Solute Carrier Family 31 (Copper Transporters), Member 1 Proteins (SLC31A1)

The protein encoded by SLC31A1 is a high-affinity copper transporter found in the cell membrane. Additionally we are shipping Solute Carrier Family 31 (Copper Transporters), Member 1 Antibodies (81) and Solute Carrier Family 31 (Copper Transporters), Member 1 Kits (20) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLC31A1 1317 O15431
Rat SLC31A1 SLC31A1 171135 Q9JK41
SLC31A1 20529 Q8K211
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Top Solute Carrier Family 31 (Copper Transporters), Member 1 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$5,262.31
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Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
$7,493.38
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Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 11 to 18 Days
$582.75
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Escherichia coli (E. coli) Chemical Un-conjugated   5 applications Log in to see 1 to 2 Days
$318.85
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SLC31A1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

Mouse (Murine)

More Proteins for Solute Carrier Family 31 (Copper Transporters), Member 1 (SLC31A1) Interaction Partners

Cow (Bovine) Solute Carrier Family 31 (Copper Transporters), Member 1 (SLC31A1) interaction partners

  1. The results obtained in the present study determined that cupremia levels at the beginning of FTAI protocol did not influence the pregnancy rates at 60 d after insemination.

Arabidopsis thaliana Solute Carrier Family 31 (Copper Transporters), Member 1 (SLC31A1) interaction partners

  1. Arabidopsis COPT1 overexpression (C1 (OE) ) in rice causes root shortening in high copper conditions and under iron deficiency.

  2. Data indicate that cadmium (Cd) elicits SPL7-dependent copper (Cu) deficiency responses by altering expression of COPT1, COPT2, COPT6, CSD1, CSD2, miRNA398 b/c precursors and FSD1.

  3. Col-0, high-affinity copper transporter COPT1-overexpressing (C1(OE)) seedlings and T-DNA COPT1 insertion mutant (copt1) differ in their copper-transport activity. C1(OE) showed a fivefold higher Cu-induced K(+) efflux at the root tip compared with Col-0.

  4. overexpressing transgenic plants exhibit increased endogenous copper levels and are sensitive to the copper in the growth medium

Human Solute Carrier Family 31 (Copper Transporters), Member 1 (SLC31A1) interaction partners

  1. SLC31A1-dependent copper levels are correlated with the malignant degree of pancreatic cancer. Copper deprivation increased mitochondrial Reactive Oxygen Species level and decreased ATP level, which rendered cancer cells in a dormant state.

  2. combination of desferal with oxaliplatin can overcome cervical cancer oxaliplatin resistance through the regulation of hCtr1 and TfR1

  3. Study showed that NEAT1 could function as a competing endogenous lncRNA in lung cancer, mediating CTR1 by sponging hsa-mir-98-5p.

  4. This result indicates that the formation of copper-finger protein of Sp1 is the molecular basis of copper sensing for the transcriptional regulation of hCtr1 in mammalian cells.

  5. we assessed the role of miR-21 in mediating renal cell carcinoma chemoresistance and further showed that miR-21 silencing significantly (1) increased chemosensitivity of paclitaxel, 5-fluorouracil, oxaliplatin, and dovitinib; (2) decreased expression of multi-drug resistance genes; and (4) increased SLC22A1/OCT1, SLC22A2/OCT2, and SLC31A1/CTR1 platinum influx transporter expression

  6. Gene duplication and neo-functionalization in the evolutionary and functional divergence of the metazoan copper transporters Ctr1 and Ctr2

  7. It has been demonstrated in ovarian cancer cells that cisplatin resistance and uptake correlates with reduced CTR1 and LRRC8A protein expression/activity and a concomitant upregulation in cisplatin exporting transporters (ATP7A, ATP7B), which implies that the resistant cells have a reduced ability to accumulate cisplatin and activate proapoptotic transporters for osmolytes.

  8. CTR1 recycling via clathrin-mediated and Rab11 pathways enable cells to dynamically modulate copper entry

  9. C-Terminus of Human Copper Importer Ctr1 Acts as a Binding Site and Transfers Copper to Atox1

  10. Studied the interaction of CTR1 and CTR2 in fully malignant HEK293T and OVCAR8 human ovarian cancer cells using a CRISPR-Cas9 knock out system.

  11. High CTR1 Expression is associated with poor response to chemotherapy in Muscle-invasive Bladder Cancer.

  12. Gene silencing of either CTR1 or DMT1 did not affect copper accumulation in cells, but deficiency in both CTR1 and DMT1 resulted in a complete inhibition of copper uptake.

  13. Two methionine residues in the MXXXM motif of of the CTR1 second transmembrane domain are important for binding to silver.

  14. CTR1, ATP7A, and lysyl oxidase were upregulated in the lung tissues and pulmonary arteries of mice with hypoxia-induced pulmonary hypertension and pulmonary arterial smooth muscle cells.

  15. Data suggest that SLC31A1 and SLC31A2, despite being structurally closely related and sharing important amino acid motifs, play different roles in copper homeostasis and in platinum-based chemotherapy of neoplasms. [REVIEW]

  16. allele distribution of the SLC31A1 was not different between group N and O, and out of the 11 SNPs of the SLC22A2 gene only the allele distribution of the nonsynonymous SNP was significantly different between patients who experienced ototoxicity

  17. Extracellular copper concentrations regulate the levels of CTR1 through internalisation and degradation, the addition of prolactin, inhibits the degradation of CTR1, thus promoting copper uptake by mammary epithelial cells.

