Succinate Dehydrogenase Complex Assembly Factor 2 Proteins (Sdhaf2)

Sdhaf2 encodes a mitochondrial protein needed for the flavination of a succinate dehydrogenase complex subunit required for activity of the complex. Additionally we are shipping Sdhaf2 Antibodies (11) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Sdhaf2 54949 Q9NX18
Sdhaf2 66072 Q8C6I2
Sdhaf2 361726 Q5RJQ7
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Top Sdhaf2 Proteins at antibodies-online.com

Showing 8 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
$5,370.21
Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
$5,370.21
Details
Escherichia coli (E. coli) Human His tag 100 μg 15 to 19 Days
$400.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$888.80
Details
Yeast Zebrafish His tag   1 mg 60 to 71 Days
$2,253.17
Details
Yeast Cow His tag   1 mg 60 to 71 Days
$2,289.83
Details
Yeast Rat His tag   1 mg 60 to 71 Days
$2,289.83
Details
Escherichia coli (E. coli) Human His tag   1 mg 2 to 3 Days
$3,655.38
Details

Sdhaf2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for Succinate Dehydrogenase Complex Assembly Factor 2 (Sdhaf2) Interaction Partners

Human Succinate Dehydrogenase Complex Assembly Factor 2 (Sdhaf2) interaction partners

  1. Loss of SDHAF2 gene is associated with paragangliomas.

  2. The SDHA, TMEM127, MAX, and SDHAF2 genes contribute to hereditary pheochromocytoma and paraganglioma.

  3. data show that SDHA flavination is independent of SDHAF2 in breast cancer cells, employing an alternative mechanism.

  4. FAD interacts noncovalently with SDHA in the absence of SDH5

  5. Autosomal dominant susceptibility for Paraganglioma is modified by imprinting and mutations in the SDHAF2 gene cause Paragangliomas only when the mutation is inherited from father.

  6. Loss of heterozygosity was found in more than 50 % of the von Hippel-Lindau-associated pheochromocytomas, and was correlated with a significant decrease (p < 0.05) in both SDHAF2 and SDHD mRNA expression, which may be suggestive of a pathogenic role.

  7. New mutation found in SDHAF2 gene in pheochromocytoma/paraganglioma patients.

  8. Data indicate that SDH5 is protected from mitochondrial LON (LONM)-mediated degradation in mitochondria by its stable interaction with SDHA, a state that is dysregulated in hereditary paraganglioma 2 (PGL2).

  9. Data indicate that succinate dehydrogenase 5 (SDH5) functions as a critical protein in regulating epithelial-mesenchymal transition (EMT) by modulating the glycogen synthase kinase (GSK)-3beta-beta-catenin signaling pathway.

  10. Studies indicate that mutations in the mitochondrial complex II structural subunit genes SDHB, SDHC and SDHD and the regulatory subunit gene SDHAF2 in many paraganglioma families.

  11. Studies indicate that an array of tumor syndromes caused by complex II-associated mutations in genes SDHA, SDHB, SDHC, SDHD, SDHAF1 and SDHAF2 have been identified over a decade.

  12. Studies indicate that the flavinylation factor Sdh5 (SDHAF2) provided insight into the possible mechanism associated with Sdh1 (SDHA) flavinylation.

  13. We established the SDHAF2 mutation status of PGL2 family members

  14. Somatic mutations of the SDHAF2 tumor suppressor gene are unlikely to frequently contribute to parathyroid tumor development in sporadic primary hyperparathyroidism.

  15. germline loss-of-function mutations in the SDH5 gene segregate with disease in a family with hereditary paraganglioma

Sdhaf2 Protein Profile

Protein Summary

This gene encodes a mitochondrial protein needed for the flavination of a succinate dehydrogenase complex subunit required for activity of the complex. Mutations in this gene are associated with paraganglioma.

Gene names and symbols associated with Sdhaf2

  • succinate dehydrogenase complex assembly factor 2 (SDHAF2)
  • succinate dehydrogenase complex assembly factor 2 (Sdhaf2)
  • succinate dehydrogenase complex assembly factor 2 (sdhaf2)
  • 0610038F07Rik protein
  • AA407634 protein
  • AW049997 protein
  • C11orf79 protein
  • C14H11orf79 protein
  • PGL2 protein
  • RGD1309216 protein
  • SDH5 protein
  • wu:fj30e04 protein
  • zgc:163000 protein

Protein level used designations for Sdhaf2

succinate dehydrogenase complex assembly factor 2 , succinate dehydrogenase assembly factor 2, mitochondrial , SDH assembly factor 2 , Protein EMI5 homolog, mitochondrial , succinate dehydrogenase subunit 5, mitochondrial , hSDH5

GENE ID SPECIES
476065 Canis lupus familiaris
693401 Macaca mulatta
100173895 Pongo abelii
100353725 Oryctolagus cuniculus
54949 Homo sapiens
66072 Mus musculus
767983 Bos taurus
361726 Rattus norvegicus
569482 Danio rerio
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