Taurine Transporter Proteins (TAUT)

Mouse (Murine) Taurine Transporter (TAUT) interaction partners

1. These findings suggest that TauT protein expression is relatively insensitive to changes in muscle taurine content in WT and mdx (show DMD Proteins) mice, and that taurine and beta-alanine supplementation may be viable therapeutic strategies to improve fatigue resistance of dystrophic skeletal muscle.

2. This study evaluated the role of taurine and its transporter on pancreatic islet cells and insulin (show INS Proteins) secretion.

3. both homozygous and heterozygous TauT gene deletion predispose C57BL/6 mice to develop end-stage diabetic kidney disease

4. Studied protective effect of taurine associated with the upregulation of TAUT expression in acute myocardial ischemia. Data showed that taurine reversed the apoptosis induced by hypoxia and AMI (show CFD Proteins), thereby, effectively protecting the myocardium.

5. Acute exposure to ROS (show ROS1 Proteins) reduces taurine uptake as a result of modulated TauT transport kinetics.

6. Effective T-cell recall responses require the taurine transporter Taut.

7. study represents the first characterization of TauT in neural precursor cells

8. data suggest TauT plays a critical role in renal function; expression of TauT is negatively regulated by p53 (show TP53 Proteins) and positively regulated by c-Jun (show JUN Proteins); outcome level of TauT may determine the fate of renal cells during stress-induced acute kidney injury

9. All taut-/- mice succumb to infections during crisis, while about 90% of the control taut(+/+) mice survive.

10. decreased sensitivity of mature erythrocytes from taut-/- mice to osmotic shock and oxidative stress, rendering them more resistant to apoptosis

Cow (Bovine) Taurine Transporter (TAUT) interaction partners

1. Results indicate that the gene expressions of TauT and cyclin C (show CCNC Proteins) are cooperatively regulated under hypotonic conditions.

Human Taurine Transporter (TAUT) interaction partners

1. TauT gene expression is significantly upregulated in mononuclear leukocytes of type 1 diabetes patients and is related to HbA1c levels and inversely to plasma homocysteine.

2. CNDP1 (show CNDP1 Proteins) and CARNS are expressed in glomeruli and tubular cells; TauT is expressed in renal epithelial cells; CDNP1 may have a role in diabetic neuropathy

3. This is the first study to present information on the transcriptional regulation of taurine transporter gene and the localization of the taurine transporter protein (show HNRNPU Proteins) in chondrocytic cells.

4. Neurotransmitter transporters including SLC6A6 and SLC6A13 mediate the uptake of 5-aminolevulinic acid (ALA) and can play roles in the enhancement of ALA-induced accumulation of protoporphyrin in cancerous cells.

5. Immunocytochemistry and flow cytometry analyses revealed that these mAbs recognized the native form of the extracellular domain of SLC6A6 on the cell surface.

6. Syncytiotrophoblast TauT activity is reduced in maternal obesity and pre-eclampsia compared to normal pregnancy.

7. Expression of TauT is differentially regulated by Vitamin D(3) and retinoic acid via formation of VDR and RXR complexes in the nuclei in a cell type-dependent manner.

8. Knockdown of TauT impairs kidney development, possibly through regulation of cell cycle-related genes.

9. TauT gene is overexpressed in peripheral blood mononuclear cells of type 2 diabetic patients.

10. TNF-alpha (show TNF Proteins)-treated cells showed a higher mRNA level of the TAUT (taurine transporter) than did the control cells.