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The protein encoded by SLC31A1 is a high-affinity copper transporter found in the cell membrane. Additionally we are shipping Solute Carrier Family 31 (Copper Transporters), Member 1 Antibodies (76) and Solute Carrier Family 31 (Copper Transporters), Member 1 Kits (20) and many more products for this protein.
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Arabidopsis COPT1 overexpression (C1 (OE) ) in rice causes root shortening in high copper conditions and under iron deficiency.
Data indicate that cadmium (Cd) elicits SPL7-dependent copper (Cu) deficiency responses by altering expression of COPT1, COPT2, COPT6, CSD1, CSD2 (show TGFB1 Proteins), miRNA398 b/c precursors and FSD1 (show FSD1 Proteins).
Col (show HDAC1 Proteins)-0, high-affinity copper transporter COPT1-overexpressing (C1(OE)) seedlings and T-DNA COPT1 insertion mutant (copt1) differ in their copper-transport activity. C1(OE) showed a fivefold higher Cu-induced K(+) efflux at the root tip compared with Col (show HDAC1 Proteins)-0.
combination of desferal with oxaliplatin can overcome cervical cancer oxaliplatin resistance through the regulation of hCtr1 and TfR1 (show TFRC Proteins)
Study showed that NEAT1 could function as a competing endogenous lncRNA in lung cancer, mediating CTR1 by sponging hsa (show CD24 Proteins)-mir (show MLXIP Proteins)-98-5p.
This result indicates that the formation of copper-finger protein of Sp1 (show PSG1 Proteins) is the molecular basis of copper sensing for the transcriptional regulation of hCtr1 in mammalian cells.
we assessed the role of miR (show MLXIP Proteins)-21 in mediating renal cell carcinoma (show MOK Proteins) chemoresistance and further showed that miR (show MLXIP Proteins)-21 silencing significantly (1) increased chemosensitivity of paclitaxel, 5-fluorouracil, oxaliplatin, and dovitinib; (2) decreased expression of multi-drug resistance genes; and (4) increased SLC22A1/OCT1, SLC22A2/OCT2 (show SLC22A2 Proteins), and SLC31A1/CTR1 platinum influx transporter expression
Gene duplication and neo-functionalization in the evolutionary and functional divergence of the metazoan copper transporters Ctr1 and Ctr2
It has been demonstrated in ovarian cancer cells that cisplatin resistance and uptake correlates with reduced CTR1 and LRRC8A (show LRRC8A Proteins) protein expression/activity and a concomitant upregulation in cisplatin exporting transporters (ATP7A (show ATP7A Proteins), ATP7B (show ATP7B Proteins)), which implies that the resistant cells have a reduced ability to accumulate cisplatin and activate proapoptotic transporters for osmolytes.
CTR1 recycling via clathrin-mediated and Rab11 pathways enable cells to dynamically modulate copper entry
C-Terminus of Human Copper Importer Ctr1 Acts as a Binding Site and Transfers Copper to Atox1 (show ATOX1 Proteins)
Studied the interaction of CTR1 and CTR2 in fully malignant HEK293T and OVCAR8 human ovarian cancer cells using a CRISPR-Cas9 knock out system.
High CTR1 Expression is associated with poor response to chemotherapy in Muscle-invasive Bladder Cancer.
Studies show that zebrafish ctr1 is an essential gene for development.
studies identify a new processing event and the key protease that cleaves the Ctr1 metal-binding ectodomain, which functions to regulate cellular Cu(+) and cisplatin acquisition
CTR1, ATP7A (show ATP7A Proteins), and lysyl oxidase (show LOX Proteins) were upregulated in the lung tissues and pulmonary arteries of mice with hypoxia-induced pulmonary hypertension and pulmonary arterial smooth muscle cells.
conclude that Y103 is required for the internalization of hCTR1 in response to Cu, that this occurs by a mechanism other than phosphorylation and that mutation of Y103 modulates the interaction with IRS-4 (show IRS4 Proteins)
A key regulatory mechanism for mammalian copper transport is through Ctr2-dependent accumulation of a Ctr1 variant lacking the copper- and cisplatin-binding ecto (show TRIM33 Proteins)-domain.
conclude that Cu acquired from CTR1 is required for signaling in pathways regulated by RTKs that play major roles in development and cance
There was little difference in rates/kinetics of uptake of copper in the Ctr1+/+ and -/- cells. Endocytosis was not involved.
basal expression of Ctr1 is regulated by HIF2alpha (show EPAS1 Proteins); however, the induction by hypoxia is a HIF2alpha (show EPAS1 Proteins)-independent event
Structure-functional organization of eukaryotic high-affinity copper importer CTR1 determines its ability to transport copper, silver and cisplatin
Data show apical localization of Ctr1 in intestinal epithelia and suggest that increased Ctr1 apical localization in response to dietary copper limitation may represent an adaptive response to modulate Ctr1 availability at the site of copper absorption.
The protein encoded by this gene is a high-affinity copper transporter found in the cell membrane. The encoded protein functions as a homotrimer to effect the uptake of dietary copper.
solute carrier family 31 (copper transporters), member 1
, high affinity copper uptake protein 1
, Copper transporter 1
, copper transporter 1
, solute carrier family 31 member 1
, copper transport 1 homolog
, Copper uptake transporter 1
, liver regeneration-related protein LRRGT00200
, high affinity copper uptake protein
, solute carrier family 13 (sodium/sulphate symporters), member 1