  18. NSC73306 is a transport substrate of CTR1

  19. The data collected here shows that the Atox1 keeps its dimer nature also in the presence of the CTR1 c-terminal domain; however, two geometrical states are assumed by the Atox1.

  20. CTR1 expression may be necessary for therapeutic efficacy of platinum based drugs in non-small cell lung cancer treatment.

Zebrafish Solute Carrier Family 31 (Copper Transporters), Member 1 (SLC31A1) interaction partners

  1. Studies show that zebrafish ctr1 is an essential gene for development.

Mouse (Murine) Solute Carrier Family 31 (Copper Transporters), Member 1 (SLC31A1) interaction partners

  1. Gene duplication and neo-functionalization in the evolutionary and functional divergence of the metazoan copper transporters Ctr1 and Ctr2

  2. studies identify a new processing event and the key protease that cleaves the Ctr1 metal-binding ectodomain, which functions to regulate cellular Cu(+) and cisplatin acquisition

  3. CTR1, ATP7A, and lysyl oxidase were upregulated in the lung tissues and pulmonary arteries of mice with hypoxia-induced pulmonary hypertension and pulmonary arterial smooth muscle cells.

  4. conclude that Y103 is required for the internalization of hCTR1 in response to Cu, that this occurs by a mechanism other than phosphorylation and that mutation of Y103 modulates the interaction with IRS-4

  5. A key regulatory mechanism for mammalian copper transport is through Ctr2-dependent accumulation of a Ctr1 variant lacking the copper- and cisplatin-binding ecto-domain.

  6. conclude that Cu acquired from CTR1 is required for signaling in pathways regulated by RTKs that play major roles in development and cance

  7. There was little difference in rates/kinetics of uptake of copper in the Ctr1+/+ and -/- cells. Endocytosis was not involved.

  8. basal expression of Ctr1 is regulated by HIF2alpha; however, the induction by hypoxia is a HIF2alpha-independent event

  9. Structure-functional organization of eukaryotic high-affinity copper importer CTR1 determines its ability to transport copper, silver and cisplatin

  10. Data show apical localization of Ctr1 in intestinal epithelia and suggest that increased Ctr1 apical localization in response to dietary copper limitation may represent an adaptive response to modulate Ctr1 availability at the site of copper absorption.

  11. Ctr1 is an important transport protein in the accumulation of silver in mammalian cells.

  12. Mouse cell lines lacking one or both mouse Ctr1 (mCtr1) alleles exhibit increased cisplatin resistance and decreased cisplatin accumulation in parallel with mCtr1 gene dosage

  13. These studies identify Ctr1 as the major factor driving intestinal Cu absorption in mammals.

  14. These studies support a model in which vertebrate Ctr1 functions as a key regulator of the differentiation capacity of both stem and progenitor cell populations.

  15. Deletion of hepatic Ctr1 reveals its function in copper acquisition and compensatory mechanisms for copper homeostasis.

  16. Ctr1 is mainly localized on the basolateral side of both proximal and distal tubular cells in mouse kidneys.

Solute Carrier Family 31 (Copper Transporters), Member 1 (SLC31A1) Protein Profile

Protein Summary

The protein encoded by this gene is a high-affinity copper transporter found in the cell membrane. The encoded protein functions as a homotrimer to effect the uptake of dietary copper.

Gene names and symbols associated with SLC31A1

  • solute carrier family 31 member 1 (SLC31A1)
  • copper transporter 1 (LOC100281410)
  • copper transporter 1 (LOC100286321)
  • solute carrier family 31 (copper transporter), member 1 (slc31a1)
  • copper transporter 1 (COPT1)
  • solute carrier family 31 member 1 (Slc31a1)
  • solute carrier family 31, member 1 (Slc31a1)
  • 4930445G01Rik protein
  • AI787263 protein
  • AU016967 protein
  • copper transporter 1 protein
  • COPT1 protein
  • ctr-1 protein
  • Ctr1 protein
  • hctr1 protein
  • K19M22.24 protein
  • LRRGT00200 protein
  • Slc31a1 protein
  • Xctr1 protein
  • zgc:76839 protein

Protein level used designations for SLC31A1

solute carrier family 31 (copper transporters), member 1 , high affinity copper uptake protein 1 , Copper transporter 1 , copper transporter 1 , solute carrier family 31 member 1 , copper transport 1 homolog , Copper uptake transporter 1 , liver regeneration-related protein LRRGT00200 , rCTR1 , high affinity copper uptake protein , solute carrier family 13 (sodium/sulphate symporters), member 1

GENE ID SPECIES
417268 Gallus gallus
464670 Pan troglodytes
481678 Canis lupus familiaris
518976 Bos taurus
706058 Macaca mulatta
100172583 Pongo abelii
100281410 Zea mays
100286321 Zea mays
407919 Xenopus (Silurana) tropicalis
836020 Arabidopsis thaliana
397186 Sus scrofa
1317 Homo sapiens
171135 Rattus norvegicus
403028 Danio rerio
20529 Mus musculus
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