anti-Sorbin and SH3 Domain Containing 2 (Sorbs2) Antibodies

Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. Additionally we are shipping Sorbs2 Proteins (4) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
Sorbs2 114901 O35413
Sorbs2 234214  
Sorbs2 8470 O94875
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Top anti-Sorbs2 Antibodies at antibodies-online.com

Showing 10 out of 35 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB Host: Rabbit Target Name: SORBS2 Sample Type: Fetal Kidney lysates Antibody Dilution: 1.0ug/ml 100 μL 2 to 3 Days
$319.00
Details
Human Rabbit Un-conjugated EIA, WB   0.4 mL 4 to 8 Days
$522.50
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human colon carcinoma labeled with Anti SORBS2 Polyclonal Antibody, Unconjugated (ABIN1387807) at 1:200 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded mouse tumor tissue labeled with Anti SORBS2 Polyclonal Antibody, Unconjugated (ABIN1387807) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL 3 to 7 Days
$317.90
Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB Fluorescent image of U251 cell stained with ARGBP2 Antibody (N-term).U251 cells were fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.1%, 10 min), then incubated with ARGBP2 primary antibody (1:25). For secondary antibody, Alexa Fluor 488 conjugated donkey anti-rabbit antibody (green) was used (1:400).Cytoplasmic actin was counterstained with Alexa Fluor 555 (red) conjugated Phalloidin (7units/ml).ARGBP2 immunoreactivity is localized to Nucleus significantly. Western blot analysis of ARGBP2 Antibody in MDA-MB231 cell line lysates (35ug/lane) 400 μL 2 to 3 Days
$515.63
Details
Human Mouse Un-conjugated IF, WB Western Blot analysis of SORBS2 expression in transfected 293T cell line by SORBS2 MaxPab polyclonal antibody.Lane 1: SORBS2 transfected lysate(121 KDa).Lane 2: Non-transfected lysate. Immunofluorescence of purified MaxPab antibody to SORBS2 on HepG2 cell. [antibody concentration 10 ug/ml] 50 μg 11 to 12 Days
$440.00
Details
Human Rabbit Cy3 IF (p)   100 μL 14 to 21 Days
$416.90
Details
Human Rabbit Cy5.5 IF (p)   100 μL 14 to 21 Days
$416.90
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Human Rabbit Cy5 IF (p)   100 μL 14 to 21 Days
$416.90
Details
Human Rabbit Cy7 IF (p)   100 μL 14 to 21 Days
$416.90
Details
Human Rabbit HRP IHC (p), WB   100 μL 14 to 21 Days
$416.90
Details

Top referenced anti-Sorbs2 Antibodies

  1. Human Polyclonal Sorbs2 Primary Antibody for IF, WB - ABIN521930 : Lamberti, Sanges, Chambery, Migliaccio, Rosso, Di Maro, Papale, Marra, Parente, Caraglia, Abbruzzese, Arcari: Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics. in Biochimie 2011 (PubMed)

More Antibodies against Sorbs2 Interaction Partners

Mouse (Murine) Sorbin and SH3 Domain Containing 2 (Sorbs2) interaction partners

  1. the present study provides strong evidence that miR-21-3p controls sepsis-associated cardiac dysfunction via regulating SORBS2. Inhibition of miR-21-3p might be a protective strategy to treat sepsis-induced cardiac dysfunction.

  2. The nArgBP2 binds to the two most prominent postsynaptic proteins that are associated with various mood disorders, we propose that nArgBP2could function as a hub able to link together etiological factors of different disorders.

  3. The study screened CrkL binding proteins using RNA interference (RNAi) and identified Sorbs1 and Sorbs2 as two proteins that are enriched at AChR clusters and are required for the formation of AChR aggregation in vitro.

Human Sorbin and SH3 Domain Containing 2 (Sorbs2) interaction partners

  1. By enhancing the stability of gene transcripts, SORBS2 suppresses ovarian cancer invasiveness and affects monocyte to myeloid-derived suppressor cell and M2-like macrophage polarization, eliciting a tumor-suppressive immune microenvironment.

  2. results thus contribute to the knowledge of the regulatory mechanism of HSF1 in down-regulating ArgBP2, providing new insight into the HSF1&MORC2-PRC2-ArgBP2 signaling pathway and a better understanding of their functions in gastric cancer cells.

