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The protein encoded by TENC1 belongs to the tensin family. Additionally we are shipping and many more products for this protein.
Showing 10 out of 19 products:
Human Polyclonal TENC1 Primary Antibody for IHC, IHC (p) - ABIN4358496
Dieterich, Mellberg, Langenkamp, Zhang, Zieba, Salomäki, Teichert, Huang, Edqvist, Kraus, Augustin, Olofsson, Larsson, Söderberg, Molema, Pontén, Georgii-Hemming, Alafuzoff, Dimberg: Transcriptional profiling of human glioblastoma vessels indicates a key role of VEGF-A and TGFβ2 in vascular abnormalization. in The Journal of pathology 2012
Patients with low TNS2 expression showed poor relapse-free survival rates for breast and lung cancers. These results strongly suggest a role of tensin2 in suppressing cell transformation and reduction of tumorigenicity.
p62 (show GTF2H1 Antibodies) expression increased but C1-Ten protein decreased during muscle differentiation, supporting a role for p62 (show GTF2H1 Antibodies) as a physiological regulator of C1-Ten.
Pulld (show DISC1 Antibodies)own studies in human cells using Myc-tagged Tensin2 constructs revealed that DISC1 specifically interacts with the C-terminal PTB domain of Tensin2 in a phosphorylation-independent manner.
The tumor suppressor DLC1 (show DYNLL1 Antibodies) utilizes a novel binding site for tensin2 PTB (show PTBP1 Antibodies) domain interaction
Results identified tensin2 as a Syk (show SYK Antibodies)-binding protein.
Here, we report complete chemical shift assignments of the SH2 domain of human tensin2 determined by triple resonance experiments.
Tensin2 is an important new mediator in TPO (show THPO Antibodies)/c-Mpl (show MPL Antibodies) pathway and has a positive affect on cellular growth, at least in part through its effect on the PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) signaling.
Tensin2 SH2 domain was identified to interact with nonphosphorylated ligand (DLC-1 (show DYNLL1 Antibodies)) as well as phosphorylated ligand.
Tensin2, in addition to regulating cytoskeletal dynamics, influences phosphoinositide-Akt (show AKT1 Antibodies) signalling through its PTPase domain.
focal adhesion-localized tensin 2 negatively regulates DLC1 (show DYNLL1 Antibodies) to permit Rho-mediated actomyosin contraction and remodeling of collagen fibers
deficiency causes alteration of actin remodeling and morphological changes in podocytes and subsequent proteinuria
Data suggest that Tenc1 (tensin2) contributes to the maintenance of glomerular basement membrane (GBM) structures and that the genetic background influences the severity of nephrotic syndrome.
DISC1 (show DISC1 Antibodies)-Tensin2 colocalisation was most clearly observed in the Purkinje cells of the mouse cerebellum.
C1-Ten is a novel protein tyrosine phosphatase (show ACP1 Antibodies) (PTPase) of IRS-1 (show IRS1 Antibodies) that acts as a mediator to reduce IRS-1 (show IRS1 Antibodies) under a catabolic condition, resulting in muscle atrophy. C1-Ten preferentially dephosphorylated Y612 of IRS-1 (show IRS1 Antibodies), which accelerated IRS-1 (show IRS1 Antibodies) degradation.
These data descrived the importance of concomitant decreases in podocin, CD2AP (show Cd2ap Antibodies) and tensin2 during septic acute renal failure-associated proteinuria.
Results suggest that tensin2 is involved in expression and extension of nephrin (show NPHS1 Antibodies), while tensin2 deficiency may result in proteinuria, associated with the loss of slit integrity.
The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.
C1 domain-containing phosphatase and tensin homolog
, tensin 2
, tensin like C1 domain-containing phosphatase
, tensin-like C1 domain-containing phosphatase
, C1 domain-containing phosphatase and tensin-like protein