anti-Tachykinin, Precursor 1 (TAC1) Antibodies

TAC1 encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. Additionally we are shipping Tachykinin, Precursor 1 Kits (136) and Tachykinin, Precursor 1 Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
Anti-Human TAC1 TAC1 6863 P20366
Anti-Rat TAC1 TAC1 24806 P06767
Anti-Mouse TAC1 TAC1 21333 P41539
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Top anti-Tachykinin, Precursor 1 Antibodies at

Showing 10 out of 217 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
REACT_Bird Rabbit Un-conjugated IEM, ICC, IF, IHC IHC image of staining in rat spinal cord 0.1 mL Log in to see 2 to 3 Days
Cow Rabbit Un-conjugated WB WB Suggested Anti-TAC1 Antibody Titration: 1.0 ug/ml Positive Control: 721_B Whole Cell 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat liver labeled with Rabbit Anti-Substance P Polyclonal Antibody (ABIN724400) at 1:200 followed by conjugation to the secondary antibody and DAB staining. Formalin-fixed and paraffin embedded rat brain tissue labeled with Rabbit Anti-Substance P Polyclonal Antibody (ABIN724400) 1:200 followed by conjugation to the secondary antibody and DAB staining. 100 μL Log in to see 3 to 7 Days
Human Guinea Pig Un-conjugated ICC, IHC (fro), IF, IHC Immunocytochemistry/Immunofluorescence: Substance P Antibody [ABIN152529] - Detection of Substance P in rat spinal cord dorsal horn (red fluorescence). DAPI (blue) was used as counter stain. 0.05 mL Log in to see 8 to 11 Days
Human Rabbit Un-conjugated WB Western blot analysis of Protachykinin 1 expression in HEK293T (A), SP2/0 (B), H9C2 (C) whole cell lysates. 200 μL Log in to see 13 to 14 Days
Human Rabbit Un-conjugated ELISA, ICC, IF, IHC, WB Western blot analysis of extracts of 293, using TAC1 antibody. The lane on the left is treated with the antigen-specific peptide. ABIN6276804 staining HepG2? cells by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25¡ãC. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37¡ãC. An  Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody(Cat.# S0006), diluted at 1/600, was used as secondary antibod 100 μL Log in to see 11 to 12 Days
Cow Rabbit Un-conjugated IHC, WB   200 μL Log in to see 13 to 14 Days
Human Rabbit Un-conjugated FACS, WB TAC1 Antibody (C-term) (ABIN652053) western blot analysis in 293 cell line lysates (35 µg/lane). This demonstrates the TAC1 antibody detected the TAC1 protein (arrow). 400 μL Log in to see 10 to 11 Days
Guinea Pig Mouse Un-conjugated EIA, IHC (fro), IF 0.1 mg Log in to see 6 to 8 Days
Chicken Rabbit Un-conjugated IHC (fro), IF, IHC (p) Staining of paraffin embedded human appendix with rabbit anti Substance P (ABIN114011). 0.5 mL Log in to see 6 to 8 Days

Top referenced anti-Tachykinin, Precursor 1 Antibodies

  1. Bird (Avian) Polyclonal TAC1 Primary Antibody for IEM, ICC - ABIN617879 : Hara, Kobayashi: Glycerol injection to the rat trigeminal nerve: histological and immunohistochemical studies. in Acta neurochirurgica 1993 (PubMed)
    Show all 502 Pubmed References

  2. Human Polyclonal TAC1 Primary Antibody for ICC, IHC (fro) - ABIN152529 : Kavut, Kalpaklıoğlu, Atasoy: Contribution of neurogenic and allergic ways to the pathophysiology of nonallergic rhinitis. in International archives of allergy and immunology 2013 (PubMed)
    Show all 7 Pubmed References

