anti-Sodium Channel, Voltage-Gated, Type III, alpha Subunit (SCN3A) Antibodies

Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. Additionally we are shipping Sodium Channel, Voltage-Gated, Type III, alpha Subunit Proteins (6) and many more products for this protein.

Gene Name	GeneID	UniProt
SCN3A	20269
SCN3A	497770	P08104
SCN3A	6328	Q9NY46

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Top anti-Sodium Channel, Voltage-Gated, Type III, alpha Subunit Antibodies at antibodies-online.com

Showing 10 out of 46 products:

Catalog No.	Reactivity	Host	Conjugate	Application	Quantity	Supplier	Delivery	Price	Details
ABIN393332	Human	Mouse	Un-conjugated	ELISA, WB	100 μg	Log in to see	8 to 11 Days	$461.00	Details
ABIN1049320	Human	Rabbit	Un-conjugated	IHC, IHC (p)	50 μg	Log in to see	11 to 14 Days	$484.00	Details
ABIN1049321	Human	Rabbit	Un-conjugated	IHC, IHC (p)	50 μg	Log in to see	11 to 14 Days	$484.00	Details
ABIN4905096	Human	Rabbit	Un-conjugated	WB	100 μL	Log in to see	16 Days	$334.77	Details
ABIN6284382	Human	Rabbit	Un-conjugated	ELISA, WB	200 μL	Log in to see	16 Days	$221.38	Details
ABIN1739061	Human	Rabbit	Un-conjugated	IHC (p)	50 μg	Log in to see	12 to 14 Days	$685.40	Details
ABIN520022	Human	Mouse	Un-conjugated	ELISA, WB	100 μg	Log in to see	11 to 12 Days	$440.00	Details
ABIN5587501	Human	Rabbit	Un-conjugated	IHC (p)	50 μg	Log in to see	11 to 12 Days	$460.00	Details
ABIN1828841	Human	Mouse	Un-conjugated	ELISA, WB	100 μg	Log in to see	7 to 9 Days	$537.17	Details
ABIN4889527	Human	Rabbit	Un-conjugated	ELISA, IF, WB	100 μg	Log in to see	6 to 7 Days	$532.07	Details

More product categories related to Sodium Channel, Voltage-Gated, Type III, alpha Subunit Antibody

More Antibodies against Sodium Channel, Voltage-Gated, Type III, alpha Subunit Interaction Partners

Mouse (Murine) Sodium Channel, Voltage-Gated, Type III, alpha Subunit (SCN3A) interaction partners

Novel de novo variant SCN3A-L247P was demonstrated to cause a defect in trafficking, which would be predicted to functionally reduce SCN3A activity. Consistent with the clinical observations, Scn3a+/Hyp (show PHEX Antibodies) mice display increased seizure susceptibility, hypoactivity, and impaired motor learning.
Scn3a was mapped to the QTL for febrile seizure susceptibility.
a huge difference in electrophysiological function between SCN1A (show SCN1A Antibodies) and SCN3A mutations in the pore region; this might explain the more common SCN1A (show SCN1A Antibodies) mutations detected in patients with epilepsy and the more severe phenotypes associated with these mutations
these findings suggest that CpG methylation and MBD2 (show MBD2 Antibodies) are involved in altering Scn3a expression during postnatal development and seizure condition.
These results suggest that the GC box and CpG methylation might play important roles in regulating mouse Scn3a gene expression.
These data demonstrate that Nav1.3 is neither necessary nor sufficient for the development of nerve-injury related pain.
SCN2A (show SCN2A Antibodies), SCN3A, and SCN9A (show SCN9A Antibodies) are expressed beneath tight junctions in subsets of taste cells. SCN3A and SCN9A (show SCN9A Antibodies) are expressed in TRPM5 (show TRPM5 Antibodies) cells, while SCN2A (show SCN2A Antibodies) was expressed in TRPM5 (show TRPM5 Antibodies) and PKD2L1 (show PKD2L1 Antibodies) cells.

