anti-T-Cell Leukemia Homeobox 1 (TLX1) Antibodies

TLX1 encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox genes. Additionally we are shipping TLX1 Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TLX1 21908  
TLX1 3195 P31314
TLX1 499361  
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Top anti-TLX1 Antibodies at antibodies-online.com

Showing 10 out of 52 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-TLX1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:1562500  Positive Control:  721_B cell lysate TLX1 is supported by BioGPS gene expression data to be expressed in 721_B WB Suggested Anti-TLX1  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500  Positive Control:.21_B cell lysate  TLX1 is supported by BioGPS gene expression data to be expressed in 721_B 100 μL 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-TLX1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  Human heart 100 μL 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-TLX1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  Human heart 100 μL 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, WB TLX1 Antibody (Center) western blot analysis in mouse kidney tissue lysates (35 µg/lane). This demonstrates the TLX1 antibody detected the TLX1 protein (arrow). 0.4 mL 6 to 8 Days
$484.00
Details
Bat Rabbit Un-conjugated IHC, IHC (p), WB Human Thymus (formalin-fixed, paraffin-embedded) stained with TLX1 antibody ABIN297247 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Anti-TLX1 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 50 μg 11 to 14 Days
$484.00
Details
Bat Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$551.83
Details
Bat Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$551.83
Details
Bat Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated IHC (p), WB 50 μg 6 to 8 Days
$495.00
Details
Human Rabbit Un-conjugated ELISA, IHC, IHC (p), WB Anti-TLX1 / HOX11 antibody IHC staining of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. 0.05 mg 11 to 14 Days
$484.00
Details

More Antibodies against TLX1 Interaction Partners

Mouse (Murine) T-Cell Leukemia Homeobox 1 (TLX1) interaction partners

  1. High TLX1 expression is associated with castration-resistant prostate cancer.

  2. data supports multiple roles for Hox11 genes following fracture injury in the adult skeleton

  3. TLX1-dependent regulation of retinoic acid metabolism is critical for spleen organogenesis.

  4. Loss of Hox11 function leads to fracture repair defects, including reduced cartilage formation and delayed ossification.

  5. Tlx1(CreER-Venus) mice represent a new tool for lineage tracing and conditional gene manipulation of spleen mesenchymal cells during morphogenesis.

  6. Hox11 genes are expressed in the connective tissue fibroblasts of the outer perichondrium, tendons and muscle connective tissue of the zeugopod region throughout all stages of development.

  7. Tlx1/3 and Ptf1a, the key transcription factors for fate determination of glutamatergic and GABAergic neurons in the dorsal spinal cord

  8. Results demonstrate that the transcriptional activity of HOX11 is regulated by phosphorylation of Thr247 in a cell cycle-specific manner and that this phosphorylation modulates the expression of the target gene, cyclin B1.

  9. Hox11 paralogous genes regulate wrist and ankle joint organization and are essential for establishing carpal and tarsal element boundary and maintaining their articulating surface tissue.

  10. Seven conserved Cdx binding sites were found in the Hoxa 11 promoter, suggesting regulatory sites.

  11. dysregulated expression of a particular set of downstream target genes by DNA binding via the homeodomain is of central importance for leukemia initiation mediated by HOX11 homeodomain protein

  12. results have shown that the Hox10 and Hox11 paralogous genes are global regulators of the lumbosacral region of the axial skeleton and are integral in patterning principal limb elements

  13. These studies establish a Pbx1-Hox11-dependent genetic and transcriptional pathway in spleen ontogeny.

  14. HOX11/TLX1 stem cells from the spleen of normal mice have been harvested to assist in both the treatment and cure at least two autoimmune diseases.

  15. Before the usual time of the onset of type 1 diabetes or Sjogren's syndrome, we show that all four Hox11-derived organs are structurally abnormal in both NOD mice and NOD-SCID mice versus controls.

Human T-Cell Leukemia Homeobox 1 (TLX1) interaction partners

  1. oncogenic kinase NUP214-ABL1, through its downstream effector STAT5, directly cooperates with TLX1 at the transcriptional level.

  2. High TLX1 expression is associated with castration-resistant prostate cancer.

  3. Our data suggest that loss of DLX5, TLX1 and HOXA10 expression in late gestation is required for proper placental differentiation and function.

  4. TLX1 hypermethylation is associated with colorectal cancer.

  5. The occurrence of G-quadruplex structures at the HOX11 breakpoint region explain its fragility during the t(10;14) translocation.

