anti-Tachykinin, Precursor 1 (TAC1) Antibodies

Human Tachykinin, Precursor 1 (TAC1) interaction partners

1. Increased serum SP levels and NK1R tissue distribution were observed in patients with breast cancer as compared with their controls.

2. Based on the results shown here, CGRP can mitigate augmenting effects of SP on BMP2 signaling and the three pathways potentially converge on Runx2 to regulate BMP2-induced bone differentiation.

3. The results of this study show a significant upregulation of TAC1 in the medial area frontopolaris which is a node in the limbic-cortical network and known to be susceptible for gray matter loss and behavioral dysfunction in patients with depression.

4. Serial monitoring of plasma neurokinin A (NKA) levels is useful in identifying patients who have a poor prognosis, and elevated NKA levels can indicate the need for immediate therapeutic intervention.

5. SP can protect the vascular endothelium against inflammation-induced damage through modulation of the Akt/eNOS/NO signaling pathway.

6. Preincubation of LAD2 cells with the natural flavonoid methoxyluteolin (1-100 mM) inhibits (P < 0.0001) secretion and gene expression of IL-1beta, procaspase-1, and pro-IL-1beta. Mast cell secretion of IL-1beta in response to SP and IL-33 reveals targets for the development of antiinflammatory therapies.

7. High TAC1 expression is associated with primary central nervous system lymphoma.

8. These findings reported here for the first time suggest an important role for a SP/NK1R system, either as genetic and/or epigenetic factor, in both the cytoplasm and nucleus functions of the adipose stem cells.

9. This study showed that ADMA, carbonyl groups, CAT and NKA can be useful markers of chronic stress in both males and females with depression, PTSD, and depression concurrent with PTSD.

10. Inhibition of SP through use of a neurokinin 1 (NK1) antagonist is highly beneficial following both traumatic brain injury (TBI) and ischaemic stroke in pre-clinical models. The role of CGRP is more unclear, especially with respect to TBI, with both elevations and reductions in CGRP levels reported following trauma

11. serum SP levels during the first week could be used as a biomarker of sepsis mortality.

12. elevated plasma SP level, up-regulated expression of SP and NK1R indicate that the SP/NK1R complex is important in the development of Atopic dermatitis.

13. High methylation of TAC1 is associated with head and neck cancer.

14. Data suggest that serum substance P concentrations at the day of oocyte retrieval after ovulation induction may be used to predict oocyte maturation during in vitro oocyte maturation to be followed by intracytoplasmic sperm injections and may be an indirect indicator for treatment outcome in women with infertility.

15. expressed in mural granulosa and cumulus cells

16. Expression substance P/neurokinin A/hemokinin-1 and their preferred neurokinin 1/neurokinin 2 receptors are dysregulated in uterine leiomyomata.

17. These results suggest that Substance P can retain the therapeutic effect of adipose-derived stem cells by elevating their proliferative and paracrine potential in ex vivo culture.

18. Data suggest that endogenous tachykinin ligands for neurokinin-1 receptor exhibit large variations in binding/activation kinetics; substance P exhibits fast association kinetics; neurokinin A exhibits slow association kinetics.

19. Mapping the co-localization of the circadian proteins PER2 and BMAL1 with enkephalin and substance P throughout the rat forebrain has been reported.

20. Circulating Neurokinin A >/= 50 ng/L is a strong indicator of poor prognosis when Neurokinin A remains above this concentration

Mouse (Murine) Tachykinin, Precursor 1 (TAC1) interaction partners

1. absence of SP presumably results in a slight reduction of bone resorption rate but concomitantly in a critical reduction of bone formation and mineralization rate.

2. Tac1-expressing neurons in the periaqueductal grey region promote itching-scratching cycles.

3. Combined with the recent findings that GABA depresses taste-evoked ATP secretion, the current results indicate that SP elicited secretion of GABA, which provided negative feedback onto Type II (receptor) cells to reduce taste-evoked ATP secretion.

4. these results show that substance P regulates the production of LTB4 via PKCalpha/MAPK pathway, which further promotes AP-associated ALI through neutrophil reverse transendothelial cell migration

5. This study demonstrated that BoNT/A antinociceptive activity is dependent on integrity of SP/NKA and NK1R.

6. elevated plasma SP level, up-regulated expression of SP and NK1R indicate that the SP/NK1R complex is important in the development of Atopic dermatitis.

7. SP treatment inhibited inflammatory responses by modulating cytokine production as well as the balance of Tregs/Th 17 cells and the M1/M2 transition in lymphoid organs, leading to accelerated tissue repair.

8. This study demonstrated that there is an additional population of neurons that transiently express Preprotachykinin A in the mouse superficial spinal dorsal horn including cells that respond to noxious and pruritic stimuli.

9. Evidence for a role of Tac1 in the control of reproductive function in the male mouse, suggesting a predominant central action that may involve a change in the balance of neural factors that control GnRH expression.

10. This study demonstrated that Activity of Tachykinin1-Expressing Pet1 Raphe Neurons Modulates the Respiratory Chemoreflex.

11. RNA-binding protein Msi1 competes with miR130a and -206 for interaction with TAC1 mRNA, to stabilize and increase its translation

12. Results reveal that EM-2, Leu-Enk and Dyn A were down-regulated in Tac1-/- spinal cord tissues.

13. Results provide evidence linking enhanced waking activity and the pro-inflammatory molecule substance P to changes in slow-wave activity associated with sleep-active cortical cells that co-express nNOS and the NK-1R

14. Substance P partly accounts for the increased density of microglia in the substantia nigra through chemotaxic recruitment via a novel NK1R-NOX2 axis-mediated pathway.

15. The spatial structures of human, mouse, and rat hemokinin-1 protein isoforms have been presented.

16. We conclude that a dedicated subset of VMHVL neurons marked by ERalpha, NKX2-1, and Tac1 regulates estrogen-dependent fluctuations in physical activity and constitutes one of several neuroendocrine modules that drive sex-specific responses.

17. Data demonstrate a role TAC1 in the control energy balance by regulating the levels of adiposity in response to ghrelin administration and to changes in the status of the gonadal function.

18. Absence of substance P and the sympathetic nervous system impact on bone structure and chondrocyte differentiation in an adult model of endochondral ossification.

19. In vivo ozone(O3)-induced elevations in both nerve growth factor (NGF) and substance P (SP) are mediated by the inflammatory cytokine interleukin-1beta. Further, inhibition of NGF reduced O3 induced increases of SP in both the lung BALF and lung tissue.

20. potent regulation of gonadotropin release by the SP/NK1R and NKA/NK2R systems in the presence of kisspeptin-Kiss1r signaling

Cow (Bovine) Tachykinin, Precursor 1 (TAC1) interaction partners

1. Substance P alters the cytokine and chemokine expression pattern in monocytes and blood-monocyte-derived macrophages.

Rabbit Tachykinin, Precursor 1 (TAC1) interaction partners

1. This study evaluates the remote effects of dry needling with different dosages on the expressions of substance P (SP) in the proximal muscle, spinal dorsal horns of rabbits.

2. There is an increase in the sensitivity of rapidly adapting receptor (RAR) activity to substance P (SP) during high altitude exposure.

3. Increased substance P-production precedes tendinosis, since tendinosis-like changes occur only after a minimum of 3 weeks of exercise