T-Cell Lymphoma Invasion and Metastasis 1 Proteins (TIAM1)

Mouse (Murine) T-Cell Lymphoma Invasion and Metastasis 1 (TIAM1) interaction partners

1. Therefore, these results suggest that Tiam1 is an important regulator of intima hyperplasia. It may regulate vascular intimal hyperplasia through the activation of Rac1.

2. Findings indicate the role of Tiam1-Rac1-Nox2 (show CYBB Proteins) signaling pathway in the onset of spontaneous diabetes in the type 1 diabetes NOD mouse model.

3. Tiam1 and P-Rex1 promote Rac1 anti- and pro-migratory signalling cascades.

4. S1466 of Tiam1 is a novel Cdk1 (show CDK1 Proteins) site whose phosphorylation is required for Tiam1's mitotic function.

5. endometrial Tiam1/Rac1 signal down-regulation along with miR (show MLXIP Proteins)-22 up-regulation during embryo implantation window in the natural menstrual cycle may be one of the reasons for the failure of embryo implantation in patients with repeated implantation failure

6. The MAP1B (show MAP1B Proteins)-Tiam1-Rac1 relay is essential for spine structural plasticity and removal of AMPA (show GRIA3 Proteins) receptors from synapses during long-term depression.

7. Tiam1 is a regulator of the dopaminergic neurons development acting in the Wnt/Dvl/Rac1 pathway.

8. Tiam1, a specific activator of the small GTPase (show RACGAP1 Proteins) Rac (show AKT1 Proteins), is required for the polarized outgrowth of protrusions in primary astrocytes during the initial phase of cell polarization after scratch-wounding monolayers of cells.

9. Embryonic Tiam-1 expression plays a critical role during early brain development in mice.

10. Study shows that the NR2C (show GRIN2C Proteins) and Tiam1 maturation genes are synergistically controlled by the activity-dependent induction of Etv1 (show ETV1 Proteins).

Human T-Cell Lymphoma Invasion and Metastasis 1 (TIAM1) interaction partners

1. Competing interactions of EndoA3 with membrane versus TIAM1 modulate hyperproliferative and metastatic phenotypes. Disruption of EndoA3-membrane interactions stimulates TIAM1 and small GTPases in vitro, and further promotes pro-metastatic phenotypes in vivo.

2. PDZ domains direct protein-protein interactions and serve as models for protein design. This study optimized a protein design energy function for the Tiam1 and Cask PDZ domains that combines a molecular mechanics energy, Generalized Born solvent, and an empirical unfolded state model.

3. Clinical outcome was improved in tumors where a TIAM1 variant was present concomitantly with either ALK mutation or MYCN (show MYCN Proteins) amplification.

4. the Ser179Glu mutant of SDC-4 (show SDC4 Proteins) binds strongly Tiam1, a Rac1-GEF (show SLC2A4RG Proteins) reducing Rac1-GTP (show AK3 Proteins) by 3-fold in MCF-7 breast adenocarcinoma cells.

5. results highlight the role of the PHn-CC-Ex domain in Tiam1 GEF regulation and suggest a combinatorial model for GEF inhibition and activation of the Rac1 signaling pathway.

6. Tiam1 expression is frequently up-regulated in breast cancer. Tiam1 expression correlated with clinicopathological parameters.

7. In colorectal carcinoma TIAM1 suppresses tumor progression by regulating YAP (show YAP1 Proteins)/TAZ (show TAZ Proteins) activity.

8. The expression of TIAM1 is closely related to the occurrence, development and metastasis of oral squamous cell carcinoma , and it can be used as a new marker for reflecting its biological behaviors.

9. TIAM1 was aberrantly expressed in the oral squamous cell carcinoma group compared with the normal group. Furthermore, high expression of TIAM1 was significantly correlated with lymph node metastasis and the timing of recurrence.

10. These data suggest a novel link between Tiam1 and RhoG/ILK /ELMO2 pathway as upstream effectors of the Rac1-mediated phagocytic process in trabecular meshwork cells.

Cow (Bovine) T-Cell Lymphoma Invasion and Metastasis 1 (TIAM1) interaction partners

1. G protein betagamma subunits, Src kinase (show CSK Proteins) and the GEF (show SLC2A4RG Proteins) Tiam1 are upstream modulators of S1P (show MBTPS1 Proteins)-mediated Rac1 activation, and Rac1 has a role in S1P (show MBTPS1 Proteins)-mediated activation of PI 3 (show PI3 Proteins)-kinase/Akt (show AKT1 Proteins)/endothelial nitric-oxide synthase (show NOS3 Proteins) signaling in vascular endothelial cells