  6. these results place TLX1 and TLX3 at the top of an oncogenic transcriptional network controlling leukemia development, and identify RUNX1 as a tumor-suppressor gene in T-ALL

  7. The cortical thymic maturation arrest in T-lineage Acute lymphoblastic leukemias (ALLs) that overexpress TLX1 or TLX3 is due to binding of TLX1/TLX3 to ETS1.

  8. Suppression of TLX1 expression slowed the growth of TLX1 tumor cell lines. Suppression of TLX1 in vivo also transiently delayed leukemia progression.

  9. conclude that the TLX1/NOTCH/MYC network is a central determinant promoting the growth and survival of TLX1+ T-ALL cells. In addition, the TLX1/NOTCH/MYC transcriptional network coregulates genes involved in T cell development

  10. Transgenic expression of human TLX1 in mice induces T cell acute lymphoblastic leukemia with frequent deletions and mutations in Bcl11b.

  11. co-operation between TLX1 and MEIS proteins may have a significant role in T-cell leukemogenesis.

  12. A PBX2 Regulatory Element PRE-1048 has been identified which contains a novel DNA-binding sequence and mediates significant activation of the HOX11 gene in K562 cells.

  13. Seven conserved Cdx binding sites were found in the Hoxa 11 promoter, suggesting regulatory sites.

  14. Hox11 expression is linked to chromosomes 5 and 14 in T-cell malignancies in children.

  15. HOX11 manifests its regulatory function via its action as a transcription factor

  16. transcriptional deregulation of G1/S growth-control genes, mediated in large part through blockade of PP1/PP2A phosphatase activity, plays an important role in HOX11 pathobiology

  17. HOX11 overexpression leads to a heightened predisposition for development of aneuploidy, contributing to oncogenesis

  18. TLX1/HOX11 overexpression and Ubr1 inactivation in promoting chromosome missegregation, permitting the accrual of additional chromosome losses and cytogenic abnormalities en route to malignancy.

  19. TLX1-mediated differentiation arrest may be achieved in part through a mechanism that involves redirection of CBP and/or its sequestration in repressive chromatin domains

  20. TLX1(+) T-cell acute lymphoblastic leukemias be defined as cases expressing TLX1/ABL ratios greater than 1 and/or demonstrating TLX1 rearrangement

Zebrafish T-Cell Leukemia Homeobox 1 (TLX1) interaction partners

  1. Detrmination site by nested polymerase chain reaction the integration sites in TLX1-immortalized hematopoietic cell lines.

  2. identification and expression patterns of three members of the zebrafish Tlx family

TLX1 Antigen Profile

Protein Summary

This gene encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox genes. The encoded protein is required for normal development of the spleen during embryogenesis. This protein is also involved in specification of neuronal cell fates. Ectopic expression of this gene due to chromosomal translocations is associated with certain T-cell acute lymphoblastic leukemias. Alternate splicing results in multiple transcript variants.

Gene names and symbols associated with TLX1

  • T cell leukemia, homeobox 1 (Tlx1) antibody
  • T-cell leukemia homeobox 1 (TLX1) antibody
  • T-cell leukemia homeobox 1 L homeolog (tlx1.L) antibody
  • T-cell leukemia, homeobox 1 (Tlx1) antibody
  • T-cell leukemia, homeobox 1 (tlx1) antibody
  • Hox-11 antibody
  • hox11 antibody
  • RGD1563655 antibody
  • SI:dZ46P4.1 antibody
  • TCL3 antibody
  • Tlx-1 antibody
  • tlx1-a antibody
  • XHox11 antibody
  • XHox11L2 antibody
  • ztlx-1 antibody

Protein level used designations for TLX1

T-cell leukemia homeobox protein 1 , T-cell leukemia, homeobox 1 , homeobox TLX-1 , homeobox protein Hox-11 , T-cell leukemia/lymphoma protein 3 , homeo box-11 (T-cell leukemia-3 associated breakpoint, homologous to Drosophila Notch) , proto-oncogene TCL-3 , homeobox protein 11

GENE ID SPECIES
21908 Mus musculus
3195 Homo sapiens
373832 Xenopus laevis
395868 Gallus gallus
608311 Canis lupus familiaris
505304 Bos taurus
499361 Rattus norvegicus
266964 Danio rerio
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