Solute Carrier Family 22 (Organic Anion/urate Transporter), Member 12 (SLC22A12) ELISA Kits

The protein encoded by SLC22A12 is a urate transporter and urate-anion exchanger which regulates the level of urate in the blood. Additionally we are shipping Solute Carrier Family 22 (Organic Anion/urate Transporter), Member 12 Antibodies (32) and Solute Carrier Family 22 (Organic Anion/urate Transporter), Member 12 Proteins (5) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Mouse SLC22A12 SLC22A12 20521 Q8CFZ5
SLC22A12 116085 Q96S37
SLC22A12 365398 Q3ZAV1
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Top Solute Carrier Family 22 (Organic Anion/urate Transporter), Member 12 ELISA Kits at antibodies-online.com

Showing 4 out of 12 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 11.72 pg/mL 46.88-3000 pg/mL Typical standard curve 96 Tests Log in to see 15 to 18 Days
$910.56
Details
Rat 0.267 ng/mL 0.62 ng/mL - 40 ng/mL 96 Tests Log in to see 13 to 16 Days
$800.00
Details
Human < 0.127 ng/mL 0.312 ng/mL - 20 ng/mL   96 Tests Log in to see 11 to 18 Days
$810.17
Details
Rat < 0.267 ng/mL 0.625 ng/mL - 40 ng/mL   96 Tests Log in to see 11 to 18 Days
$867.02
Details

More ELISA Kits for Solute Carrier Family 22 (Organic Anion/urate Transporter), Member 12 Interaction Partners

Mouse (Murine) Solute Carrier Family 22 (Organic Anion/urate Transporter), Member 12 (SLC22A12) interaction partners

  1. Urat1-Uox double knockout mice are a suitable animal model for renal hypouricemia.

  2. Immunostaining and highly-sensitive in situ hybridization was used to assess the distribution of UA transporters: GLUT9/URATv1 (show SLC2A9 ELISA Kits), ABCG2, and URAT1. Immunostaining for GLUT9 (show SLC2A9 ELISA Kits) was observed in ependymal cells, neurons, and brain capillaries. Immunostaining for ABCG2 was observed in the choroid plexus epithelium and brain capillaries, but not in ependymal cells. These results were validated by in situ hybridization.

  3. The cause of obesity/metabolic syndrome-associated hyperuricemia appears to be associated with the urate reabsorption transporter Urat1 protein enhanced by fat.

  4. Although the fractional excretion of urate of knockout mice was tend to higher than that of wildtype mice, the urate reabsorption ability remained in the kidney of knockout mice, indicating a urate reabsorptive transporter other than Urat1.

  5. mouse RST mediates the efflux of organic anions including urate and works as exit for organic anions in the proximal tubules

  6. NHERF-1 exerts a significant effect on the renal tubular reabsorption of uric acid in the mouse by modulating the brush Border membrane abundance of mURAT1.

Human Solute Carrier Family 22 (Organic Anion/urate Transporter), Member 12 (SLC22A12) interaction partners

  1. The rs475688 polymorphism is associated with gout susceptibility. The correlation between rs3825016 polymorphism of SLC22A12 and hyperuricaemia susceptibility is possible. [Meta-Analysis]

  2. Combined exposure to the four high-risk genotypes of ALPK1 and the uric-acid-related loci of ABCG2, SLC2A9, and SLC22A12 was associated with an increased gout risk and a high PPV for gout.

  3. Human-rat transporter chimeras revealed that human URAT1 serine-35, phenylalanine-365 and isoleucine-481 are necessary and sufficient to provide up to a 100-fold increase in affinity for inhibitors. Moreover, serine-35 and phenylalanine-365 are important for high-affinity interaction with the substrate urate.

  4. Immunoreactivity of URAT1 was observed on the basolateral side of the cytoplasm of epithelial cells in the choroid plexus.

  5. A meta-analysis of all gout with Japanese, Caucasian and NZ Polynesian populations revealed that rs2285340 of SLC22A12 and rs1165196 of SLC17A1 showed a significant association but did not reach a genome-wide significance level.

  6. The present proof-of-principle paper demonstrates that the multilocus profiles of ABCG2, SLC2A9 (show SLC2A9 ELISA Kits) and SLC22A12 increase susceptibility to asymptomatic hyperuricaemia, gout and tophi.

  7. The common dysfunction allelic variants of URAT1 exist in the general Roma population and thus renal hypouricemia should be kept in differential diagnostic algorithm on Roma patients with defect in renal tubular urate transport.

  8. URAT1 nonfunctional variants are protective genetic factors for gout/hyperuricemia, and also demonstrated the sex-dependent effect size of these URAT1 variants on serum uric acid (P for interaction = 1.5 x 10(-12)).

  9. These results suggest that URAT1 rs3825016 and rs1529909 polymorphisms influence the uricosuric action of losartan

  10. Depletion of UA due to SLC22A12/URAT1 loss-of-function mutations causes endothelial dysfunction in hypouricemia patients.

Solute Carrier Family 22 (Organic Anion/urate Transporter), Member 12 (SLC22A12) Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the organic anion transporter (OAT) family, and it acts as a urate transporter to regulate urate levels in blood. This protein is an integral membrane protein primarily found in epithelial cells of the proximal tubule of the kidney. An elevated level of serum urate, hyperuricemia, is associated with increased incidences of gout, and mutations in this gene cause renal hypouricemia type 1. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with SLC22A12

  • solute carrier family 22 (organic anion/cation transporter), member 12 (Slc22a12) antibody
  • solute carrier family 22 member 12 (SLC22A12) antibody
  • solute carrier family 22 member 12 (Slc22a12) antibody
  • AI987855 antibody
  • OAT4L antibody
  • RST antibody
  • Slc22al2 antibody
  • URAT1 antibody

Protein level used designations for SLC22A12

renal-specific transporter , solute carrier family 22 (organic cation transporter)-like 2 , solute carrier family 22 member 12 , urate anion exchanger 1 , organic anion transporter 4-like protein , solute carrier family 22 (organic anion/cation transporter), member 12 , urate transporter 1

GENE ID SPECIES
20521 Mus musculus
116085 Homo sapiens
365398 Rattus norvegicus
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