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Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Additionally we are shipping Sulfiredoxin 1 Kits (8) and Sulfiredoxin 1 Proteins (2) and many more products for this protein.
Showing 10 out of 38 products:
Human Polyclonal SRX1 Primary Antibody for IF (p), IHC (p) - ABIN1387599
Zhou, Zhou, Yu, Wu, Chen, Zhao et al.: Sulfiredoxin-1 exerts anti-apoptotic and neuroprotective effects against oxidative stress-induced injury in rat cortical astrocytes following exposure to oxygen-glucose deprivation and hydrogen ... in International journal of molecular medicine 2015
Human Polyclonal SRX1 Primary Antibody for ELISA, WB - ABIN450073
Jönsson, Johnson, Lowther: Structure of the sulphiredoxin-peroxiredoxin complex reveals an essential repair embrace. in Nature 2008
Study identify a role for Srxn1 as a denitrosylase for neuronal Prx2 (show PRDX2 Antibodies). Finding points to the NO/Srxn1 pair in a previously unrecognized redox cycle that modulates Prx2 (show PRDX2 Antibodies) peroxidase activity.
Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) pathway was stimulated by sulfiredoxin in tumor cell line, with activation of CD44 (show CD44 Antibodies)-its target genes-resulting in the promotion of invasion and migration in cervical cancer cell lines.
The up-regulated expression of Srx was significantly associated with lymph node metastasis, infiltration of vessels, and the depth of cancer invasion.
The analysis of SXR (show NR1I2 Antibodies) polymorphism is a promising tool to predict both the favourable response to corticosteroids and the risk of developing steroid resistance
rs6053666 of SRXN1 is associated with cerebrovascular disease in a Finnish cohort
Increased expression of Srx protects peroxiredoxins against hyperoxidation in the early stage of hyperglycaemia.
We silenced Srx by short hairpin RNA in HeLa and SiHa cells. Diminished Srx expression upregulated E-cadherin (show CDH1 Antibodies) expression. The cell invasion and migration activity in the ShSrx group were obviously decreased in HeLa and SiHa cells.
Study shows that Srx plays a critical oncogenic role to promote cell invasion and metastasis, which is at least partially due to its stimulation of the MAPK (show MAPK1 Antibodies) pathway through EGFR (show EGFR Antibodies) deacetylation.
This review will summarize the molecular basis of differences in the affinity of Srx for individual Prx (show PRDX6 Antibodies) and the role of individual component of the Srx-Prx (show PRDX6 Antibodies) system in tumor progression and metastasis.
Gemfibrozil, a lipid-lowering drug, increases myelin genes in human oligodendrocytes via peroxisome proliferator-activated receptor-beta (show PPARD Antibodies).
sulfiredoxin is degraded by Lon (show LONP1 Antibodies) in a manner dependent on PrxIII (show PRDX3 Antibodies) hyperoxidation state.
Srx is one of the critical components that contribute to mouse skin tumorigenesis in vivo.
data provide in vivo evidence that loss of Srx renders mice resistant to azoxymethane/dextran sulfate sodium-induced colon carcinogenesis, suggesting that Srx has a critical oncogenic role in cancer development
The concerted action of PrxIII (show PRDX3 Antibodies) and Srx is important for protection against pyrazole-induced oxidative stress arising from the convergent induction of CYP2E1 (show CYP2E1 Antibodies)-derived and ER stress-derived ROS (show ROS1 Antibodies) in mitochondria.
Srx functions as a novel component to maintain the balance between H2O2 production and elimination
NO-mediated Srx up-regulation is mediated by the transcription factor nuclear factor erythroid 2-related factor (Nrf2 (show NFE2L2 Antibodies)) and the NO/Srx pathway inhibits generation of reactive oxygen species.
LPS (show TLR4 Antibodies)-mediated Srx induction is dependent on both AP-1 (show JUN Antibodies) and Nrf2 (show NFE2L2 Antibodies), which is regulated by Nox2 (show CYBB Antibodies)-derived reactive oxygen species.
Synaptic activity upregulated the thioredoxin (show TXN Antibodies)-peroxiredoxin reactivating gene sulfiredoxin.
Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase.
, sulfiredoxin 1 homolog
, sulfiredoxin 1 homolog (S. cerevisiae)
, neoplastic progression 3
, neoplastic progression protein 3