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The protein encoded by SMPD1 is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. Additionally we are shipping Sphingomyelin phosphodiesterase 1, Acid Lysosomal Antibodies (76) and Sphingomyelin phosphodiesterase 1, Acid Lysosomal Kits (36) and many more products for this protein.
Showing 9 out of 12 products:
the human ASM holoenzyme and product bound structures encompassing all of the functional domains, are presented.
This study sheds light on the molecular mechanism of ASMase function.
The results suggest an association of Acid sphingomyelinase activation with Respiratory Syncytial Virus infection, a cause for common acute illness.
This study identified association between Leu-Ala (Val) repeat variants in SMPD1 and Chinese Han patients with sporadic Parkinson's disease.
Parkinson's disease is associated with mutations in SMPD1 gene in Ashkenazi Jews.
Through genetic analysis it was determined that genetic variants in SMPD1 increase the risk of Parkinson's Disease in the Chinese Han population.
Enzyme activities (acid alpha-glucosidase (GAA), galactocerebrosidase (GALC (show GALC Proteins)), glucocerebrosidase (GBA (show GBA Proteins)), alpha-galactosidase A (GLA (show GLA Proteins)), alpha-iduronidase (IDUA (show IDUA Proteins)) and sphingomyeline phosphodiesterase-1 (SMPD-1)) were measured on ~43,000 de-identified dried blood spot (DBS (show MCF2L Proteins)) punches, and screen positive samples were submitted for DNA sequencing to obtain genotype confirmation of disease risk
This study shows that the ASM alternative splicing pattern could be a biological target with diagnostic relevance and could serve as a novel biomarker for Major depressive disorder
stress-induced activation of p38 MAPK (show MAPK14 Proteins) and apoptosis in endothelial cells and established the link between the acid sphingomyelinase/ceramide and p38 MAPK (show MAPK14 Proteins) pathways.
Elevated acid sphingomyelinase (ASM) activity in the lung tumor environment and blood serum of patients with non-small cell lung cancer (NSCLC).
Smpd1 deficiency protects mice against adipocyte hypertrophy and Western diet-induced liver steatosis.
During hypercholesterolemia NLRP3 (show NLRP3 Proteins) inflammasome formation and IL-1beta (show IL1B Proteins) production significantly increase in the intima of Asm+/+ mice but not in Asm-/- mice.
Genetic ablation or pharmacological inhibition of Smpd1 reduced joint swelling and levels of pro-inflammatory cytokines in the arthritic joint.
The results show that mice lacking acid sphingomyelinase had a significant increase in myelin recovery and a significantly higher oligodendrocyte cell count after 2 weeks remyelination compared to wildtype littermates.
These findings suggest that the paradoxical antidepressant effects of alcohol in depressed organisms are mediated by ASM and its control of sphingolipid homeostasis
this study shows that Asm-deficient mice develop brain measles virus infection that is consistent with an enhanced Treg frequency and/or activity
K8/K18 (show KRT18 Proteins)-dependent PKCdelta (show PKCd Proteins)- and ASMase-mediated modulation of lipid raft size can explain the more prominent FasR-mediated signaling resulting from K8/K18 (show KRT18 Proteins) loss.
Aged platelets elicit lung injury in primed recipient mice, which can be alleviated by pharmacological inhibition or genetic deletion of acid sphingomyelinase.
Transgenic ASM female, but not male, mice showed an impaired social preference and a depressive- and anxiogenic-like phenotype, which could be normalized by amitriptyline treatment.
Acid sphingomyelinase activation serves as a triggering mechanism, leading to fusion of membrane proximal lysosomes into lipid rafts clusters on the cell membrane of coronary arterial endothelial cells.
The protein encoded by this gene is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. The encoded protein also has phospholipase C activity. Defects in this gene are a cause of Niemann-Pick disease type A (NPA) and Niemann-Pick disease type B (NPB). Multiple transcript variants encoding different isoforms have been identified.
, sphingomyelin phosphodiesterase
, sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase)
, sphingomyelin phosphodiesterase 1, acid lysosomal
, sphingomyelin phosphodiesterase 1
, sphingomyelin phosphodiesterase-like