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SPOCK1 encodes the protein core of a seminal plasma proteoglycan containing chondroitin- and heparan-sulfate chains. Additionally we are shipping SPOCK1 Proteins (8) and SPOCK1 Kits (6) and many more products for this protein.
Showing 10 out of 31 products:
Human Polyclonal SPOCK1 Primary Antibody for IHC, IHC (p) - ABIN4358527
Damhofer, Medema, Veenstra, Badea, Popescu, Roelink, Bijlsma: Assessment of the stromal contribution to Sonic Hedgehog-dependent pancreatic adenocarcinoma. in Molecular oncology 2013
High SPOCK1 expression is associated with castration-resistant prostate cancer.
downregulation of both strands of pre-miR (show MLXIP Antibodies)-150 and overexpression of SPOCK1 are involved in esophageal squamous cell carcinoma (ESCC). pathogenesis. The involvement of passenger strand miRNAs in the regulation of cancer cell aggressiveness is a novel concept in RNA research
Functional assessment in cocultures demonstrated that SPOCK1 strongly affects the composition of the extracellular collagen matrix and by doing so, enables invasive tumor cell growth in Pancreatic ductal adenocarcinoma.
Transcriptomic analysis of EPCR (show PROCR Antibodies)-silenced tumors unveiled an effect mediated by matricellular SPOCK1/testican 1. SPOCK1 silencing suppressed in vitro 3D growth. SPOCK1 ablation decreased orthotopic tumor growth and reduced metastatic osteolytic tumors. High SPOCK1 levels were also associated with poor clinical outcome in a subset of breast cancer patients.
a novel TGF-beta (show TGFB1 Antibodies)-induced myoepithelial marker and enhanced invasion in breast cancer cells and correlated with poor prognosis
Our results suggested that microRNA-129-5p could directly specifically suppress SPOCK1, which might be one of the potential mechanisms in inhibiting cell processes including viability, proliferation, cell mitosis, migration, and invasiveness of gastric cancer cells.
SPOCK1 expression is significantly up-regulated in colorectal cancer tissues and associated with tumor size and stage. SPOCK1 stimulates the PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) signaling pathway to inhibit cell apoptosis and promote tumor growth.
findings suggest that SPOCK1 is a critical mediator of tumor growth and metastasis in prostate cancer
Knockdown of SPOCK1 inhibits the proliferation.
This study suggests that SPOCK1 promotes proliferation, migration and invasion in glioma cells by activating PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) and Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) pathways, which provides a potential theoretical basis for clinical treatment of glioma.
results suggest a possibility that testican-1 plays a permissive role for regenerating axons in reactive astrocytes after injury
SPARC (show SPARC Antibodies) is counter-adhesive for murine lens epithelial cells. We also identify SPARC (show SPARC Antibodies) as a modulator of LN-1 (show PHYH Antibodies) secretion and deposition, an activity important in epithelial cell-ECM (show MMRN1 Antibodies) interactions in the ocular lens.
Testican-1 is not critical for mouse development [review]
This gene encodes the protein core of a seminal plasma proteoglycan containing chondroitin- and heparan-sulfate chains. The protein's function is unknown, although similarity to thyropin-type cysteine protease-inhibitors suggests its function may be related to protease inhibition.
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
, sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1
, testican 1