anti-Tet Methylcytosine Dioxygenase 2 (TET2) Antibodies

The protein encoded by TET2 is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. Additionally we are shipping TET2 Kits (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TET2 54790 Q6N021
TET2 214133 Q4JK59
TET2 310859  
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top anti-TET2 Antibodies at antibodies-online.com

Showing 10 out of 143 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated IP, WB Tes2 mAb (Clone 21F11) tested by Immunoprecipitation. Tet2 detection by Immunoprecipitation. Lane 1: Input (25 µg of HL-60 whole cell lysate). Lane 2: Negative control mAb. Lane 3: Tet2 antibody at 1 µg/ml. 250 µg of HL-60 whole cell lysate per IP. Tes2 mAb (Clone 21F11) tested by Western blot. Tet2 detection by Western blot. Lane 1: HL-60 whole cell lysate (40 µg). Lane 2: Lymphoblastoid Tet2 negative (-/-) whole cell lysate (40 µg). Lane 3: Lymphoblastoid Tet2 positive (+/+) whole cell lysate (40 µg). All probed with Tet2 antibody at a 1 µg/ml dilution. 100 μg Log in to see 1 to 2 Days
$495.83
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), IP, WB Immunohistochemistry: TET2 Antibody  - Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-TET2 used at a dilution of 1:5,000 (0.2ug/ml). Detection: DAB Western Blot: TET2 Antibody  - Whole cell lysate (50 ug) from HeLa, 293T, and Jurkat cells. Antibodies: Affinity purified rabbit anti-TET2 antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds. 0.1 mL Log in to see 7 to 9 Days
$556.31
Details
Human Goat Un-conjugated IHC, ELISA 0.1 mg Log in to see 2 to 3 Days
$481.25
Details
Human Rabbit Un-conjugated IHC, WB Immunohistochemistry of paraffin-embedded rat lung using TET2 antibody at dilution of 1:100 (40x lens). 100 μL Log in to see 16 Days
$334.02
Details
Human Goat Un-conjugated ELISA, IHC, IHC (p)   0.1 mg Log in to see 7 to 9 Days
$485.88
Details
Human Rabbit Un-conjugated IHC, WB Western blot analysis of extracts of A-431 cells, using TET2 antibody (ABIN5973320) at 1/1000 dilution. Immunohistochemistry of paraffin-embedded rat lung using TET2 antibody (ABIN5973320) at dilution of 1/100 (40x lens). 100 μL Log in to see 11 to 16 Days
$426.40
Details
Dog Goat Un-conjugated EIA, IHC (p)   0.1 mg Log in to see Available
$462.00
Details
Human Rabbit Un-conjugated WB TET2 Antibody (N-term)  western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the TET2 antibody detected the TET2 protein (arrow). 400 μL Log in to see 10 to 11 Days
$335.50
Details
Human Goat Un-conjugated ELISA, WB   0.1 mg Log in to see 2 to 3 Days
$446.88
Details
Human Rabbit Un-conjugated EIA, WB   0.1 mg Log in to see 8 to 11 Days
$474.10
Details

Top referenced anti-TET2 Antibodies

  1. Human Monoclonal TET2 Primary Antibody for IP, WB - ABIN2668527 : Wallner, Schröder, Leitão, Berulava, Haak, Beißer, Rahmann, Richter, Manke, Bönisch, Arrigoni, Fröhler, Klironomos, Chen, Rajewsky, Müller, Ebert, Lengauer, Barann, Rosenstiel, Gasparoni, Nordström et al.: Epigenetic dynamics of monocyte-to-macrophage differentiation. ... in Epigenetics & chromatin 2016 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal TET2 Primary Antibody for IHC, ELISA - ABIN571057 : Orr, Haffner, Nelson, Yegnasubramanian, Eberhart: Decreased 5-hydroxymethylcytosine is associated with neural progenitor phenotype in normal brain and shorter survival in malignant glioma. in PLoS ONE 2012 (PubMed)

  3. Human Polyclonal TET2 Primary Antibody for ICC, IF - ABIN4358585 : Fischer, Miles: Silencing HIF-1α induces TET2 expression and augments ascorbic acid induced 5-hydroxymethylation of DNA in human metastatic melanoma cells. in Biochemical and biophysical research communications 2017 (PubMed)

