Sorting Nexin 27 Proteins (SNX27)

SNX27 encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. Additionally we are shipping SNX27 Antibodies (82) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SNX27 81609 Q96L92
SNX27 76742 Q3UHD6
SNX27 260323 Q8K4V4
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top SNX27 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,797.11
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,797.11
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$547.80
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,540.17
Details

SNX27 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Sorting Nexin 27 (SNX27) Interaction Partners

Human Sorting Nexin 27 (SNX27) interaction partners

  1. Biochemistry and microscopy approaches in T cells confirmed SNX27/ZO-2 (show TJP2 Proteins) PDZ-dependent interaction, and demonstrated its role controlling the dynamic localization of ZO-2 (show TJP2 Proteins) at the IS

  2. Results show a crucial role of SNX27 in modulating GPR17 (show GPR17 Proteins) levels by means of a post-translational mechanism and highlights the relationship between the trafficking of the receptor through the endomembrane system and oligodendrocyte differentiation; and provide novel evidence of impairment of GPR17 (show GPR17 Proteins) expression and oligodendrocyte maturation in a mouse model of Down syndrome that is characterized by SNX27 down-regulation.

  3. The viral oncoprotein E6 interaction with SNX27 can alter the recycling of cargo molecules, one consequence of which is modulation of nutrient availability in HPV transformed tumour cells.

  4. This study defines specific acidic amino acid sequences upstream of the PDZ-binding motif required for high-affinity engagement of the human SNX27 PDZ domain.

  5. a function of SNX27 in regulating beta-amyloid (Abeta (show APP Proteins)) generation by modulating gamma-secretase activity.

  6. PTHR recycles rapidly through at least two pathways, one involving the ASRT complex of actin, SNX27, and retromer and another possibly involving N-ethylmaleimide-sensitive factor (show NSF Proteins).

  7. SNX27 inhibits the Wnt regulated transcription activity of TCF/LEF. Our results suggested that SNX27 interacts with Frizzled receptors to regulate the endocytosis and stability of Fzds

  8. SNX27 interaction with FAM21 is required for the precise localization of SNX27 at an endosomal subdomain.

  9. SNX27 deficiency is now added to the growing list of neurodegenerative disorders associated with retromer dysfunction.

  10. The results suggest that SNX27 undergoes dynamic partitioning between different membrane domains during immunological synapse assembly, and underscore the contribution of unique lipid interactions for SNX27 orchestration of cargo trafficking.

Mouse (Murine) Sorting Nexin 27 (SNX27) interaction partners

  1. Results show a crucial role of SNX27 in modulating GPR17 (show GPR17 Proteins) levels by means of a post-translational mechanism and highlights the relationship between the trafficking of the receptor through the endomembrane system and oligodendrocyte differentiation; and provide novel evidence of impairment of GPR17 (show GPR17 Proteins) expression and oligodendrocyte maturation in a mouse model of Down syndrome that is characterized by SNX27 down-regulation.

  2. we anticipate that future study will determine whether modulation of a SNX27/Notch (show NOTCH1 Proteins)/gamma-secretase pathway can also be of therapeutic interest to congenital hydrocephalus (show FOXC1 Proteins)

  3. We identify binding and trafficking interactions between two of these factors, SORLA (show SORL1 Proteins) and SNX27, and demonstrate that SNX27 can direct trafficking of SORLA (show SORL1 Proteins) and the Abeta (show APP Proteins) precursor APP (show APP Proteins) to the cell surface to limit the production of Abeta (show APP Proteins). Diversion APP (show APP Proteins) to the cell surface through modulation of this molecular complex may represent a complimentary strategy for future development in AD treatment.

  4. A critical role for SNX27-retromer mediated transport of PTHR (show PTH1R Proteins) in normal bone development.

  5. a function of SNX27 in regulating beta-amyloid (Abeta (show APP Proteins)) generation by modulating gamma-secretase activity.

  6. VPS26A binding increases the affinity of the SNX27 PDZ domain for PDZ- binding motifs by an order of magnitude, revealing cooperativity in cargo selection.

  7. SNX27-dependent mechanism of inhibitory plasticity in DA neurons is a potential intervention point for disorders of dopamine neurons.

  8. SNX27 associates with ZO-2 (show TJP2 Proteins) and modulates the epithelial tight junction.

  9. a model by which SNX27 regulates trafficking of beta-Pix (show ARHGEF7 Proteins) to focal adhesions and thereby influences cell motility.

  10. indicate that SNX27 may function to regulate endocytosis and/or endosomal sorting of NR2C (show GRIN2C Proteins)

SNX27 Protein Profile

Protein Summary

This gene encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. All members of this protein family contain a phosphoinositide binding domain (PX domain). A highly similar protein in mouse is responsible for the specific recruitment of an isoform of serotonin 5-hydroxytryptamine 4 receptor into early endosomes, suggesting the analogous role for the human protein.

Gene names and symbols associated with Sorting Nexin 27 Proteins (SNX27)

  • sorting nexin family member 27 (SNX27)
  • sorting nexin family member 27 (Snx27)
  • 5730552M22Rik protein
  • ESTM45 protein
  • ESTM47 protein
  • mKIAA0488 protein
  • Mrt1 protein
  • MY014 protein
  • R75405 protein

Protein level used designations for Sorting Nexin 27 Proteins (SNX27)

methamphetamine-responsive transcript 1 , sorting nexin-27 , MAP-responsive gene protein , PDZ protein Mrt1 , PDZ-protein Mrt1 , methamphetamine (MAP) responsive transcript 1 , methamphetamine-responsive transcript 1 protein

GENE ID SPECIES
81609 Homo sapiens
76742 Mus musculus
260323 Rattus norvegicus
513214 Bos taurus
425666 Gallus gallus
483200 Canis lupus familiaris
Selected quality suppliers for SNX27 Proteins (SNX27)
Did you look for something else?