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Sdhaf2 encodes a mitochondrial protein needed for the flavination of a succinate dehydrogenase complex subunit required for activity of the complex. Additionally we are shipping Sdhaf2 Antibodies (13) and and many more products for this protein.
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Loss of SDHAF2 gene is associated with paragangliomas.
The SDHA (show SDHA Proteins), TMEM127, MAX, and SDHAF2 genes contribute to hereditary pheochromocytoma and paraganglioma.
data show that SDHA (show SDHA Proteins) flavination is independent of SDHAF2 in breast cancer cells, employing an alternative mechanism.
FAD (show BRCA2 Proteins) interacts noncovalently with SDHA (show SDHA Proteins) in the absence of SDH5
Autosomal dominant susceptibility for Paraganglioma is modified by imprinting and mutations in the SDHAF2 gene cause Paragangliomas only when the mutation is inherited from father.
Loss of heterozygosity was found in more than 50 % of the von Hippel-Lindau-associated pheochromocytomas, and was correlated with a significant decrease (p < 0.05) in both SDHAF2 and SDHD (show SDHD Proteins) mRNA expression, which may be suggestive of a pathogenic role.
New mutation found in SDHAF2 gene in pheochromocytoma/paraganglioma patients.
Data indicate that SDH5 is protected from mitochondrial LON (show LONP1 Proteins) (LONM)-mediated degradation in mitochondria by its stable interaction with SDHA (show SDHA Proteins), a state that is dysregulated in hereditary paraganglioma 2 (PGL2).
Data indicate that succinate dehydrogenase (show SDHA Proteins) 5 (SDH5) functions as a critical protein in regulating epithelial-mesenchymal transition (EMT (show ITK Proteins)) by modulating the glycogen synthase kinase (GSK)-3beta-beta-catenin (show CTNNB1 Proteins) signaling pathway.
Studies indicate that mutations in the mitochondrial complex II structural subunit genes SDHB (show SDHB Proteins), SDHC (show SDHC Proteins) and SDHD (show SDHD Proteins) and the regulatory subunit gene SDHAF2 in many paraganglioma families.
This gene encodes a mitochondrial protein needed for the flavination of a succinate dehydrogenase complex subunit required for activity of the complex. Mutations in this gene are associated with paraganglioma.
succinate dehydrogenase complex assembly factor 2
, succinate dehydrogenase assembly factor 2, mitochondrial
, SDH assembly factor 2
, Protein EMI5 homolog, mitochondrial
, succinate dehydrogenase subunit 5, mitochondrial