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Tumor necrosis factor (TNF\; see MIM 191160) receptor-associated factors, such as TRAF7, are signal transducers for members of the TNF receptor superfamily (see MIM 191190). Additionally we are shipping TRAF7 Proteins (3) and and many more products for this protein.
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Horse (Equine) Polyclonal TRAF7 Primary Antibody for IP, WB - ABIN269571
Zotti, Uva, Ferravante, Vessichelli, Scudiero, Ceccarelli, Vito, Stilo: TRAF7 protein promotes Lys-29-linked polyubiquitination of IkappaB kinase (IKKgamma)/NF-kappaB essential modulator (NEMO) and p65/RelA protein and represses NF-kappaB activation. in The Journal of biological chemistry 2011
TRAF7 is involved in signal transduction pathways that lead either to activation or repression of NF-kappaB transcription factor.
These results suggest a new mechanism by which MyoD1 function is coupled to NF-kappaB activity through Traf7, regulating the balance between cell cycle progression and differentiation during myogenesis.
TRAF7 negatively regulates c-Myb activity by sequestering c-Myb to the cytosol via sumoylation.
TRAF7 mutations icause intraneural perineuriomas.
TRAF7 is a direct target of miR-126 in human umbilical cord vascular endothelial cells.
Downregulation of ubiquitin E3 ligase TNF receptor-associated factor 7 leads to stabilization of p53 in breast cancer.
The findings of this study suggested an essential contribution of combined KLF4 K409Q and TRAF7 mutations in the genesis of secretory meningioma and demonstrate a role for TRAF7 alterations in other non-NF2 meningiomas.
Nearly one-fourth of all meningiomas have mutations in TRAF7.
an important role for TRAF7 in the activation of JNK following TNFalpha stimulation and involvement of this protein in regulating the turnover of c-FLIP
this study identifies TRAF7 as a NEMO- and p65-interacting molecule and brings important information on the ubiquitination events that control NF-kappaB transcriptional activity.
TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis
Tumor necrosis factor (TNF\; see MIM 191160) receptor-associated factors, such as TRAF7, are signal transducers for members of the TNF receptor superfamily (see MIM 191190). TRAFs are composed of an N-terminal cysteine/histidine-rich region containing zinc RING and/or zinc finger motifs\; a coiled-coil (leucine zipper) motif\; and a homologous region that defines the TRAF family, the TRAF domain, which is involved in self-association and receptor binding.
TNF receptor-associated factor 7
, ring finger and WD repeat domain 1
, E3 ubiquitin-protein ligase TRAF7
, e3 ubiquitin-protein ligase TRAF7-like
, RING finger and WD repeat-containing protein 1
, RING finger protein 119