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The protein encoded by SLC22A11 is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic.
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The first genome-wide association study for serum uric acid level in Indians revealed association of SLC2A9, SLC22A11 and ABCG2 gene variants at genome wide significance level in Type 2 diabetes patients.
The regulation of hOAT4 (show SLC22A9 Proteins) activity was mediated by sgk2 (show SGK2 Proteins) acting through Nedd4-2 (show NEDD4L Proteins).
SLC22A11 at the basal plasma membrane of human placental syncytiotrophoblasts plays a predominant role in the uptake of 16alpha-OH DHEAS (show SULT2A1 Proteins) for placental estriol synthesis.
Our analysis provides evidence for multiple ancestral-specific effects across the SLC22A11/SLC22A12 (show SLC22A12 Proteins) locus that presumably influence the activity of OAT4 (show SLC22A9 Proteins) and URAT1 (show SLC22A12 Proteins) and risk of gout.
When investigating the genes separately, SLC22A11 and SLC2A9 showed a significant interaction, consistent with the former encoding an organic anion/dicarboxylate exchanger, which mediates diuretic transport in the kidney.
Genetic variants of human organic anion transporter 4 (show SLC22A9 Proteins) demonstrate altered transport of endogenous substrates.
The down-regulation of hOAT4 (show SLC22A9 Proteins) activity by activation of protein kinase C and the up-regulation of hOAT4 (show SLC22A9 Proteins) activity by NHERF-1 (show SLC9A3R1 Proteins) are mediated through alteration of hOAT4 (show SLC22A9 Proteins) internalization.
Glycosylation serves as a means to specifically regulate hOAT4 (show SLC22A9 Proteins) function in vivo.
hOAT4 (show SLC22A9 Proteins) is the long-postulated, low-affinity apical urate anion exchanger that facilitates hydrochlorothiazide-associated hyperuricemia.
The interaction of PDZ proteins with hOAT4 (show SLC22A9 Proteins) may be cell-specific. In placenta, a different set of interacting proteins from PDZK1 (show PDZK1 Proteins) and NHERF1 (show SLC9A3R1 Proteins) may be required to modulate hOAT4 (show SLC22A9 Proteins) activity.
The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and is found mainly in the kidney and in the placenta, where it may act to prevent potentially harmful organic anions from reaching the fetus.
solute carrier family 22 (organic anion/urate transporter), member 11
, solute carrier family 22 member 11
, solute carrier family 22 (organic anion/cation transporter), member 11
, organic anion transporter 4