anti-Tet Methylcytosine Dioxygenase 2 (TET2) Antibodies

The protein encoded by TET2 is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. Additionally we are shipping TET2 Kits (1) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TET2 54790 Q6N021
TET2 214133 Q4JK59
TET2 310859  
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Top anti-TET2 Antibodies at

Showing 10 out of 135 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated IP, WB Tes2 mAb (Clone 21F11) tested by Immunoprecipitation. Tet2 detection by Immunoprecipitation. Lane 1: Input (25 µg of HL-60 whole cell lysate). Lane 2: Negative control mAb. Lane 3: Tet2 antibody at 1 µg/ml. 250 µg of HL-60 whole cell lysate per IP. Tes2 mAb (Clone 21F11) tested by Western blot. Tet2 detection by Western blot. Lane 1: HL-60 whole cell lysate (40 µg). Lane 2: Lymphoblastoid Tet2 negative (-/-) whole cell lysate (40 µg). Lane 3: Lymphoblastoid Tet2 positive (+/+) whole cell lysate (40 µg). All probed with Tet2 antibody at a 1 µg/ml dilution. 100 μg Log in to see 1 to 2 Days
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), IP, WB Immunohistochemistry: TET2 Antibody  - Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-TET2 used at a dilution of 1:5,000 (0.2ug/ml). Detection: DAB Western Blot: TET2 Antibody  - Whole cell lysate (50 ug) from HeLa, 293T, and Jurkat cells. Antibodies: Affinity purified rabbit anti-TET2 antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds. 0.1 mL Log in to see 7 to 9 Days
Human Goat Un-conjugated IHC, ELISA 0.1 mg Log in to see 2 to 3 Days
Human Rabbit Un-conjugated IHC, WB Immunohistochemistry of paraffin-embedded rat lung using TET2 antibody at dilution of 1:100 (40x lens). 100 μL Log in to see 16 Days
Human Goat Un-conjugated ELISA, IHC, IHC (p)   0.1 mg Log in to see 7 to 9 Days
Dog Goat Un-conjugated EIA, IHC (p)   0.1 mg Log in to see 10 to 12 Days
Human Rabbit Un-conjugated WB TET2 Antibody (N-term)  western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the TET2 antibody detected the TET2 protein (arrow). 400 μL Log in to see 10 to 11 Days
Human Goat Un-conjugated ELISA, WB   0.1 mg Log in to see 2 to 3 Days
Human Rabbit Un-conjugated EIA, WB   0.1 mg Log in to see 12 to 15 Days
Human Rabbit Un-conjugated IP, WB 100 μL Log in to see 16 Days

TET2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-TET2 Antibodies

  1. Human Monoclonal TET2 Primary Antibody for IP, WB - ABIN2668527 : Wallner, Schröder, Leitão, Berulava, Haak, Beißer, Rahmann, Richter, Manke, Bönisch, Arrigoni, Fröhler, Klironomos, Chen, Rajewsky, Müller, Ebert, Lengauer, Barann, Rosenstiel, Gasparoni, Nordström et al.: Epigenetic dynamics of monocyte-to-macrophage differentiation. ... in Epigenetics & chromatin 2016 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal TET2 Primary Antibody for IHC, ELISA - ABIN571057 : Orr, Haffner, Nelson, Yegnasubramanian, Eberhart: Decreased 5-hydroxymethylcytosine is associated with neural progenitor phenotype in normal brain and shorter survival in malignant glioma. in PLoS ONE 2012 (PubMed)

  3. Human Polyclonal TET2 Primary Antibody for ELISA, IHC - ABIN4358584 : Langemeijer, Kuiper, Berends, Knops, Aslanyan, Massop, Stevens-Linders, van Hoogen, van Kessel, Raymakers, Kamping, Verhoef, Verburgh, Hagemeijer, Vandenberghe, de Witte, van der Reijden, Jansen: Acquired mutations in TET2 are common in myelodysplastic syndromes. in Nature genetics 2009 (PubMed)

  4. Human Polyclonal TET2 Primary Antibody for ICC, IF - ABIN4358585 : Fischer, Miles: Silencing HIF-1α induces TET2 expression and augments ascorbic acid induced 5-hydroxymethylation of DNA in human metastatic melanoma cells. in Biochemical and biophysical research communications 2017 (PubMed)

More Antibodies against TET2 Interaction Partners

Human Tet Methylcytosine Dioxygenase 2 (TET2) interaction partners

  1. Patients with mutations 6 showed higher rate of achieving major molecular response than those<6 (P=0.0381). Mutations in epigenetic regulator, ASXL1 (show ASXL1 Antibodies), TET2, TET3 (show TET3 Antibodies), KDM1A (show KDM1A Antibodies) and MSH6 (show MSH6 Antibodies) were found in 25% of patients. TET2 or TET3 (show TET3 Antibodies), AKT1 (show AKT1 Antibodies) and RUNX1 (show RUNX1 Antibodies) were mutated in one patient each. ASXL1 (show ASXL1 Antibodies) was mutated within exon 12 in three cases

  2. TET2, ASXL1 (show ASXL1 Antibodies), IDH1 (show IDH1 Antibodies), and IDH2 (show IDH2 Antibodies) Single Nucleotide Polymorphisms in Turkish Patients with Chronic Myeloproliferative Neoplasms.

