Tachykinin, Precursor 1 Proteins (TAC1)

TAC1 encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. Additionally we are shipping Tachykinin, Precursor 1 Antibodies (220) and Tachykinin, Precursor 1 Kits (141) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TAC1 6863 P20366
Rat TAC1 TAC1 24806 P06767
Mouse TAC1 TAC1 21333 P41539
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Top Tachykinin, Precursor 1 Proteins at antibodies-online.com

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 19 Days
Escherichia coli (E. coli) Human His tag   10 μg Log in to see 15 to 16 Days
Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 11 to 18 Days
Synthetic Human Un-conjugated   100 μg Log in to see 11 to 18 Days
Synthetic Human Un-conjugated   100 μg Log in to see 15 to 18 Days

TAC1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,

More Proteins for Tachykinin, Precursor 1 (TAC1) Interaction Partners

Human Tachykinin, Precursor 1 (TAC1) interaction partners

  1. The results of this study show a significant upregulation of TAC1 in the medial area frontopolaris which is a node in the limbic-cortical network and known to be susceptible for gray matter loss and behavioral dysfunction in patients with depression.

  2. Serial monitoring of plasma neurokinin A (NKA) levels is useful in identifying patients who have a poor prognosis, and elevated NKA levels can indicate the need for immediate therapeutic intervention.

  3. SP can protect the vascular endothelium against inflammation-induced damage through modulation of the Akt/eNOS/NO signaling pathway.

  4. Preincubation of LAD2 cells with the natural flavonoid methoxyluteolin (1-100 mM) inhibits (P < 0.0001) secretion and gene expression of IL-1beta, procaspase-1, and pro-IL-1beta. Mast cell secretion of IL-1beta in response to SP and IL-33 reveals targets for the development of antiinflammatory therapies.

  5. High TAC1 expression is associated with primary central nervous system lymphoma.

  6. These findings reported here for the first time suggest an important role for a SP/NK1R system, either as genetic and/or epigenetic factor, in both the cytoplasm and nucleus functions of the adipose stem cells.

  7. This study showed that ADMA, carbonyl groups, CAT and NKA can be useful markers of chronic stress in both males and females with depression, PTSD, and depression concurrent with PTSD.

  8. Inhibition of SP through use of a neurokinin 1 (NK1) antagonist is highly beneficial following both traumatic brain injury (TBI) and ischaemic stroke in pre-clinical models. The role of CGRP is more unclear, especially with respect to TBI, with both elevations and reductions in CGRP levels reported following trauma

  9. serum SP levels during the first week could be used as a biomarker of sepsis mortality.

  10. elevated plasma SP level, up-regulated expression of SP and NK1R indicate that the SP/NK1R complex is important in the development of Atopic dermatitis.

  11. High methylation of TAC1 is associated with head and neck cancer.

  12. Data suggest that serum substance P concentrations at the day of oocyte retrieval after ovulation induction may be used to predict oocyte maturation during in vitro oocyte maturation to be followed by intracytoplasmic sperm injections and may be an indirect indicator for treatment outcome in women with infertility.

  13. expressed in mural granulosa and cumulus cells

  14. Expression substance P/neurokinin A/hemokinin-1 and their preferred neurokinin 1/neurokinin 2 receptors are dysregulated in uterine leiomyomata.

  15. These results suggest that Substance P can retain the therapeutic effect of adipose-derived stem cells by elevating their proliferative and paracrine potential in ex vivo culture.

  16. Data suggest that endogenous tachykinin ligands for neurokinin-1 receptor exhibit large variations in binding/activation kinetics; substance P exhibits fast association kinetics; neurokinin A exhibits slow association kinetics.

  17. Mapping the co-localization of the circadian proteins PER2 and BMAL1 with enkephalin and substance P throughout the rat forebrain has been reported.

  18. Circulating Neurokinin A >/= 50 ng/L is a strong indicator of poor prognosis when Neurokinin A remains above this concentration

  19. Substance P enhances tissue factor release from granulocyte-macrophage colony-stimulating factor-dependent macrophages via the p22phox/beta-arrestin 2/Rho A signaling pathway.

  20. Decrease of mGluR5 receptor density goes parallel with changes in enkephalin and substance P immunoreactivity in Huntington's disease

Mouse (Murine) Tachykinin, Precursor 1 (TAC1) interaction partners

  1. these results show that substance P regulates the production of LTB4 via PKCalpha/MAPK pathway, which further promotes AP-associated ALI through neutrophil reverse transendothelial cell migration

  2. This study demonstrated that BoNT/A antinociceptive activity is dependent on integrity of SP/NKA and NK1R.

  3. elevated plasma SP level, up-regulated expression of SP and NK1R indicate that the SP/NK1R complex is important in the development of Atopic dermatitis.

  4. SP treatment inhibited inflammatory responses by modulating cytokine production as well as the balance of Tregs/Th 17 cells and the M1/M2 transition in lymphoid organs, leading to accelerated tissue repair.

  5. This study demonstrated that there is an additional population of neurons that transiently express Preprotachykinin A in the mouse superficial spinal dorsal horn including cells that respond to noxious and pruritic stimuli.

