TAF4 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 135kDa Proteins (TAF4)

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. Additionally we are shipping TAF4 Antibodies (23) and TAF4 Kits (13) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TAF4 6874 O00268
TAF4 3645198  
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Top TAF4 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Yeast Candida albicans His tag   1 mg Log in to see 60 to 71 Days
Yeast Schizosaccharomyces pombe His tag   1 mg Log in to see 60 to 71 Days
Yeast Yeast His tag   1 mg Log in to see 60 to 71 Days

TAF4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Yeast (Saccharomyces cerevisiae)

Candida albicans

More Proteins for TAF4 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 135kDa (TAF4) Interaction Partners

Fruit Fly (Drosophila melanogaster) TAF4 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 135kDa (TAF4) interaction partners

  1. Daat suggest that holo-TFIID (show TAF8 Proteins) comprises a stable core subcomplex containing TAF4, TAF5 (show TAF5 Proteins), TAF6 (show TAF6 Proteins), TAF9 (show TAF9 Proteins), and TAF12 (show TAF12 Proteins) decorated with peripheral subunits TAF1 (show TAF1 Proteins), TAF2 (show TAF2 Proteins), TAF11, and TBP (show TBP Proteins).

Human TAF4 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 135kDa (TAF4) interaction partners

  1. Identification of heteromolecular binding sites in transcription factors Sp1 (show PSG1 Proteins) and TAF4 using high-resolution nuclear magnetic resonance spectroscopy has been reported.

  2. Data suggest that many TATA-box-containing promoters contain a TFIIA (show GTF2A1 Proteins) recognition element (IIARE) that activates transcription by increasing the recruitment of RNA polymerase II, TFIIA (TF2A1 (show GTF2A1 Proteins)/TF2A2 (show GTF2A2 Proteins) subunits), TAF4, and P300 (show EP300 Proteins). (TAF4 = TATA box binding protein (TBP (show TBP Proteins))-associated factor (show TAF5 Proteins), RNA polymerase II, C1; P300 (show EP300 Proteins) = E1A binding protein p300 (show EP300 Proteins))

  3. the two Q-domains of Sp1 (show PSG1 Proteins) and four Q-domains of TAF4 were disordered under physiological conditions.

  4. TAF4 isoforms generated by the alternative splicing participate in the conversion of the cellular transcriptional programs from the maintenance of stem cell state to differentiation

  5. These interactions are important to the transcriptional activation of these genes by Rta (show RBM9 Proteins) since introducing TAF4 shRNA substantially reduces the ability of Rta (show RBM9 Proteins) to activate these promoters

  6. huntingtin (show HTT Proteins) interacts with Sp1 (show PSG1 Proteins) and TAFII130; transcriptional activity of SP1 (show PSG1 Proteins) and TAFII130 disrupted in early Huntingtin's Disease

  7. Data present the crystal structure of a complex formed by the interacting domains from two subunits of the general transcription factor TFIID, the human TATA binding protein-associated factors hTAF4 (hTAF(II)135) and hTAF12 (hTAF(II)20).

  8. TAF4b incorporation into TFIID induces an open conformation at the lobe involved in TFIIA & putative activator interactions, correlating with differential activator-dependent transcription & promoter recognition by 4b/4-IID.

  9. Findings suggest that DNA binding by TAF4/4b-TAF12 facilitates the association of TFIID with the core promoter of a subset of genes.

TAF4 Protein Profile

Protein Summary

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that has been shown to potentiate transcriptional activation by retinoic acid, thyroid hormone and vitamin D3 receptors. In addition, this subunit interacts with the transcription factor CREB, which has a glutamine-rich activation domain, and binds to other proteins containing glutamine-rich regions. Aberrant binding to this subunit by proteins with expanded polyglutamine regions has been suggested as one of the pathogenetic mechanisms underlying a group of neurodegenerative disorders referred to as polyglutamine diseases.

Gene names and symbols associated with TAF4

  • TBP-associated factor 4 (Taf4)
  • Taf4p (TAF4)
  • TATA-box binding protein associated factor 4 (TAF4)
  • TATA-box binding protein associated factor 4 L homeolog (taf4.L)
  • CG5444 protein
  • d110 protein
  • Dmel\\CG5444 protein
  • dmTAF4 protein
  • dTAF4 protein
  • dTAFII110 protein
  • dTAF[[II]]110 protein
  • l(3)72Dj protein
  • p110 protein
  • SR3-3 protein
  • SY3-2 TAF110 protein
  • TAF protein
  • TAF2C protein
  • TAF2C1 protein
  • TAF4 protein
  • TAF4A protein
  • taf110 protein
  • TAFII110 protein
  • TAFII130 protein
  • TAFII135 protein
  • TAF[II]110 protein
  • TAF[[II]] protein
  • Taf[[II]]110 protein
  • TFIID protein
  • TFIID 110 protein

Protein level used designations for TAF4

CG5444-PA , CG5444-PB , CG5444-PC , CG5444-PD , CG5444-PE , CG5444-PF , CG5444-PG , CG5444-PH , TATA-associated factor 110 , TBP associated factor 110 , TBP-associated factor , TBP-associated factor 110 , TBP-associated factor 110kD , Taf4-PA , Taf4-PB , Taf4-PC , Taf4-PD , Taf4-PE , Taf4-PF , Taf4-PG , Taf4-PH , lethal(3)72Dj , hypothetical protein , RNA polymerase II TBP-associated factor subunit C , TAF(II)130 , TAF(II)135 , TAF4A RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135 kD , TAFII-130 , TAFII-135 , TATA box binding protein (TBP)-associated factor, RNA polymerase II, C1, 130kD , TBP-associated factor 4 , transcription initiation factor TFIID 130 kDa subunit , transcription initiation factor TFIID 135 kD subunit , transcription initiation factor TFIID 135 kDa subunit , transcription initiation factor TFIID subunit 4

39765 Drosophila melanogaster
3645198 Candida albicans SC5314
6874 Homo sapiens
100037075 Xenopus laevis
419223 Gallus gallus
477280 Canis lupus familiaris
100626452 Sus scrofa
789854 Bos taurus
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