  3. Here we report that retinoic acid (RA) or retinol (vitamin A) and ascorbate (vitamin C) act as modulators of TET levels and activity. RA or retinol enhances 5hmC production in naive embryonic stem cells by activation of TET2 and TET3 (show TET3 Antibodies) transcription, whereas ascorbate potentiates TET activity and 5hmC production through enhanced Fe(2+) recycling, and not as a cofactor as reported previously

  4. identified a novel case of a donor-derived myelodysplastic syndrome in an HSCT recipient that is consistent with clonal evolution of TET2-mutated clonal hematopoiesis of indeterminate potential (CHIP)

  5. TET2 in African Americans was associated with aggressive prostate cancer, with 24.4% of cases harboring a rare deleterious variant compared with 9.6% of controls

  6. Therefore, chemical hypoxia not only causes overexpression of TET1 (show TET1 Antibodies) and TET2 but also could gradually do promoter demethylation of same genes

  7. Overexpression of the wild-type TET1 (show TET1 Antibodies)/2/3 3'UTR (show UTS2R Antibodies) caused a significant increase in EZH2 (show EZH2 Antibodies) expression and tumor growth, whereas the mutation in miR (show MLXIP Antibodies)-26-binding sites abolished this effect.

  8. Tet methylcytosine dioxygenase 2 (TET2) mutations can be detected in human MPhis cultured from MDS/CMML patient samples.

  9. Concurrent STAT3 (show STAT3 Antibodies), DNMT3A (show DNMT3A Antibodies), and TET2 mutations in T-LGL leukemia with molecularly distinct clonal hematopoiesis of indeterminate potential

  10. Multivariate analysis showed that KIT-AL and TET2 mutations were associated with inferior LFS, whereas age 40 years and marrow blast 70% were associated with inferior OS.

Mouse (Murine) Tet Methylcytosine Dioxygenase 2 (TET2) interaction partners

  1. TET2 requires its catalytic activity in hematopoietic stem/progenitor cells to exert its myeloid malignancy-suppressive function

  2. this article demonstrates that TET2 regulates CD8 (show CD8A Antibodies)+ T cell differentiation

  3. TET proteins, particularly TET2, were required for adipogenesis by modulating DNA methylation (show HELLS Antibodies) at the Ppargamma (show PPARG Antibodies) locus, subsequently by inducing Ppargamma (show PPARG Antibodies) gene expression.

  4. Tet methylcytosine dioxygenase 2 (TET2) was the most highly expressed Tet enzyme in murine macrophage (MPhi) differentiation.

  5. Here the authors show that concomitant loss of Tet2 and Tet3 (show TET3 Antibodies) in mice at early B cell stage blocked the pro- to pre-B cell transition in the bone marrow, decreased Irf4 (show IRF4 Antibodies) expression and impaired the germline transcription and rearrangement of the Igkappa locus.

  6. in the absence of TET2, mast cell differentiation is under the control of compensatory mechanisms mediated by other TET family members, while proliferation is strictly dependent on TET2 expression.

  7. ablation of Tet2 in myeloid cells suppresses melanoma growth in vivo and shifted the immunosuppressive gene expression program in tumor-associated macrophages to a proinflammatory one

  8. These results support the hypothesis that somatic TET2 mutations in blood cells play a causal role in atherosclerosis.

  9. Loss of TET2 expression is associated with development of malignancy.

  10. confirm the transformation potential of DNMT3A (show DNMT3A Antibodies)(R882H) Tet2(-/-) progenitors and represent the first cooperative model in mice involving Tet2 inactivation driving lymphoid malignancies

TET2 Antigen Profile

Protein Summary

The protein encoded by this gene is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. The encoded protein is involved in myelopoiesis, and defects in this gene have been associated with several myeloproliferative disorders. Two variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with TET2

  • tet methylcytosine dioxygenase 2 (TET2) antibody
  • tet methylcytosine dioxygenase 2 (Tet2) antibody
  • Ayu17-449 antibody
  • E130014J05Rik antibody
  • KIAA1546 antibody
  • MDS antibody
  • mKIAA1546 antibody
  • RGD1311625 antibody

Protein level used designations for TET2

methylcytosine dioxygenase TET2 , probable methylcytosine dioxygenase TET2 , tet oncogene family member 2 , tet oncogene 2

54790 Homo sapiens
478499 Canis lupus familiaris
214133 Mus musculus
310859 Rattus norvegicus
422540 Gallus gallus
100521465 Sus scrofa
538481 Bos taurus
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