Suppressor of Variegation 4-20 Homolog 2 (Drosophila) Proteins (SUV420H2)

SUV420H2 and the related enzyme SUV420H1 (MIM 610881) function as histone methyltransferases that specifically trimethylate nucleosomal histone H4 (see MIM 602822) on lysine-20 (K20) (Schotta et al., 2004 [PubMed 15145825]).[supplied by OMIM, Dec 2009].. Additionally we are shipping Suppressor of Variegation 4-20 Homolog 2 (Drosophila) Antibodies (21) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SUV420H2 84787 Q86Y97
SUV420H2 232811 Q6Q783
SUV420H2 308345 P0C2N6
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Top Suppressor of Variegation 4-20 Homolog 2 (Drosophila) Proteins at antibodies-online.com

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,797.11
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,797.11
Details
Escherichia coli (E. coli) Human GST tag,His tag 50 μg Log in to see 20 to 21 Days
$382.80
Details
Escherichia coli (E. coli) Mouse Un-conjugated SDS-PAGE analysis of Mouse SUV420H2 Protein. 100 μg Log in to see 11 to 18 Days
$625.39
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Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,325.67
Details
Escherichia coli (E. coli) Human GST tag SUV420H2 protein gel. SUV420H2 run on an SDS-PAGE gel and stained with Coomassie blue. 50 μg Log in to see 1 to 2 Days
$466.67
Details

SUV420H2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
, ,
Mouse (Murine) ,

Rat (Rattus)

More Proteins for Suppressor of Variegation 4-20 Homolog 2 (Drosophila) (SUV420H2) Interaction Partners

Human Suppressor of Variegation 4-20 Homolog 2 (Drosophila) (SUV420H2) interaction partners

  1. Study provides evidence that Suv420h2 controls the H4K20 methylome of osteoblasts and is critical for normal progression of osteoblastogenesis.

  2. Altogether, these results reveal Suv4-20h-mediated histone H4K20 tri (show VANGL2 Proteins)-methylation as a critical determinant in the selection of active replication initiation sites in heterochromatin regions of mammalian genomes.

  3. The sequences surrounding both methylation sites do not fit to the specificity profile of SUV4-20H1 (show SUV420H1 Proteins).

  4. Upregulation of long non-coding RNA PAPAS (show PSTPIP1 Proteins) in response to hypoosmotic stress does not increase H4K20me3 because of Nedd4 (show NEDD4 Proteins)-dependent ubiquitinylation and proteasomal degradation of Suv4-20h2.

  5. One of the most downregulated genes in response to SUV420H2 expression was the Src (show SRC Proteins) substrate, tensin-3 (show TNS3 Proteins), a focal adhesion protein that contributes to cancer cell migration.

  6. The crystal structure of SUV420H2 was used to characterize substrate selectivity and product specificity.

  7. SUV420H1 (show SUV420H1 Proteins) and SUV420H2 isoforms have different in their cellular localization and effects on myogenic differentiation

  8. data indicate that H4K20me3 invokes gene repression by antagonizing hMOF (show KAT8 Proteins)-mediated H4K16Ac

  9. The decrease in trimethylation of lysine 20 of histone H4 in breast cancer cells was accompanied by diminished expression of Suv4-20h2 histone methyltransferase.

Mouse (Murine) Suppressor of Variegation 4-20 Homolog 2 (Drosophila) (SUV420H2) interaction partners

  1. expression of Suv4-20h2 leads to sustained levels of H4K20me3, developmental arrest, and defects in S-phase progression.

  2. Upregulation of long non-coding RNA PAPAS (show PSTPIP1 Proteins) in response to hypoosmotic stress does not increase H4K20me3 because of Nedd4-dependent ubiquitinylation and proteasomal degradation of Suv4-20h2.

  3. Results uncover a lncRNA-mediated mechanism that guides Suv4-20h2 to specific genomic loci to establish a more compact chromatin structure in growth-arrested cells.

  4. Data suggest that Suv4-20h1 (show SUV420H1 Proteins)/Suv4-20h2 activity is required for fidelity of chromosome distribution during meiosis in oocyte; Suv4-20h1 (show SUV420H1 Proteins)/Suv4-20h2 appear to control histone 4 methylation, centromere structure, and oocyte maturation/oogenesis.

  5. Suv4-20h2 is involved in the initial loading or maintenance of cohesion subunits

  6. SUV420H1 (show SUV420H1 Proteins) and SUV420H2 isoforms have different in their cellular localization and effects on myogenic differentiation

Suppressor of Variegation 4-20 Homolog 2 (Drosophila) (SUV420H2) Protein Profile

Protein Summary

SUV420H2 and the related enzyme SUV420H1 (MIM 610881) function as histone methyltransferases that specifically trimethylate nucleosomal histone H4 (see MIM 602822) on lysine-20 (K20) (Schotta et al., 2004

Gene names and symbols associated with SUV420H2

  • lysine methyltransferase 5C (KMT5C)
  • lysine methyltransferase 5C (kmt5c)
  • suppressor of variegation 4-20 homolog 2 (Drosophila) (SUV420H2)
  • lysine (K)-specific methyltransferase 5C L homeolog (kmt5c.L)
  • lysine methyltransferase 5C (Kmt5c)
  • BC024816 protein
  • KMT5C protein
  • Suv4-20h2 protein
  • zgc:162876 protein

Protein level used designations for SUV420H2

suppressor of variegation 4-20 homolog 2 (Drosophila) , Suv4-20-like , suppressor of variegation 4-20 protein-like 2 , histone-lysine N-methyltransferase SUV420H2-like , histone-lysine N-methyltransferase SUV420H2 , su(var)4-20 homolog 2 , suv4-20h2 , lysine N-methyltransferase 5C

GENE ID SPECIES
484295 Canis lupus familiaris
519777 Bos taurus
569041 Danio rerio
699963 Macaca mulatta
735868 Pan troglodytes
100055743 Equus caballus
100478438 Ailuropoda melanoleuca
100519093 Sus scrofa
100599527 Nomascus leucogenys
779432 Xenopus laevis
84787 Homo sapiens
232811 Mus musculus
308345 Rattus norvegicus
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