  3. In spite of our finding that SORBS2 is clearly a component of the apical junction complex, it does not appear to be required for either normal tight- or adherens junction assembly, structure or function or for growth factor-mediated changes in tight junction dynamics

  4. SORBS2 transcription is activated by telomere position effect-over long distance upon telomere shortening in muscle cells from patients with facioscapulohumeral dystrophy

  5. ArgBP2 inhibits proliferation, migration, and invasion of gastric cancer cells.MORC2 down-regulates the ArgBP2 via histone methylation in gastric cancer cells.

  6. This study confirmed that SORBS2 as genetic modifiers of age at onset of Alzheimer disease.

  7. ArgBP2 interaction with alpha-actinin and actin stress fibers inhibits cell migration

  8. Tyrosine phosphorylation of ARGBP2 interferes with a SH3 mediated self-interaction, thereby controlling its panel of interacting partners and related functions.

  9. SORBS2 and TLR3 induce premature senescence in primary human fibroblasts and keratinocytes.

  10. Sarcoplasmic sorbin and SH3 domain-containing protein 2 is released from damaged cardiac tissue into the bloodstream upon lethal acute myocardial infarction.

  11. the expression and localization of hArgBP2 in osteosarcoma MG-63 cells

  12. In epithelial NMuMG cells, immunofluorescence analyses revealed localization of ArgBP2 at tight junctions and mutation analyses found a second SH3 domain to be important for ArgBP2 localization to the cell-cell contact sites.

  13. A co-localization of SORBS2 and eEF1A was evidenced at level of plasma membrane, thus suggesting the involvement of eEF1A1 in novel key signal transduction complexes.

  14. Reconstitution of SORBS2 expression resulted significant reduction in cell proliferation, colony formation and anchorage-independent growth in CaSki, HPKII and HaCaT cells, whereby anchorage-independent growth could only be investigated for CaSki cells

  15. Results indicate that ArgBP2 may play an important role in the assembly and maintenance of myofibrils in cardiomyocytes.

  16. CIP4 is a new ArgBP2 interacting protein that modulates the ArgBP2 mediated control of WAVE1 phosphorylation and cancer cell migration.

  17. complexation with Cbl mediates ubiquitination and degradation of c-Abl

  18. regulates cytoskeletal organization and signal transduction--review

  19. The sorbin N- and C-termini were localized in the human ArgBP2 gene locus; they are spliced to the 5' and 3' ends of the 95% homologous region; thus, a revised human sorbin nucleotide sequence is proposed.

  20. Loss of ArgBP2 is associated with pancreatic cancer.

Sorbs2 Antigen Profile

Protein Summary

Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins. This gene encodes the sorbin and SH3 domain containing 2 protein. It has three C-terminal SH3 domains and an N-terminal sorbin homology (SoHo) domain that interacts with lipid raft proteins. The subcellular localization of this protein in epithelial and cardiac muscle cells suggests that it functions as an adapter protein to assemble signaling complexes in stress fibers, and that it is a potential link between Abl family kinases and the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with Sorbs2

  • sorbin and SH3 domain containing 2 (Sorbs2) antibody
  • sorbin and SH3 domain containing 2 (SORBS2) antibody
  • sorbin and SH3 domain containing 2 (sorbs2) antibody
  • 2010203O03Rik antibody
  • 9430041O17RIK antibody
  • A530071H08 antibody
  • ARGBP2 antibody
  • DKFZp468F1119 antibody
  • mKIAA0777 antibody
  • PRO0618 antibody

Protein level used designations for Sorbs2

Arg/Abl-interacting protein ArgBP2 , arg/Abl-interacting protein 2 , nArgBP2 , neural ArgBP2 , sorbin and SH3 domain-containing protein 2 , Arg/Abl-interacting protein 2 , sorbin and SH3 domain containing 2 , sorbin and SH3 domain-containing protein 2-like , Arg binding protein 2 , Sorbin and SH3 domain-containing protein 2 , sorbin polypeptide

GENE ID SPECIES
114901 Rattus norvegicus
234214 Mus musculus
614391 Bos taurus
100196922 Xenopus (Silurana) tropicalis
422719 Gallus gallus
461640 Pan troglodytes
482906 Canis lupus familiaris
696139 Macaca mulatta
100014403 Monodelphis domestica
100050682 Equus caballus
100172173 Pongo abelii
100231821 Taeniopygia guttata
100344295 Oryctolagus cuniculus
100413518 Callithrix jacchus
100469106 Ailuropoda melanoleuca
8470 Homo sapiens
396719 Sus scrofa
100724374 Cavia porcellus
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