  3. Human Polyclonal TAC1 Primary Antibody for IF (p), IHC (p) - ABIN724400 : Tu, Li, Peng, Hu, Liu, Kong, Liu, Gao, Xu, Xu, Qiu, Fan, Zhu, Yu, Zheng, Wu, Peng, Song, Wu, Liang: P2X(7) inhibition in stellate ganglia prevents the increased sympathoexcitatory reflex via sensory-sympathetic coupling induced by myocardial ischemic injury. in Brain research bulletin 2013 (PubMed)
    Show all 4 Pubmed References

  4. Mammalian Monoclonal TAC1 Primary Antibody for IHC - ABIN284858 : Joad, Avadhanam, Watt, Kott, Bric, Pinkerton: Effects of extended sidestream smoke exposure on components of the C-fiber axon reflex. in Toxicology 1996 (PubMed)
    Show all 4 Pubmed References

  5. Pig (Porcine) Monoclonal TAC1 Primary Antibody for IHC (f) - ABIN2689911 : Cuello, Galfre, Milstein: Detection of substance P in the central nervous system by a monoclonal antibody. in Proceedings of the National Academy of Sciences of the United States of America 1979 (PubMed)
    Show all 4 Pubmed References

  6. Chicken Polyclonal TAC1 Primary Antibody for IHC (fro), IF - ABIN2476628 : Mueller, Rex, Figueroa, Greene, Brater: A pharmacokinetic and endoscopic comparison of an oral and an experimental buccal piroxicam formulation. in Pharmacotherapy 1992 (PubMed)
    Show all 3 Pubmed References

  7. Amphibian Monoclonal TAC1 Primary Antibody for IHC (fro), IF - ABIN2476629 : Pioro, Hughes, Cuello: Loss of substance P immunoreactivity in the nucleus of the spinal trigeminal tract after intradural tumour compression of the trigeminal nerve. in Neuroscience letters 1985 (PubMed)
    Show all 4 Pubmed References

  8. Human Monoclonal TAC1 Primary Antibody for ICC, IF - ABIN256146 : Pelayo, Veldhuis, Eriksson, Bunnett, Poole: Localisation and activation of the neurokinin 1 receptor in the enteric nervous system of the mouse distal colon. in Cell and tissue research 2014 (PubMed)

More Antibodies against Tachykinin, Precursor 1 Interaction Partners

Human Tachykinin, Precursor 1 (TAC1) interaction partners

  1. The results of this study show a significant upregulation of TAC1 in the medial area frontopolaris which is a node in the limbic-cortical network and known to be susceptible for gray matter loss and behavioral dysfunction in patients with depression.

  2. Serial monitoring of plasma neurokinin A (NKA) levels is useful in identifying patients who have a poor prognosis, and elevated NKA levels can indicate the need for immediate therapeutic intervention.

  3. SP can protect the vascular endothelium against inflammation-induced damage through modulation of the Akt/eNOS/NO signaling pathway.

  4. Preincubation of LAD2 cells with the natural flavonoid methoxyluteolin (1-100 mM) inhibits (P < 0.0001) secretion and gene expression of IL-1beta, procaspase-1, and pro-IL-1beta. Mast cell secretion of IL-1beta in response to SP and IL-33 reveals targets for the development of antiinflammatory therapies.

  5. High TAC1 expression is associated with primary central nervous system lymphoma.

  6. These findings reported here for the first time suggest an important role for a SP/NK1R system, either as genetic and/or epigenetic factor, in both the cytoplasm and nucleus functions of the adipose stem cells.

  7. This study showed that ADMA, carbonyl groups, CAT and NKA can be useful markers of chronic stress in both males and females with depression, PTSD, and depression concurrent with PTSD.

  8. Inhibition of SP through use of a neurokinin 1 (NK1) antagonist is highly beneficial following both traumatic brain injury (TBI) and ischaemic stroke in pre-clinical models. The role of CGRP is more unclear, especially with respect to TBI, with both elevations and reductions in CGRP levels reported following trauma

  9. serum SP levels during the first week could be used as a biomarker of sepsis mortality.