  6. Evidence for a role of Tac1 in the control of reproductive function in the male mouse, suggesting a predominant central action that may involve a change in the balance of neural factors that control GnRH expression.

  7. This study demonstrated that Activity of Tachykinin1-Expressing Pet1 Raphe Neurons Modulates the Respiratory Chemoreflex.

  8. RNA-binding protein Msi1 competes with miR130a and -206 for interaction with TAC1 mRNA, to stabilize and increase its translation

  9. Results reveal that EM-2, Leu-Enk and Dyn A were down-regulated in Tac1-/- spinal cord tissues.

  10. Results provide evidence linking enhanced waking activity and the pro-inflammatory molecule substance P to changes in slow-wave activity associated with sleep-active cortical cells that co-express nNOS and the NK-1R

  11. Substance P partly accounts for the increased density of microglia in the substantia nigra through chemotaxic recruitment via a novel NK1R-NOX2 axis-mediated pathway.

  12. The spatial structures of human, mouse, and rat hemokinin-1 protein isoforms have been presented.

  13. We conclude that a dedicated subset of VMHVL neurons marked by ERalpha, NKX2-1, and Tac1 regulates estrogen-dependent fluctuations in physical activity and constitutes one of several neuroendocrine modules that drive sex-specific responses.

  14. Data demonstrate a role TAC1 in the control energy balance by regulating the levels of adiposity in response to ghrelin administration and to changes in the status of the gonadal function.

  15. Absence of substance P and the sympathetic nervous system impact on bone structure and chondrocyte differentiation in an adult model of endochondral ossification.

  16. In vivo ozone(O3)-induced elevations in both nerve growth factor (NGF) and substance P (SP) are mediated by the inflammatory cytokine interleukin-1beta. Further, inhibition of NGF reduced O3 induced increases of SP in both the lung BALF and lung tissue.

  17. potent regulation of gonadotropin release by the SP/NK1R and NKA/NK2R systems in the presence of kisspeptin-Kiss1r signaling

  18. This study demonistration that Acid could mediate a prolonged antinociceptive signaling via the release of substance P from muscle afferent neurons in a non-ASIC3, non-TRPV1 manner.

  19. Basal postoperative microcirculation on the plantar skin of PACAP(-/-) mice did not differ from the wildtypes, but was significantly lower in Tac1(-/-) and Tacr1(-/-) ones.

  20. SP-, CGRP-, and VGLUT2-mediated transmission together were found to play a role in the development of mechanical hyperalgesia after persistent inflammation.

Cow (Bovine) Tachykinin, Precursor 1 (TAC1) interaction partners

  1. Substance P alters the cytokine and chemokine expression pattern in monocytes and blood-monocyte-derived macrophages.

Rabbit Tachykinin, Precursor 1 (TAC1) interaction partners

  1. This study evaluates the remote effects of dry needling with different dosages on the expressions of substance P (SP) in the proximal muscle, spinal dorsal horns of rabbits.

  2. There is an increase in the sensitivity of rapidly adapting receptor (RAR) activity to substance P (SP) during high altitude exposure.

  3. Increased substance P-production precedes tendinosis, since tendinosis-like changes occur only after a minimum of 3 weeks of exercise

Tachykinin, Precursor 1 (TAC1) Protein Profile

Protein Summary

This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Tachykinin, Precursor 1 Proteins (TAC1)

  • tachykinin precursor 1 (TAC1)
  • tachykinin, precursor 1 (Tac1)
  • tachykinin 1 (Tac1)
  • tachykinin precursor 1 (tac1)
  • tachykinin precursor 1 L homeolog (tac1.L)
  • 4930528L02Rik protein
  • beta-PPT-A protein
  • Hs.2563 protein
  • NK-1 protein
  • NK1 protein
  • nk2 protein
  • NKA protein
  • nkna protein
  • npk protein
  • PPT protein
  • PPT-A protein
  • Ppt5fl protein
  • PPTA protein
  • PPTA3 protein
  • RATPPTA3 protein
  • SP protein
  • TAC protein
  • tac1 protein
  • tac2 protein
  • tachykinin protein

Protein level used designations for Tachykinin, Precursor 1 Proteins (TAC1)

PPT , neurokinin 1 , neurokinin 2 , neurokinin A , neurokinin alpha , neuromedin L , neuropeptide K , neuropeptide gamma , preprotachykinin , protachykinin-1 , substance K , substance P , tachykinin 2 , tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma) , Tachykinin (substance P, neurokinin A, neuropeptide K, neuropeptide gamma) , tachykinin 1 , tachykinin, precursor 1 , delta preprotachykinin I , preprotachykinin A , protachykinin-1 preproprotein , preprotachykinin I , substance P, neuropeptide gamma, neurokinin A , Substance P , tachykinin precursor 1 L homeolog

6863 Homo sapiens
24806 Rattus norvegicus
475239 Canis lupus familiaris
697350 Macaca mulatta
100034669 Ovis aries
100379583 Cavia porcellus
100528498 Ictalurus punctatus
21333 Mus musculus
281512 Bos taurus
420573 Gallus gallus
100009275 Oryctolagus cuniculus
100052324 Equus caballus
735077 Xenopus laevis
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