Sorting Nexin 27 Proteins (SNX27)

SNX27 encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. Additionally we are shipping SNX27 Antibodies (93) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SNX27 81609 Q96L92
SNX27 76742 Q3UHD6
SNX27 260323 Q8K4V4
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Top SNX27 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,626.73
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,626.73
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days
$888.80
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,540.17
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SNX27 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Sorting Nexin 27 (SNX27) Interaction Partners

Human Sorting Nexin 27 (SNX27) interaction partners

  1. data reveal a role for SNX27 in glutamine uptake and amino acid-stimulated mTORC1 activation via modulation of ASCT2 intracellular trafficking

  2. Biochemistry and microscopy approaches in T cells confirmed SNX27/ZO-2 PDZ-dependent interaction, and demonstrated its role controlling the dynamic localization of ZO-2 at the IS

  3. Results show a crucial role of SNX27 in modulating GPR17 levels by means of a post-translational mechanism and highlights the relationship between the trafficking of the receptor through the endomembrane system and oligodendrocyte differentiation; and provide novel evidence of impairment of GPR17 expression and oligodendrocyte maturation in a mouse model of Down syndrome that is characterized by SNX27 down-regulation.

  4. The viral oncoprotein E6 interaction with SNX27 can alter the recycling of cargo molecules, one consequence of which is modulation of nutrient availability in HPV transformed tumour cells.

  5. This study defines specific acidic amino acid sequences upstream of the PDZ-binding motif required for high-affinity engagement of the human SNX27 PDZ domain.

  6. a function of SNX27 in regulating beta-amyloid (Abeta) generation by modulating gamma-secretase activity.

  7. PTHR recycles rapidly through at least two pathways, one involving the ASRT complex of actin, SNX27, and retromer and another possibly involving N-ethylmaleimide-sensitive factor.

  8. SNX27 inhibits the Wnt regulated transcription activity of TCF/LEF. Our results suggested that SNX27 interacts with Frizzled receptors to regulate the endocytosis and stability of Fzds

  9. SNX27 interaction with FAM21 is required for the precise localization of SNX27 at an endosomal subdomain.

  10. SNX27 deficiency is now added to the growing list of neurodegenerative disorders associated with retromer dysfunction.

  11. The results suggest that SNX27 undergoes dynamic partitioning between different membrane domains during immunological synapse assembly, and underscore the contribution of unique lipid interactions for SNX27 orchestration of cargo trafficking.

  12. The double knockdown of SNX17 and SNX27 results in a striking reduction of papillomavirus 16 infection due to interruption of their binding to the L2 viral protein.

  13. RNAi-mediated suppression of ANKRD50 phenocopies loss of SNX27-retromer function.

  14. VPS26A binding increases the affinity of the SNX27 PDZ domain for PDZ- binding motifs by an order of magnitude, revealing cooperativity in cargo selection.

  15. Ras-association domain of sorting Nexin 27 is critical for regulating expression of GIRK potassium channels.

  16. Direct interaction of the SNX27 PDZ domain with the retromer subunit VPS26 is necessary and sufficient to prevent lysosomal entry of SNX27 cargo.

  17. SNX27 interacts with MRP4 near the plasma membrane and promotes endocytosis of MRP4 and thereby negatively regulates its cell surface expression and transport function.

  18. a model by which SNX27 regulates trafficking of beta-Pix to focal adhesions and thereby influences cell motility.

  19. show that sorting nexin 27 (SNX27) serves as an essential adaptor protein linking beta2ARs to the retromer tubule

  20. These results identify SNX27 as a PDZ-containing component of the T cell immunological synapse, and demonstrate a role for this protein in the regulation of the Ras-ERK pathway, suggesting a functional relationship between SNX27 and DGKzeta.

Mouse (Murine) Sorting Nexin 27 (SNX27) interaction partners

  1. Results show a crucial role of SNX27 in modulating GPR17 levels by means of a post-translational mechanism and highlights the relationship between the trafficking of the receptor through the endomembrane system and oligodendrocyte differentiation; and provide novel evidence of impairment of GPR17 expression and oligodendrocyte maturation in a mouse model of Down syndrome that is characterized by SNX27 down-regulation.

  2. we anticipate that future study will determine whether modulation of a SNX27/Notch/gamma-secretase pathway can also be of therapeutic interest to congenital hydrocephalus

  3. We identify binding and trafficking interactions between two of these factors, SORLA and SNX27, and demonstrate that SNX27 can direct trafficking of SORLA and the Abeta precursor APP to the cell surface to limit the production of Abeta. Diversion APP to the cell surface through modulation of this molecular complex may represent a complimentary strategy for future development in AD treatment.

  4. A critical role for SNX27-retromer mediated transport of PTHR in normal bone development.

  5. a function of SNX27 in regulating beta-amyloid (Abeta) generation by modulating gamma-secretase activity.

  6. VPS26A binding increases the affinity of the SNX27 PDZ domain for PDZ- binding motifs by an order of magnitude, revealing cooperativity in cargo selection.

  7. SNX27-dependent mechanism of inhibitory plasticity in DA neurons is a potential intervention point for disorders of dopamine neurons.

  8. beta1-adrenergic receptor recycles via a membranous organelle, recycling endosome, by binding with sorting nexin27.

  9. SNX27 associates with ZO-2 and modulates the epithelial tight junction.

  10. a model by which SNX27 regulates trafficking of beta-Pix to focal adhesions and thereby influences cell motility.

  11. indicate that SNX27 may function to regulate endocytosis and/or endosomal sorting of NR2C

  12. SNX27 and NHERF specifically interact with the 5-HT4a receptor splice variant

  13. These data support a previously unreported role for diacylglycerol kinase zeta in the modulation of membrane trafficking, which may also help to define SNX27 function.

  14. This study shows that SNX27 promotes the endosomal movement of Kir3 (or GIRK) channels, leading to reduced surface expression, increased degradation and smaller Kir3 potassium currents.

SNX27 Protein Profile

Protein Summary

This gene encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. All members of this protein family contain a phosphoinositide binding domain (PX domain). A highly similar protein in mouse is responsible for the specific recruitment of an isoform of serotonin 5-hydroxytryptamine 4 receptor into early endosomes, suggesting the analogous role for the human protein.

Gene names and symbols associated with Sorting Nexin 27 Proteins (SNX27)

  • sorting nexin family member 27 (SNX27)
  • sorting nexin family member 27 (Snx27)
  • 5730552M22Rik protein
  • ESTM45 protein
  • ESTM47 protein
  • mKIAA0488 protein
  • Mrt1 protein
  • MY014 protein
  • R75405 protein

Protein level used designations for Sorting Nexin 27 Proteins (SNX27)

methamphetamine-responsive transcript 1 , sorting nexin-27 , MAP-responsive gene protein , PDZ protein Mrt1 , PDZ-protein Mrt1 , methamphetamine (MAP) responsive transcript 1 , methamphetamine-responsive transcript 1 protein

GENE ID SPECIES
81609 Homo sapiens
76742 Mus musculus
260323 Rattus norvegicus
513214 Bos taurus
425666 Gallus gallus
483200 Canis lupus familiaris
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