anti-Sparc/osteonectin, Cwcv and Kazal-Like Domains Proteoglycan (Testican) 1 (SPOCK1) Antibodies

SPOCK1 encodes the protein core of a seminal plasma proteoglycan containing chondroitin- and heparan-sulfate chains. Additionally we are shipping SPOCK1 Proteins (8) and SPOCK1 Kits (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SPOCK1 6695 Q08629
SPOCK1 306759  
SPOCK1 20745  
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Top anti-SPOCK1 Antibodies at antibodies-online.com

Showing 10 out of 33 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB SPOCK1 Antibody (N-term) (ABIN1881825) western blot analysis in MDA-MB453 cell line lysates (35 µg/lane). This demonstrates the SPOCK1 antibody detected the SPOCK1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated IHC, IHC (p) Immunohistochemistry-Paraffin: Testican 1/SPOCK1 Antibody  - Staining of human prostate shows cytoplasmic positivity in glandular cells. 0.1 mL Log in to see 7 to 9 Days
$494.38
Details
Human Mouse Un-conjugated WB Western Blot analysis of SPOCK1 expression in transfected 293T cell line by SPOCK1 MaxPab polyclonal antibody.Lane 1: SPOCK1 transfected lysate(48.29 KDa).Lane 2: Non-transfected lysate. 50 μL Log in to see 11 to 12 Days
$440.00
Details
Human Rabbit Un-conjugated ELISA, WB   100 μL Log in to see 16 Days
$293.00
Details
Human Rabbit Biotin ELISA, WB   200 μL Log in to see 11 to 14 Days
$1,013.83
Details
Human Rabbit Un-conjugated WB   400 μL Log in to see 11 to 14 Days
$463.83
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB U251 lysates probed with SPOCK1 Polyclonal Antibody, Unconjugated  at 1:500 dilution and 4˚C overnight incubation. Followed by conjugated secondary antibody incubation at 1:10000 for 60 min at 37˚C. 100 μL Log in to see 3 to 7 Days
$317.90
Details
Human Rabbit Un-conjugated IHC, WB   100 μL Log in to see 7 to 8 Days
$454.67
Details
Human Rabbit Biotin ELISA, WB   200 μL Log in to see 16 Days
$743.29
Details
Human Rabbit FITC ELISA   100 μg Log in to see 11 to 16 Days
$412.19
Details

Top referenced anti-SPOCK1 Antibodies

  1. Human Polyclonal SPOCK1 Primary Antibody for WB - ABIN1881825 : Nakada, Miyamori, Yamashita, Sato: Testican 2 abrogates inhibition of membrane-type matrix metalloproteinases by other testican family proteins. in Cancer research 2003 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal SPOCK1 Primary Antibody for IHC, IHC (p) - ABIN4358527 : Damhofer, Medema, Veenstra, Badea, Popescu, Roelink, Bijlsma: Assessment of the stromal contribution to Sonic Hedgehog-dependent pancreatic adenocarcinoma. in Molecular oncology 2013 (PubMed)

More Antibodies against SPOCK1 Interaction Partners

Human Sparc/osteonectin, Cwcv and Kazal-Like Domains Proteoglycan (Testican) 1 (SPOCK1) interaction partners

  1. Testican-1 blood level is related to the severity of sepsis and Testican-1 could be used as a biomarker to determine the severity of sepsis.

  2. Overexpression of SPOCK1was confirmed in head and neck squamous cell carcinoma clinical specimens. Overexpression of SPOCK1 contributes to the aggressive nature of HNSCC.

  3. High SPOCK1 expression is associated with castration-resistant prostate cancer.

  4. downregulation of both strands of pre-miR-150 and overexpression of SPOCK1 are involved in esophageal squamous cell carcinoma (ESCC). pathogenesis. The involvement of passenger strand miRNAs in the regulation of cancer cell aggressiveness is a novel concept in RNA research

  5. is significantly upregulated in osteosarcoma tissue.

  6. Functional assessment in cocultures demonstrated that SPOCK1 strongly affects the composition of the extracellular collagen matrix and by doing so, enables invasive tumor cell growth in Pancreatic ductal adenocarcinoma.

