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facilitates sodium dependent transport of Krebs cycle intermediates including citrate, succinate, alpha-ketoglutarate, and oxaloacetate [RGD, Feb 2006].. Additionally we are shipping Solute Carrier Family 13 Member 2 Proteins (5) and and many more products for this protein.
Showing 10 out of 40 products:
Human Polyclonal SLC13A2 Primary Antibody for ELISA, WB - ABIN522497
Bergeron, Bürzle, Kovacs, Simonin, Hediger: Synthesis, maturation, and trafficking of human Na+-dicarboxylate cotransporter NaDC1 requires the chaperone activity of cyclophilin B. in The Journal of biological chemistry 2011
Homozygous GG of rs11567842 SNP in NaDC-1 gene was a protective genotype for hypocitraturia in kidney stone patients
Results point to an epistatic interaction between the VDR and the SLC13A2 alleles in the pathogenesis of idiopathic hypocitraturia in calcium-oxalate stone formers.
Mapping Functionally Important Residues in the Na(+)/Dicarboxylate Cotransporter, NaDC1.
NaDC1 is present throughout the entire proximal tubule, but was not detected in kidney tumors.
cyclophilin isoform B is likely responsible for down-regulation of carrier expression by CsA and that it does so via its chaperone activity on NaDC1 (by direct interaction) rather than its rotamase activity.
study concludes most of the naturally occurring nonsynonymous SNPs affect protein processing of NaDC1; several also affect functional properties; mutations are predicted to decrease transport activity
This paper describes the cloning and functional characterization of the human Na(+)-coupled citrate transporter (NaCT).
Data show that the sodium-dependent dicarboxylate co-transporter protein 1 is located in renal proximal tubule lumenal membranes, and that the C-terminal sequence is required for delivery and targeting and may contain the signal sequence.
there are conformationally sensitive residues in extracellular loop 5 of the Na+/dicarboxylate co-transporter
B allele of I550V polymorphism of hNaDC-1 may be associated with a reduction in urinary citrate excretion and contribute to hypocitraturia in recurrent renal stone formers.
The Ser or Thr at position 509 is the most important determinant of functional differences in apparent affinity for substrate and cations. The cation and substrate binding sites are located in close proximity to one another.
Slc26a6-null mice exhibit increased renal and intestinal sodium-dependent succinate uptake, as well as urinary hyperoxaluria and hypocitraturia, but no change in urinary pH, indicating enhanced transport activity of NaDC-1.
The acid-activated pathway mediating stimulation of kidney NaDC-1 activity requires a functional ET(B) receptor in vivo and in vitro.
Substrate-dependent inward currents, measured using two-electrode voltage clamp, were similar for glutarate & succinate in Xenopus oocytes expressing mouse NaDC1. Currents evoked by glutarate in rabbit NaDC1 were about 5% of succinate-dependent currents.
Sodium dicarboxylate cotransporter is involved in regulating levels of various Krebs cycle intermediates in the kidney, although impaired uptake of these intermediates does not significantly affect renal function under normal or ischemic stress.
Data show that NaDC1 F336C had increased transport activity due to an increased Vmax for succinate.
facilitates sodium dependent transport of Krebs cycle intermediates including citrate, succinate, alpha-ketoglutarate, and oxaloacetate
Na(+)-coupled citrate transporter
, Na(+)/dicarboxylate cotransporter 1
, renal sodium/dicarboxylate cotransporter
, solute carrier family 13 member 2
, intestinal sodium/dicarboxylate cotransporter
, sodium-dependent dicarboxylate transporter
, solute carrier family 13, member 2
, solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
, sodium/dicarboxylate co-transporter
, sodium/dicarboxylate cotransporter
, solute carrier family 13 (sodium-dependent citrate transporter), member 5 L homeolog