3 may be involved in the generation of epileptic activity in FCDIIb.

  12. Deletions in SCN3A gene is associated with autistic features and developmental delay.

  13. In trigeminal neuralgia (TN) there is a reduction in the expression of Nav1.7 and an increase in the expression of Nav1.3, Nav1.8 expression not significantly different; TN can be, at least in part, a channelopathy.

  14. in autism families, two polymorphic coding variants of SCN3A are described

  15. Characterization of 5' untranslated regions SCN3A, and identification of cis-conserved noncoding sequences.

  16. The association of antiepileptic drugs responsiveness with genetic polymorphisms was investigated and any association with mRNA expression of the neuronal sodium channels was correlated.

Sodium Channel, Voltage-Gated, Type III, alpha Subunit (SCN3A) Antigen Profile

Protein Summary

Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is found in a cluster of five alpha subunit genes on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SCN3A

  • sodium voltage-gated channel alpha subunit 3 (SCN3A) antibody
  • sodium channel, voltage gated, type III alpha subunit (scn3a) antibody
  • sodium channel protein type 9 subunit alpha (LOC100180733) antibody
  • sodium channel, voltage-gated, type III, alpha (Scn3a) antibody
  • sodium voltage-gated channel alpha subunit 3 (Scn3a) antibody
  • sodium channel protein type 3 subunit alpha (LOC534223) antibody
  • Gm1000 antibody
  • NAC3 antibody
  • Nav1.3 antibody
  • SCIII antibody
  • Scn2a antibody
  • SCN3A antibody

Protein level used designations for SCN3A

sodium channel, voltage-gated, type III, alpha subunit , sodium channel, voltage-gated, type III, alpha polypeptide , sodium channel protein brain III subunit alpha , sodium channel protein type 3 subunit alpha , sodium channel protein type III subunit alpha , sodium channel protein, brain III subunit alpha , sodium channel, voltage-gated, type 3, alpha subunit , voltage-gated sodium channel subtype III , voltage-gated sodium channel subunit alpha Nav1.3 , brain III voltage-gated sodium channel , voltage-dependent sodium channel SCN3A

GENE ID SPECIES
459699 Pan troglodytes
478772 Canis lupus familiaris
100125099 Xenopus (Silurana) tropicalis
100180733 Ciona intestinalis
20269 Mus musculus
497770 Rattus norvegicus
6328 Homo sapiens
424180 Gallus gallus
534223 Bos taurus
Selected quality suppliers for anti-Sodium Channel, Voltage-Gated, Type III, alpha Subunit (SCN3A) Antibodies
Did you look for something else?