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Has an actin-binding and actin-bundling activity (By similarity).. Additionally we are shipping Synaptopodin 2 Kits (12) and Synaptopodin 2 Proteins (5) and many more products for this protein.
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Data suggest that fesselin stabilizes myosin filaments and tethers myosin to actin; the rate of dissociation of myosin filaments (but not heavy meromyosin) from actin is greatly reduced by fesselin.
Fesselin has been cloned and its cDNA derived amino acid sequence has been detemined.
These findings uncover a suppressive role of SYNPO2 in triple-negative breast cancer (TNBC) metastasis via inhibition of YAP/TAZ, and suggest that SYNPO2 might provide a potential prognosis marker and novel therapeutic strategy.
LMOD1, SYNPO2, PDLIM7, PLN, and SYNM down-regulation reflect the altered phenotype of smooth muscle cells in vascular disease and could be early sensitive markers of SMC dedifferentiation.
Results show that SYNPO2 gene plays an important role in the etiology of epithelial ovarian cancer, suggesting that this gene may be a potential genetic modifier for developing epithelial ovarian cancer.
High Myopodin methylation is associated with metastasis in kidney cancer.
High Synaptopodin-2 induces assembly of peripheral actin bundles and immature focal adhesions to promote lamellipodia formation and prostate cancer cell migration.
Promoter hypermethylation and down regulation of SYNPO2 has significance in the prognosis of melanoma patients.
myopodin is epigenetically modified in colon cancer
the N-terminus of myopodin binds integrin-linked kinase (ILK) both in vivo and in vitro
myopodin functions as a tumor suppressor gene to limit the growth and to inhibit the metastasis of cancer cells
Imp13 functions in myopodin import and the regulation of this event is critical for normal and abnormal cellular differentiation.
The myopodin new isoform (Myo2), in addition to the two predicted isoforms (Myo1 and Myo3), are transcribed in various mammalian tumor cell lines.
The subcellular localization of myopodin is involved in its suppressor or activator function in tumorigenesis.
The identification of myopodin as a direct target of PKA, CaMKII, and calcineurin defines a novel intracellular signaling pathway whereby changes in Z-disc dynamics may translate into compartmentalized signal transduction in the heart.
Has an actin-binding and actin-bundling activity (By similarity).
, Synaptopodin 2-like
, genethonin 2