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promotes cell adhesion and outgrowth of embryonic hippocampal neurons [RGD, Feb 2006].. Additionally we are shipping SPON2 Antibodies (102) and SPON2 Kits (27) and many more products for this protein.
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Human SPON2 Protein expressed in Wheat germ - ABIN1321223
Qian, Li, Pang, Xue, Wang, Zhou: Spondin-2 (SPON2), a more prostate-cancer-specific diagnostic biomarker. in PLoS ONE 2012
Egr-1 (show EGR1 Proteins) regulates mindin expression by directly binding to the mindin promoter; mindin suppresses colon cancer progression by blocking angiogenesis.
Spondin-2 overexpression contributes to tumor aggressiveness and prognosis in gastric cancer.
SPON2 is a transcriptional target of the metastasis gene MACC1 (show MACC1 Proteins). SPON2 induces cell motility in vitro and CRC (show CALR Proteins) metastasis in mice. In patients, SPON2 serves as prognostic indicator for CRC (show CALR Proteins) metastasis and survival, and might represent a promising target for therapeutic approaches.
Data suggest that spondin-2 could be an independent diagnostic and prognostic biomarker of colon cancer.
Mindin protects against vascular hyperplasia by suppression of abnormal VSMC proliferation, migration and phenotypic switching in an AKT (show AKT1 Proteins)-dependent manner.
Using tissue microarray by immunohistostaining, we found SPON2 to be over-expressed in prostate cancer (PCa (show FLVCR1 Proteins)). SPON2 staining was more intense in Gleason score sum 7-8 and in PCa (show FLVCR1 Proteins) patients with metastasis.
mindin serves as a novel mediator that protects against cardiac hypertrophy and the transition to heart failure by blocking AKT (show AKT1 Proteins)/GSK3beta and TGF-beta1 (show TGFB1 Proteins)-Smad (show SMAD1 Proteins) signalling.
High Mindin is associated with diabetic nephropathy in type 2 diabetes.
Spondin 2, which is regulated by T(3), has an important role in cell invasion, cell migration, and hepatoma tumor progression.
The structure of the F-spondin (show SPON1 Proteins) domain of mindin was determined at 1.8-A resolution.
Mindin is a novel modulator of hepatic I/R injury through regulating inflammatory responses, as well as hepatocyte apoptosis and proliferation via inactivation of the Akt (show AKT1 Proteins) signaling pathway.
Spondin 2 regulates hepatic lipid metabolism and alleviates hepatic steatosis, obesity, inflammation, and insulin (show INS Proteins) resistance via its interaction with PPARalpha (show PPARA Proteins).
The data of this study demonstrated that mindin is a critical mediator of ischemic brain injury in an experimental stroke model.
Data show that mindin, as an intrinsic cardioprotective factor, prevents maladaptive remodelling and the transition to heart failure by blocking AKT/GSK3beta signalling.
Mindin expression is upregulated during intestinal inflammation and may induce NF-kappaBp65 promoter activation in a TLR-9 (show TLR9 Proteins) mediated manner.
Mindin is a pattern-recognition molecule for microbial pathogens.
Mindin-integrin interactions play a key role in regulating Rho GTPase (show RACGAP1 Proteins) expression in DCs and DC priming of T lymphocytes.
mindin plays an essential role in the host innate immune response to influenza virus infection and suggest that mindin may be used as an immune-enhancing agent in influenza infection.
mindin participates in integrin-dependent trafficking of eosinophils and can contribute to the severity of allergic airways disease.
promotes cell adhesion and outgrowth of embryonic hippocampal neurons
differentially expressed in cancerous and non-cancerous lung cells 1
, spondin 2a, extracellular matrix protein