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SNX27 encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. Additionally we are shipping SNX27 Antibodies (82) and and many more products for this protein.
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Biochemistry and microscopy approaches in T cells confirmed SNX27/ZO-2 (show TJP2 Proteins) PDZ-dependent interaction, and demonstrated its role controlling the dynamic localization of ZO-2 (show TJP2 Proteins) at the IS
Results show a crucial role of SNX27 in modulating GPR17 (show GPR17 Proteins) levels by means of a post-translational mechanism and highlights the relationship between the trafficking of the receptor through the endomembrane system and oligodendrocyte differentiation; and provide novel evidence of impairment of GPR17 (show GPR17 Proteins) expression and oligodendrocyte maturation in a mouse model of Down syndrome that is characterized by SNX27 down-regulation.
The viral oncoprotein E6 interaction with SNX27 can alter the recycling of cargo molecules, one consequence of which is modulation of nutrient availability in HPV transformed tumour cells.
This study defines specific acidic amino acid sequences upstream of the PDZ-binding motif required for high-affinity engagement of the human SNX27 PDZ domain.
a function of SNX27 in regulating beta-amyloid (Abeta (show APP Proteins)) generation by modulating gamma-secretase activity.
PTHR recycles rapidly through at least two pathways, one involving the ASRT complex of actin, SNX27, and retromer and another possibly involving N-ethylmaleimide-sensitive factor (show NSF Proteins).
SNX27 inhibits the Wnt regulated transcription activity of TCF/LEF. Our results suggested that SNX27 interacts with Frizzled receptors to regulate the endocytosis and stability of Fzds
SNX27 interaction with FAM21 is required for the precise localization of SNX27 at an endosomal subdomain.
SNX27 deficiency is now added to the growing list of neurodegenerative disorders associated with retromer dysfunction.
The results suggest that SNX27 undergoes dynamic partitioning between different membrane domains during immunological synapse assembly, and underscore the contribution of unique lipid interactions for SNX27 orchestration of cargo trafficking.
we anticipate that future study will determine whether modulation of a SNX27/Notch (show NOTCH1 Proteins)/gamma-secretase pathway can also be of therapeutic interest to congenital hydrocephalus (show FOXC1 Proteins)
We identify binding and trafficking interactions between two of these factors, SORLA (show SORL1 Proteins) and SNX27, and demonstrate that SNX27 can direct trafficking of SORLA (show SORL1 Proteins) and the Abeta (show APP Proteins) precursor APP (show APP Proteins) to the cell surface to limit the production of Abeta (show APP Proteins). Diversion APP (show APP Proteins) to the cell surface through modulation of this molecular complex may represent a complimentary strategy for future development in AD treatment.
A critical role for SNX27-retromer mediated transport of PTHR (show PTH1R Proteins) in normal bone development.
VPS26A binding increases the affinity of the SNX27 PDZ domain for PDZ- binding motifs by an order of magnitude, revealing cooperativity in cargo selection.
SNX27-dependent mechanism of inhibitory plasticity in DA neurons is a potential intervention point for disorders of dopamine neurons.
SNX27 associates with ZO-2 (show TJP2 Proteins) and modulates the epithelial tight junction.
a model by which SNX27 regulates trafficking of beta-Pix (show ARHGEF7 Proteins) to focal adhesions and thereby influences cell motility.
indicate that SNX27 may function to regulate endocytosis and/or endosomal sorting of NR2C (show GRIN2C Proteins)
This gene encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. All members of this protein family contain a phosphoinositide binding domain (PX domain). A highly similar protein in mouse is responsible for the specific recruitment of an isoform of serotonin 5-hydroxytryptamine 4 receptor into early endosomes, suggesting the analogous role for the human protein.
methamphetamine-responsive transcript 1
, sorting nexin-27
, MAP-responsive gene protein
, PDZ protein Mrt1
, PDZ-protein Mrt1
, methamphetamine (MAP) responsive transcript 1
, methamphetamine-responsive transcript 1 protein