  7. Transcriptomic analysis of EPCR-silenced tumors unveiled an effect mediated by matricellular SPOCK1/testican 1. SPOCK1 silencing suppressed in vitro 3D growth. SPOCK1 ablation decreased orthotopic tumor growth and reduced metastatic osteolytic tumors. High SPOCK1 levels were also associated with poor clinical outcome in a subset of breast cancer patients.

  8. a novel TGF-beta-induced myoepithelial marker and enhanced invasion in breast cancer cells and correlated with poor prognosis

  9. Our results suggested that microRNA-129-5p could directly specifically suppress SPOCK1, which might be one of the potential mechanisms in inhibiting cell processes including viability, proliferation, cell mitosis, migration, and invasiveness of gastric cancer cells.

  10. SPOCK1 expression is significantly up-regulated in colorectal cancer tissues and associated with tumor size and stage. SPOCK1 stimulates the PI3K/AKT signaling pathway to inhibit cell apoptosis and promote tumor growth.

  11. findings suggest that SPOCK1 is a critical mediator of tumor growth and metastasis in prostate cancer

  12. Knockdown of SPOCK1 inhibits the proliferation.

  13. This study suggests that SPOCK1 promotes proliferation, migration and invasion in glioma cells by activating PI3K/AKT and Wnt/beta-catenin pathways, which provides a potential theoretical basis for clinical treatment of glioma.

  14. SPOCK1 is highly expressed in ovarian cancer.SPOCK1 contributes to ovarian cancer development and metastasis.

  15. These results suggest that up-regulation of SPOCK1 in ESCC induces EMT, thus promotes migration and invasion in ESCC cells.

  16. Collectively, altered expression of PKP1 and SPOCK1 appears to be a frequent and critical event in prostate cancer

  17. SPOCK1 activates PI3K/Akt signaling.

  18. Testican-1-induced EMT signaling.

  19. this study showed that SPOCK1 is a novel metastasis related biomarker in lung cancer and may be new diagnostic and therapeutic target for lung cancer.

  20. In the present study, we showed that SPOCK1 could inhibit apoptosis and promote cancer invasion.

Mouse (Murine) Sparc/osteonectin, Cwcv and Kazal-Like Domains Proteoglycan (Testican) 1 (SPOCK1) interaction partners

  1. Testican-1 blood level is related to the severity of sepsis and Testican-1 could be used as a biomarker to determine the severity of sepsis.

  2. results suggest a possibility that testican-1 plays a permissive role for regenerating axons in reactive astrocytes after injury

  3. limits the accumulation of adipose tissue in mice in part through its demonstrated effects on the regulation of cell shape and production of extracellular matrix

  4. SPARC is counter-adhesive for murine lens epithelial cells. We also identify SPARC as a modulator of LN-1 secretion and deposition, an activity important in epithelial cell-ECM interactions in the ocular lens.

  5. Testican-1 is not critical for mouse development [review]

SPOCK1 Antigen Profile

Protein Summary

This gene encodes the protein core of a seminal plasma proteoglycan containing chondroitin- and heparan-sulfate chains. The protein's function is unknown, although similarity to thyropin-type cysteine protease-inhibitors suggests its function may be related to protease inhibition.

Gene names and symbols associated with SPOCK1

  • SPARC/osteonectin, cwcv and kazal like domains proteoglycan 1 (SPOCK1) antibody
  • sparc/osteonectin, cwcv and kazal like domains proteoglycan 1 (Spock1) antibody
  • sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1 (Spock1) antibody
  • Spock antibody
  • testican antibody
  • TIC1 antibody
  • Ticn1 antibody

Protein level used designations for SPOCK1

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 , sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1 , testican-1 , testican-1-like , testican 1

GENE ID SPECIES
416304 Gallus gallus
462085 Pan troglodytes
511211 Bos taurus
715989 Macaca mulatta
100223935 Taeniopygia guttata
100398533 Callithrix jacchus
100443494 Pongo abelii
100478104 Ailuropoda melanoleuca
100542336 Meleagris gallopavo
100583164 Nomascus leucogenys
6695 Homo sapiens
474688 Canis lupus familiaris
100620623 Sus scrofa
306759 Rattus norvegicus
20745 Mus musculus
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