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Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. Additionally we are shipping Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) Antibodies (129) and Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) Kits (8) and many more products for this protein.
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sdhB mutant is hypersensitive to oxygen and displays hallmarks of a progeroid syndrome
Mutation in the SDHB gene is associated with mediastinal paraganglioma.
We report for the first time the presence of both TFE3 (show TFE3 Proteins) translocation and SDHB mutation in the same renal cell carcinoma (show MOK Proteins) tumor.
Heterozygous germ line mutations in SDHB neutrophil survival is independent of HIF-1alpha (show HIF1A Proteins) expression and linked to uncoupling of the mitochondrial electron transport chain.
miR (show MLXIP Proteins)-142-5p up-regulation in colorectal cancer probably facilitates generation of aerobic glycolysis by reducing SDHB expression.
SDHB mutation is associated with metastatic pheochromocytoma.
we found a higher estimated penetrance compared to several other studies, and a striking difference in age-related penetrance between male and female SDHB mutation carriers with no association between mutation and gender or tumor location
LASS5 (show LASS5 Proteins) interacts with SDHB and synergistically represses p53 (show TP53 Proteins) and p21 (show CDKN1A Proteins) activity.
A novel SDHB germline mutation in a paraganglioma
SDHB-related tumours are picked up as early as 2 years after initial negative surveillance scan
miR (show MLXIP Proteins)-183 cluster (miR (show MLXIP Proteins)-96/182/183) are related to clinical parameters and SDHB expression in pheochromocytomas.
tissue expression analysis indicated that that swine SDHB, SNRPA (show SNRPA Proteins) and CRYBB1 (show CRYBB1 Proteins) gene were differentially expressed in tissues including fat, lung, muscle, small intestine, kidney, large intestine, spleen and liver
Data show that lack of succinate dehydrogenase (SDH (show SDHA Proteins)) activity commits cells to consume extracellular pyruvate.
Using Sdhb(+/-) mice, we provide evidence that pituitary hyperplasia in SDHx-deficient cells may be the initial abnormality in the cascade of events leading to pituitary adenoma formation.
Tumor-derived FH and SDH (show SDS Proteins) mutations accumulate fumarate and succinate, leading to enzymatic inhibition of multiple alpha-KG-dependent dioxygenases and consequent alterations of genome-wide histone and DNA methylation (show HELLS Proteins).
Data show that two subunits of complex II (succinate dehydrogenase (show SDHD Proteins), or SDH (show SDS Proteins)), SDHA (show SDHA Proteins) and SDHB, interacted specifically with SIRT3 (show SIRT3 Proteins).
Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.
succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
, succinate dehydrogenase complex subunit B
, COMPLEX II: iron-sulfur subunit
, iron-sulfur protein subunit of succinate dehydrogenase
, succinate dehydrogenase
, succinate dehydrogenase B
, succinate dehydrogenase Iron-sulfur
, succinate dehydrogenase Iron-sulfur protein
, succinate dehydrogenase iron protein
, succinate dehydrogenase subunit b
, iron-sulfur subunit of complex II
, Iron-sulfur subunit of complex II