Human Sodium Channel, Voltage-Gated, Type III, alpha Subunit (SCN3A) interaction partners

SCN3A is involved in development of the human brain and oral motor development. When SCN3A is mutated, patients present with polymicrogyria and speech deficits.
Novel de novo variant SCN3A-L247P was demonstrated to cause a defect in trafficking, which would be predicted to functionally reduce SCN3A activity. Consistent with the clinical observations, Scn3a+/Hyp (show PHEX Antibodies) mice display increased seizure susceptibility, hypoactivity, and impaired motor learning.
sodium channel currents in oocytes expressing either wild-type or mutant (A4V) SOD1 (show SOD1 Antibodies) protein
Data indicate eight new cases with overlapping duplications at 2q24 and SCN3A was not involved in duplication, suggesting that having an extra copy of SCN2A (show SCN2A Antibodies) has an effect on epilepsy pathogenesis.
Discovery of a common biophysical defect among variants identified in unrelated pediatric epilepsy patients suggests that SCN3A may contribute to neuronal hyperexcitability and epilepsy.
Our data from the Hong Kong and Malaysia cohorts showed no significant allele, genotype and haplotype association of polymorphisms in the SCN1A (show SCN1A Antibodies), SCN2A (show SCN2A Antibodies), and SCN3A genes with drug responsiveness in epilepsy.
This study demonistrated that associated with a duplication of the SCN2A (show SCN2A Antibodies) and SCN3A gene cluster on 2q24 in patient with early onset epilepsy.
Upregulation of Nav1.3 protein and a specific cellular distribution of Nav1.3 proteins in focal cortical dysplasia type IIb(FCDIIb) lesion tissue samples suggest that Nav1.3 may be involved in the generation of epileptic activity in FCDIIb.
Deletions in SCN3A gene is associated with autistic features and developmental delay.
In trigeminal neuralgia (TN) there is a reduction in the expression of Nav1.7 (show SCN9A Antibodies) and an increase in the expression of Nav1.3, Nav1.8 (show SCN10A Antibodies) expression not significantly different; TN can be, at least in part, a channelopathy.

Sodium Channel, Voltage-Gated, Type III, alpha Subunit (SCN3A) Antigen Profile

Protein Summary

Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is found in a cluster of five alpha subunit genes on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SCN3A

sodium voltage-gated channel alpha subunit 3 (SCN3A) antibody
sodium channel, voltage gated, type III alpha subunit (scn3a) antibody
sodium channel protein type 9 subunit alpha (LOC100180733) antibody
sodium channel, voltage-gated, type III, alpha (Scn3a) antibody
sodium voltage-gated channel alpha subunit 3 (Scn3a) antibody
sodium channel protein type 3 subunit alpha (LOC534223) antibody

Gm1000 antibody
NAC3 antibody
Nav1.3 antibody
SCIII antibody
Scn2a antibody
SCN3A antibody

Protein level used designations for SCN3A

sodium channel, voltage-gated, type III, alpha subunit , sodium channel, voltage-gated, type III, alpha polypeptide , sodium channel protein brain III subunit alpha , sodium channel protein type 3 subunit alpha , sodium channel protein type III subunit alpha , sodium channel protein, brain III subunit alpha , sodium channel, voltage-gated, type 3, alpha subunit , voltage-gated sodium channel subtype III , voltage-gated sodium channel subunit alpha Nav1.3 , brain III voltage-gated sodium channel , voltage-dependent sodium channel SCN3A

GENE ID	SPECIES
459699	Pan troglodytes
478772	Canis lupus familiaris
100125099	Xenopus (Silurana) tropicalis
100180733	Ciona intestinalis
20269	Mus musculus
497770	Rattus norvegicus
6328	Homo sapiens
424180	Gallus gallus
534223	Bos taurus

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