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SORCS2 encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. Additionally we are shipping SORCS2 Proteins (5) and SORCS2 Kits (3) and many more products for this protein.
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Here the authors have characterized SorCS1 (show SORCS1 Antibodies), SorCS2 and SorCS3 (show SORCS3 Antibodies) using biochemical methods and electron microscopy. They found that their purified extracellular domains co-exist in stable dimeric and monomeric populations.
Sortilin-related receptor (show SORL1 Antibodies) CNS expressed 2 (SorCS2) is one of the vacuolar protein sorting 10 family proteins which may be involved in the disease process of amyotrophic lateral sclerosis
Results indicate that hearing loss and hair bundle defects are associated with SorCS2 (Sortilin (show SORT1 Antibodies)-related VPS-10 domain containing protein) disruption.
SorCS2 is expressed in mesodermally derived tissues such as striated (show NSDHL Antibodies) muscle, adipose tissue, ossifying bone and connective tissue.
SorCS3 (show SORCS3 Antibodies) and the homologous sorCS1 (show SORCS1 Antibodies) and sorCS2 genes were expressed in a combinatorial mostly non-overlapping pattern in the developing and mature central nervous system; activity-dependent induction of sorCS3 (show SORCS3 Antibodies) did not require protein synthesis
This gene encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. The VPS10 domain name comes from the yeast carboxypeptidase Y sorting receptor Vps10 protein. Members of this gene family are large with many exons but the CDS lengths are usually less than 3700 nt. Very large introns typically separate the exons encoding the VPS10 domain\; the remaining exons are separated by much smaller-sized introns. These genes are strongly expressed in the central nervous system.
sortilin-related VPS10 domain containing receptor 2
, VPS10 domain receptor protein SORCS 2
, VPS10 domain-containing receptor SorCS2-like
, VPS10 domain receptor protein
, VPS10 domain-containing receptor SorCS2