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The protein encoded by TET2 is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. Additionally we are shipping TET2 Kits (1) and many more products for this protein.
Showing 10 out of 136 products:
Human Monoclonal TET2 Primary Antibody for IP, WB - ABIN2668527
Wallner, Schröder, Leitão, Berulava, Haak, Beißer, Rahmann, Richter, Manke, Bönisch, Arrigoni, Fröhler, Klironomos, Chen, Rajewsky, Müller, Ebert, Lengauer, Barann, Rosenstiel, Gasparoni, Nordström et al.: Epigenetic dynamics of monocyte-to-macrophage differentiation. ... in Epigenetics & chromatin 2016
Show all 2 Pubmed References
Human Polyclonal TET2 Primary Antibody for IHC, ELISA - ABIN571057
Orr, Haffner, Nelson, Yegnasubramanian, Eberhart: Decreased 5-hydroxymethylcytosine is associated with neural progenitor phenotype in normal brain and shorter survival in malignant glioma. in PLoS ONE 2012
Human Polyclonal TET2 Primary Antibody for ELISA, IHC - ABIN4358584
Langemeijer, Kuiper, Berends, Knops, Aslanyan, Massop, Stevens-Linders, van Hoogen, van Kessel, Raymakers, Kamping, Verhoef, Verburgh, Hagemeijer, Vandenberghe, de Witte, van der Reijden, Jansen: Acquired mutations in TET2 are common in myelodysplastic syndromes. in Nature genetics 2009
Human Polyclonal TET2 Primary Antibody for ICC, IF - ABIN4358585
Fischer, Miles: Silencing HIF-1α induces TET2 expression and augments ascorbic acid induced 5-hydroxymethylation of DNA in human metastatic melanoma cells. in Biochemical and biophysical research communications 2017
Data suggest that deregulated expression of TET2 by DNA hypermethylation may contribute to the aberrantly low level of 5hmC in parathyroid carcinoma and further that TET2 plays a cell growth and cell migratory regulatory role and may constitute a parathyroid tumor suppressor gene.
This result suggests that TET2(P1962T) mutation in association with germline RUNX1 (show RUNX1 Antibodies)(R174Q) mutation leads to amplification of a haematopoietic clone susceptible to acquire other transforming alterations
DNMT3A (show DNMT3A Antibodies) senses the TGF-beta (show TGFB1 Antibodies) signal and silences TET2 and TET3 (show TET3 Antibodies) promoters to induce the epithelial-mesenchymal transition-like process and metastasis in melanoma.
TET2 functions as a resistance factor against DNA methylation (show HELLS Antibodies) in gastric epithelial cells and repression of TET2 contributes to DNA methylation (show HELLS Antibodies) acquisition during Epstein Barr virus infection.
Patients with mutations 6 showed higher rate of achieving major molecular response than those<6 (P=0.0381). Mutations in epigenetic regulator, ASXL1 (show ASXL1 Antibodies), TET2, TET3 (show TET3 Antibodies), KDM1A (show KDM1A Antibodies) and MSH6 (show MSH6 Antibodies) were found in 25% of patients. TET2 or TET3 (show TET3 Antibodies), AKT1 (show AKT1 Antibodies) and RUNX1 (show RUNX1 Antibodies) were mutated in one patient each. ASXL1 (show ASXL1 Antibodies) was mutated within exon 12 in three cases
TET2, ASXL1 (show ASXL1 Antibodies), IDH1 (show IDH1 Antibodies), and IDH2 (show IDH2 Antibodies) Single Nucleotide Polymorphisms in Turkish Patients with Chronic Myeloproliferative Neoplasms.
Here we report that retinoic acid (RA) or retinol (vitamin A) and ascorbate (vitamin C) act as modulators of TET levels and activity. RA or retinol enhances 5hmC production in naive embryonic stem cells by activation of TET2 and TET3 (show TET3 Antibodies) transcription, whereas ascorbate potentiates TET activity and 5hmC production through enhanced Fe(2+) recycling, and not as a cofactor as reported previously
identified a novel case of a donor-derived myelodysplastic syndrome in an HSCT recipient that is consistent with clonal evolution of TET2-mutated clonal hematopoiesis of indeterminate potential (CHIP)
TET2 in African Americans was associated with aggressive prostate cancer, with 24.4% of cases harboring a rare deleterious variant compared with 9.6% of controls
Therefore, chemical hypoxia not only causes overexpression of TET1 (show TET1 Antibodies) and TET2 but also could gradually do promoter demethylation of same genes
TET2 has the effect of inhibiting LPS (show TLR4 Antibodies)-induced macrophage activation and plays an inhibitory role in macrophage M1 and M2 polarization.
Tet1 (show TET1 Antibodies)/2/3 proteins have a key role in modulating Wnt (show WNT2 Antibodies) signaling and establishing the proper balance between neural and mesodermal cell fate determination in mouse embryos and embryonic stem cells
TET1 (show TET1 Antibodies) and TET2 play an important role in the proliferation of neural stem cells in the adult mouse brain.
we identified that TET2 was downregulated during the pathogenesis of atherosclerosis. The downregulation of TET2 promotes the methylation of the Beclin 1 (show BECN1 Antibodies) promoter, leading to endothelial cell autophagy, impaired autophagic flux, and inflammatory factor upregulation.
These findings suggest that the catalytic and scaffolding activities of TDG (show TDG Antibodies) are essential for retinoic acid-dependent gene expression and provide important insights into the mechanisms underlying targeting of TET-TDG (show TDG Antibodies) complexes.
TET2 requires its catalytic activity in hematopoietic stem/progenitor cells to exert its myeloid malignancy-suppressive function
this article demonstrates that TET2 regulates CD8 (show CD8A Antibodies)+ T cell differentiation
TET proteins, particularly TET2, were required for adipogenesis by modulating DNA methylation (show HELLS Antibodies) at the Ppargamma (show PPARG Antibodies) locus, subsequently by inducing Ppargamma (show PPARG Antibodies) gene expression.
Tet methylcytosine dioxygenase 2 (TET2) was the most highly expressed Tet enzyme in murine macrophage (MPhi) differentiation.
Here the authors show that concomitant loss of Tet2 and Tet3 (show TET3 Antibodies) in mice at early B cell stage blocked the pro- to pre-B cell transition in the bone marrow, decreased Irf4 (show IRF4 Antibodies) expression and impaired the germline transcription and rearrangement of the Igkappa locus.
The protein encoded by this gene is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. The encoded protein is involved in myelopoiesis, and defects in this gene have been associated with several myeloproliferative disorders. Two variants encoding different isoforms have been found for this gene.
methylcytosine dioxygenase TET2
, probable methylcytosine dioxygenase TET2
, tet oncogene family member 2
, tet oncogene 2