Sphingomyelin phosphodiesterase 1, Acid Lysosomal Proteins (SMPD1)

The protein encoded by SMPD1 is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. Additionally we are shipping Sphingomyelin phosphodiesterase 1, Acid Lysosomal Antibodies (76) and Sphingomyelin phosphodiesterase 1, Acid Lysosomal Kits (36) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SMPD1 6609 P17405
SMPD1 20597 Q04519
Rat SMPD1 SMPD1 308909  
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top Sphingomyelin phosphodiesterase 1, Acid Lysosomal Proteins at antibodies-online.com

Showing 9 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,797.11
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,797.11
Details
Baculovirus infected Insect Cells Human His tag 10 μg Log in to see 14 to 16 Days
$250.80
Details
Baculovirus infected Insect Cells Mouse His tag 20 μg Log in to see 20 to 21 Days
$382.80
Details
Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$640.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 2 to 3 Days
$814.00
Details
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$225.40
Details
Yeast REACT_Tick His tag   1 mg Log in to see 60 to 71 Days
$2,942.50
Details
Baculovirus infected Insect Cells Human His tag SDS-PAGE 50 μg Log in to see 20 to 21 Days
$629.97
Details

SMPD1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, , ,
Mouse (Murine) ,

More Proteins for Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) Interaction Partners

Human Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) interaction partners

  1. the human ASM holoenzyme and product bound structures encompassing all of the functional domains, are presented.

  2. This study sheds light on the molecular mechanism of ASMase function.

  3. The results suggest an association of Acid sphingomyelinase activation with Respiratory Syncytial Virus infection, a cause for common acute illness.

  4. This study identified association between Leu-Ala (Val) repeat variants in SMPD1 and Chinese Han patients with sporadic Parkinson's disease.

  5. Parkinson's disease is associated with mutations in SMPD1 gene in Ashkenazi Jews.

  6. Through genetic analysis it was determined that genetic variants in SMPD1 increase the risk of Parkinson's Disease in the Chinese Han population.

  7. Enzyme activities (acid alpha-glucosidase (GAA), galactocerebrosidase (GALC (show GALC Proteins)), glucocerebrosidase (GBA (show GBA Proteins)), alpha-galactosidase A (GLA (show GLA Proteins)), alpha-iduronidase (IDUA (show IDUA Proteins)) and sphingomyeline phosphodiesterase-1 (SMPD-1)) were measured on ~43,000 de-identified dried blood spot (DBS (show MCF2L Proteins)) punches, and screen positive samples were submitted for DNA sequencing to obtain genotype confirmation of disease risk

  8. This study shows that the ASM alternative splicing pattern could be a biological target with diagnostic relevance and could serve as a novel biomarker for Major depressive disorder

  9. stress-induced activation of p38 MAPK (show MAPK14 Proteins) and apoptosis in endothelial cells and established the link between the acid sphingomyelinase/ceramide and p38 MAPK (show MAPK14 Proteins) pathways.

  10. Elevated acid sphingomyelinase (ASM) activity in the lung tumor environment and blood serum of patients with non-small cell lung cancer (NSCLC).

Mouse (Murine) Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) interaction partners

  1. Smpd1 deficiency protects mice against adipocyte hypertrophy and Western diet-induced liver steatosis.

  2. This study sheds light on the molecular mechanism of ASMase function.

  3. During hypercholesterolemia NLRP3 (show NLRP3 Proteins) inflammasome formation and IL-1beta (show IL1B Proteins) production significantly increase in the intima of Asm+/+ mice but not in Asm-/- mice.

  4. Genetic ablation or pharmacological inhibition of Smpd1 reduced joint swelling and levels of pro-inflammatory cytokines in the arthritic joint.

  5. The results show that mice lacking acid sphingomyelinase had a significant increase in myelin recovery and a significantly higher oligodendrocyte cell count after 2 weeks remyelination compared to wildtype littermates.

  6. These findings suggest that the paradoxical antidepressant effects of alcohol in depressed organisms are mediated by ASM and its control of sphingolipid homeostasis

  7. this study shows that Asm-deficient mice develop brain measles virus infection that is consistent with an enhanced Treg frequency and/or activity

  8. K8/K18 (show KRT18 Proteins)-dependent PKCdelta (show PKCd Proteins)- and ASMase-mediated modulation of lipid raft size can explain the more prominent FasR-mediated signaling resulting from K8/K18 (show KRT18 Proteins) loss.

  9. Aged platelets elicit lung injury in primed recipient mice, which can be alleviated by pharmacological inhibition or genetic deletion of acid sphingomyelinase.

  10. Transgenic ASM female, but not male, mice showed an impaired social preference and a depressive- and anxiogenic-like phenotype, which could be normalized by amitriptyline treatment.

Cow (Bovine) Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) interaction partners

  1. Acid sphingomyelinase activation serves as a triggering mechanism, leading to fusion of membrane proximal lysosomes into lipid rafts clusters on the cell membrane of coronary arterial endothelial cells.

Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) Protein Profile

Protein Summary

The protein encoded by this gene is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. The encoded protein also has phospholipase C activity. Defects in this gene are a cause of Niemann-Pick disease type A (NPA) and Niemann-Pick disease type B (NPB). Multiple transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with SMPD1

  • sphingomyelin phosphodiesterase 1 (SMPD1)
  • sphingomyelin phosphodiesterase 1, acid lysosomal (Smpd1)
  • sphingomyelin phosphodiesterase (LOC5578088)
  • sphingomyelin phosphodiesterase 1 (Smpd1)
  • sphingomyelin phosphodiesterase 1, acid lysosomal (SMPD1)
  • A-SMase protein
  • ASM protein
  • aSMase protein
  • NPD protein
  • SMPD1 protein
  • Zn-SMase protein

Protein level used designations for SMPD1

acid sphingomyelinase , sphingomyelin phosphodiesterase , sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase) , aSMase , sphingomyelin phosphodiesterase 1, acid lysosomal , sphingomyelin phosphodiesterase 1 , sphingomyelin phosphodiesterase-like

GENE ID SPECIES
6609 Homo sapiens
20597 Mus musculus
485334 Canis lupus familiaris
5578088 Aedes aegypti
308909 Rattus norvegicus
450990 Pan troglodytes
505097 Bos taurus
711248 Macaca mulatta
100030863 Monodelphis domestica
100172518 Pongo abelii
100307047 Ovis aries
100353898 Oryctolagus cuniculus
100400920 Callithrix jacchus
100720041 Cavia porcellus
Selected quality suppliers for Sphingomyelin phosphodiesterase 1, Acid Lysosomal Proteins (SMPD1)
Did you look for something else?