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The succinate dehydrogenase (SDH) complex (or complex II) of the mitochondrial respiratory chain is composed of 4 individual subunits. Additionally we are shipping SDHAF1 Antibodies (41) and SDHAF1 Kits (4) and many more products for this protein.
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that SDHAF1 contributes to iron-sulfur (Fe-S) cluster incorporation into the Fe-S subunit of CII, SDHB (show SDHB Proteins).
Studies indicate that an array of tumor syndromes caused by complex II-associated mutations in genes SDHA (show SDHA Proteins), SDHB (show SDHB Proteins), SDHC (show SDHC Proteins), SDHD (show SDHD Proteins), SDHAF1 and SDHAF2 (show Sdhaf2 Proteins) have been identified over a decade.
Leukoencephalopathy with accumulated succinate is a key symptom of defective complex II assembly due to SDHAF1 mutations
Myocardial ischemic reperfusion injury in Sirt5 (show SIRT5 Proteins)-/- heart is restored to wild-type levels by pretreatment with dimethyl malonate, a competitive inhibitor of succinate dehydrogenase (SDH (show SDHA Proteins)), implicating alteration in SDH (show SDS Proteins) activity as causative of the injury.
The succinate dehydrogenase (SDH) complex (or complex II) of the mitochondrial respiratory chain is composed of 4 individual subunits. The protein encoded by this gene resides in the mitochondria, and is essential for SDH assembly, but does not physically associate with the complex in vivo. Mutations in this gene are associated with SDH-defective infantile leukoencephalopathy (mitochondrial complex II deficiency).
succinate dehydrogenase complex assembly factor 1
, succinate dehydrogenase assembly factor 1, mitochondrial
, LYR motif-containing protein 8
, SDH assembly factor 1
, LYR motif containing 8