  10. elevated plasma SP level, up-regulated expression of SP and NK1R indicate that the SP/NK1R complex is important in the development of Atopic dermatitis.

  11. High methylation of TAC1 is associated with head and neck cancer.

  12. Data suggest that serum substance P concentrations at the day of oocyte retrieval after ovulation induction may be used to predict oocyte maturation during in vitro oocyte maturation to be followed by intracytoplasmic sperm injections and may be an indirect indicator for treatment outcome in women with infertility.

  13. expressed in mural granulosa and cumulus cells

  14. Expression substance P/neurokinin A/hemokinin-1 and their preferred neurokinin 1/neurokinin 2 receptors are dysregulated in uterine leiomyomata.

  15. These results suggest that Substance P can retain the therapeutic effect of adipose-derived stem cells by elevating their proliferative and paracrine potential in ex vivo culture.

  16. Data suggest that endogenous tachykinin ligands for neurokinin-1 receptor exhibit large variations in binding/activation kinetics; substance P exhibits fast association kinetics; neurokinin A exhibits slow association kinetics.

  17. Mapping the co-localization of the circadian proteins PER2 and BMAL1 with enkephalin and substance P throughout the rat forebrain has been reported.

  18. Circulating Neurokinin A >/= 50 ng/L is a strong indicator of poor prognosis when Neurokinin A remains above this concentration

  19. Substance P enhances tissue factor release from granulocyte-macrophage colony-stimulating factor-dependent macrophages via the p22phox/beta-arrestin 2/Rho A signaling pathway.

  20. Decrease of mGluR5 receptor density goes parallel with changes in enkephalin and substance P immunoreactivity in Huntington's disease

Mouse (Murine) Tachykinin, Precursor 1 (TAC1) interaction partners

  1. Combined with the recent findings that GABA depresses taste-evoked ATP secretion, the current results indicate that SP elicited secretion of GABA, which provided negative feedback onto Type II (receptor) cells to reduce taste-evoked ATP secretion.

  2. these results show that substance P regulates the production of LTB4 via PKCalpha/MAPK pathway, which further promotes AP-associated ALI through neutrophil reverse transendothelial cell migration

  3. This study demonstrated that BoNT/A antinociceptive activity is dependent on integrity of SP/NKA and NK1R.

  4. elevated plasma SP level, up-regulated expression of SP and NK1R indicate that the SP/NK1R complex is important in the development of Atopic dermatitis.

  5. SP treatment inhibited inflammatory responses by modulating cytokine production as well as the balance of Tregs/Th 17 cells and the M1/M2 transition in lymphoid organs, leading to accelerated tissue repair.

  6. This study demonstrated that there is an additional population of neurons that transiently express Preprotachykinin A in the mouse superficial spinal dorsal horn including cells that respond to noxious and pruritic stimuli.

  7. Evidence for a role of Tac1 in the control of reproductive function in the male mouse, suggesting a predominant central action that may involve a change in the balance of neural factors that control GnRH expression.

  8. This study demonstrated that Activity of Tachykinin1-Expressing Pet1 Raphe Neurons Modulates the Respiratory Chemoreflex.

  9. RNA-binding protein Msi1 competes with miR130a and -206 for interaction with TAC1 mRNA, to stabilize and increase its translation

  10. Results reveal that EM-2, Leu-Enk and Dyn A were down-regulated in Tac1-/- spinal cord tissues.

  11. Results provide evidence linking enhanced waking activity and the pro-inflammatory molecule substance P to changes in slow-wave activity associated with sleep-active cortical cells that co-express nNOS and the NK-1R

  12. Substance P partly accounts for the increased density of microglia in the substantia nigra through chemotaxic recruitment via a novel NK1R-NOX2 axis-mediated pathway.

  13. The spatial structures of human, mouse, and rat hemokinin-1 protein isoforms have been presented.

  14. We conclude that a dedicated subset of VMHVL neurons marked by ERalpha, NKX2-1, and Tac1 regulates estrogen-dependent fluctuations in physical activity and constitutes one of several neuroendocrine modules that drive sex-specific responses.

