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facilitates sodium dependent transport of Krebs cycle intermediates including citrate, succinate, alpha-ketoglutarate, and oxaloacetate [RGD, Feb 2006].. Additionally we are shipping Solute Carrier Family 13 Member 2 Proteins (5) and Solute Carrier Family 13 Member 2 Kits (1) and many more products for this protein.
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Human Polyclonal SLC13A2 Primary Antibody for ELISA, WB - ABIN522497
Bergeron, Bürzle, Kovacs, Simonin, Hediger: Synthesis, maturation, and trafficking of human Na+-dicarboxylate cotransporter NaDC1 requires the chaperone activity of cyclophilin B. in The Journal of biological chemistry 2011
Results point to an epistatic interaction between the VDR (show CYP27B1 Antibodies) and the SLC13A2 alleles in the pathogenesis of idiopathic hypocitraturia in calcium-oxalate stone formers.
High-Mobility Group Box 1 Upregulates MUC5AC and MUC5B Expression in Primary Airway Epithelial Cells
Cyclic pressure did not induce MUC5AC secretion in the airway mucus epithelium via Ca(2 (show CA2 Antibodies)+)-dependent ATP release, and nearly all Ca(2 (show CA2 Antibodies)+) was provided by stored intracellular Ca(2 (show CA2 Antibodies)).
IL-33 (show IL33 Antibodies) induced MUC5AC mRNA and MUC5AC protein, and also goblet cell hyperplasia at air liquid interface culture in human nasal epithelial cells. In addition to that, IL-33 (show IL33 Antibodies) induced MUC5B and FOXA3 (show FOXA3 Antibodies), and reduces FOXJmRNA.
MUC5AC has pathologic roles in mechanisms of allergen-induced airway hyperresponsiveness, mucous metaplasia, and airway mucus plugging.
Leptin (show LEP Antibodies) knockdown suppressed MUC5AC production and secretion induced by IL-13 (show IL13 Antibodies) in human bronchial epithelial cells.
The results suggest that the analysis of expression of MUC5AC and TFF1 (show TFF1 Antibodies) may be useful for differentiating sessile serrated adenomas/polyps (SSA (show TRIM21 Antibodies)/Ps) from hyperplastic polyps (HPs (show HPS1 Antibodies)).
The Egr-1 (show EGR1 Antibodies) is essential for CSE (show CSE Antibodies)-induced MUC5AC production in HBE (show HBe1 Antibodies) cells likely through interaction with and modulation of AP-1 (show FOSB Antibodies), and re-emphasize targeting Egr-1 (show EGR1 Antibodies) as a novel therapeutic strategy for COPD (show ARCN1 Antibodies).
Mucus plugs from individuals with fatal asthma are heterogeneous gels with distinct MUC5AC- and MUC5B-containing domains. Tethering of MUC5AC-containing domains to the epithelium causes mucostasis and likely represents a major cause of mucus plugging in asthma.
The only individual marker that was found to have direct and strong correlation with the clinical outcome of ampullary carcinoma was MUC5AC (not used in the Ang or Chang panels), with statistically significant survival differences found with various cutoffs tested (for 20% cutoff, 5-y survival, 68% vs. 31%; P=0.0002). In addition, MUC5AC significantly stratified the histologically pancreatobiliary and intestinal cases.
Slc26a6 (show SLC26A6 Antibodies)-null mice exhibit increased renal and intestinal sodium-dependent succinate uptake, as well as urinary hyperoxaluria and hypocitraturia, but no change in urinary pH, indicating enhanced transport activity of NaDC-1.
The acid-activated pathway mediating stimulation of kidney NaDC-1 activity requires a functional ET(B (show EDNRB Antibodies)) receptor in vivo and in vitro.
Substrate-dependent inward currents, measured using two-electrode voltage clamp, were similar for glutarate & succinate in Xenopus oocytes expressing mouse NaDC1. Currents evoked by glutarate in rabbit NaDC1 were about 5% of succinate-dependent currents.
Sodium dicarboxylate cotransporter is involved in regulating levels of various Krebs cycle intermediates in the kidney, although impaired uptake of these intermediates does not significantly affect renal function under normal or ischemic stress.
Mapping Functionally Important Residues in the Na(+)/Dicarboxylate Cotransporter, NaDC1.
Data show that NaDC1 F336C had increased transport activity due to an increased Vmax for succinate.
facilitates sodium dependent transport of Krebs cycle intermediates including citrate, succinate, alpha-ketoglutarate, and oxaloacetate
Na(+)-coupled citrate transporter
, Na(+)/dicarboxylate cotransporter 1
, renal sodium/dicarboxylate cotransporter
, solute carrier family 13 member 2
, intestinal sodium/dicarboxylate cotransporter
, sodium-dependent dicarboxylate transporter
, solute carrier family 13, member 2
, solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
, sodium/dicarboxylate co-transporter
, sodium/dicarboxylate cotransporter
, mucin 2, intestinal/tracheal
, solute carrier family 13 (sodium-dependent citrate transporter), member 5 L homeolog