  15. Data demonstrate a role TAC1 in the control energy balance by regulating the levels of adiposity in response to ghrelin administration and to changes in the status of the gonadal function.

  16. Absence of substance P and the sympathetic nervous system impact on bone structure and chondrocyte differentiation in an adult model of endochondral ossification.

  17. In vivo ozone(O3)-induced elevations in both nerve growth factor (NGF) and substance P (SP) are mediated by the inflammatory cytokine interleukin-1beta. Further, inhibition of NGF reduced O3 induced increases of SP in both the lung BALF and lung tissue.

  18. potent regulation of gonadotropin release by the SP/NK1R and NKA/NK2R systems in the presence of kisspeptin-Kiss1r signaling

  19. This study demonistration that Acid could mediate a prolonged antinociceptive signaling via the release of substance P from muscle afferent neurons in a non-ASIC3, non-TRPV1 manner.

  20. Basal postoperative microcirculation on the plantar skin of PACAP(-/-) mice did not differ from the wildtypes, but was significantly lower in Tac1(-/-) and Tacr1(-/-) ones.

Cow (Bovine) Tachykinin, Precursor 1 (TAC1) interaction partners

  1. Substance P alters the cytokine and chemokine expression pattern in monocytes and blood-monocyte-derived macrophages.

Rabbit Tachykinin, Precursor 1 (TAC1) interaction partners

  1. This study evaluates the remote effects of dry needling with different dosages on the expressions of substance P (SP) in the proximal muscle, spinal dorsal horns of rabbits.

  2. There is an increase in the sensitivity of rapidly adapting receptor (RAR) activity to substance P (SP) during high altitude exposure.

  3. Increased substance P-production precedes tendinosis, since tendinosis-like changes occur only after a minimum of 3 weeks of exercise

Tachykinin, Precursor 1 (TAC1) Antigen Profile

Protein Summary

This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with TAC1

  • tachykinin precursor 1 (TAC1) antibody
  • tachykinin, precursor 1 (Tac1) antibody
  • tachykinin 1 (Tac1) antibody
  • tachykinin precursor 1 (tac1) antibody
  • tachykinin precursor 1 L homeolog (tac1.L) antibody
  • 4930528L02Rik antibody
  • beta-PPT-A antibody
  • Hs.2563 antibody
  • NK-1 antibody
  • NK1 antibody
  • nk2 antibody
  • NKA antibody
  • nkna antibody
  • npk antibody
  • PPT antibody
  • PPT-A antibody
  • Ppt5fl antibody
  • PPTA antibody
  • PPTA3 antibody
  • RATPPTA3 antibody
  • SP antibody
  • TAC antibody
  • tac1 antibody
  • tac2 antibody
  • tachykinin antibody

Protein level used designations for TAC1

PPT , neurokinin 1 , neurokinin 2 , neurokinin A , neurokinin alpha , neuromedin L , neuropeptide K , neuropeptide gamma , preprotachykinin , protachykinin-1 , substance K , substance P , tachykinin 2 , tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma) , Tachykinin (substance P, neurokinin A, neuropeptide K, neuropeptide gamma) , tachykinin 1 , tachykinin, precursor 1 , delta preprotachykinin I , preprotachykinin A , protachykinin-1 preproprotein , preprotachykinin I , substance P, neuropeptide gamma, neurokinin A , Substance P , tachykinin precursor 1 L homeolog

6863 Homo sapiens
24806 Rattus norvegicus
475239 Canis lupus familiaris
697350 Macaca mulatta
100034669 Ovis aries
100379583 Cavia porcellus
100528498 Ictalurus punctatus
21333 Mus musculus
281512 Bos taurus
420573 Gallus gallus
100009275 Oryctolagus cuniculus
100052324 Equus caballus
735077 Xenopus laevis
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