  4. Human Polyclonal TET2 Primary Antibody for ELISA, IHC - ABIN4358584 : Langemeijer, Kuiper, Berends, Knops, Aslanyan, Massop, Stevens-Linders, van Hoogen, van Kessel, Raymakers, Kamping, Verhoef, Verburgh, Hagemeijer, Vandenberghe, de Witte, van der Reijden, Jansen: Acquired mutations in TET2 are common in myelodysplastic syndromes. in Nature genetics 2009 (PubMed)

More Antibodies against TET2 Interaction Partners

Human Tet Methylcytosine Dioxygenase 2 (TET2) interaction partners

  1. TET2 plays an important role in the pathogenesis of diabetic nephropathy by activating TGFbeta1 (show TGFB1 Antibodies) expression through demethylation of CpG islands in the TGFbeta1 (show TGFB1 Antibodies) regulatory region

  2. Studies indicate that TET methylcytosine dioxygenase 2 (TET2) plays an important role in preventing atherosclerosis by repressing vascular smooth muscle cell (VSMC) phenotype transformation, protecting endothelial cells (ECs) from damage and dysfunction, and inhibiting inflammation [Review].

  3. The results of the present study demonstrated that the genes cryptochrome circadian clock 1, zinc finger protein (ZNF (show ZNF629 Antibodies)) interacting with K protein 1, ZNF134 (show ZNF134 Antibodies), ZNF256 (show ZNF256 Antibodies) and ZNF615, which were hypermethylated and downregulated in Diffuse large B-cell lymphoma (DLBCL) patients with TET2 mutations, were the key genes in the association between DLBCL and TET mutations.

  4. Data suggest that deregulated expression of TET2 by DNA hypermethylation may contribute to the aberrantly low level of 5hmC in parathyroid carcinoma and further that TET2 plays a cell growth and cell migratory regulatory role and may constitute a parathyroid tumor suppressor gene.

  5. This result suggests that TET2(P1962T) mutation in association with germline RUNX1 (show RUNX1 Antibodies)(R174Q) mutation leads to amplification of a haematopoietic clone susceptible to acquire other transforming alterations

  6. DNMT3A (show DNMT3A Antibodies) senses the TGF-beta (show TGFB1 Antibodies) signal and silences TET2 and TET3 (show TET3 Antibodies) promoters to induce the epithelial-mesenchymal transition-like process and metastasis in melanoma.

  7. TET2 functions as a resistance factor against DNA methylation (show HELLS Antibodies) in gastric epithelial cells and repression of TET2 contributes to DNA methylation (show HELLS Antibodies) acquisition during Epstein Barr virus infection.

  8. Patients with mutations 6 showed higher rate of achieving major molecular response than those<6 (P=0.0381). Mutations in epigenetic regulator, ASXL1 (show ASXL1 Antibodies), TET2, TET3 (show TET3 Antibodies), KDM1A (show KDM1A Antibodies) and MSH6 (show MSH6 Antibodies) were found in 25% of patients. TET2 or TET3 (show TET3 Antibodies), AKT1 (show AKT1 Antibodies) and RUNX1 (show RUNX1 Antibodies) were mutated in one patient each. ASXL1 (show ASXL1 Antibodies) was mutated within exon 12 in three cases

  9. TET2, ASXL1 (show ASXL1 Antibodies), IDH1 (show IDH1 Antibodies), and IDH2 (show IDH2 Antibodies) Single Nucleotide Polymorphisms in Turkish Patients with Chronic Myeloproliferative Neoplasms.

  10. Here we report that retinoic acid (RA) or retinol (vitamin A) and ascorbate (vitamin C) act as modulators of TET levels and activity. RA or retinol enhances 5hmC production in naive embryonic stem cells by activation of TET2 and TET3 (show TET3 Antibodies) transcription, whereas ascorbate potentiates TET activity and 5hmC production through enhanced Fe(2+) recycling, and not as a cofactor as reported previously

Mouse (Murine) Tet Methylcytosine Dioxygenase 2 (TET2) interaction partners

  1. TET2 plays an important role in the pathogenesis of diabetic nephropathy by activating TGFbeta1 (show TGFB1 Antibodies) expression through demethylation of CpG islands in the TGFbeta1 (show TGFB1 Antibodies) regulatory region

  2. Results demonstrate a novel and unexpected role for SETDB1 (show SETDB1 Antibodies) in protecting IAPs from TET2-dependent histone arginine demethylation.

  3. study reveals a previously unknown regulatory role of Tet2 at the epitranscriptomic level, promoting myelopoiesis during infection in the mammalian system by decreasing 5-mCs (show SMCP Antibodies) in mRNAs; moreover, the inhibitory function of cytosine methylation on double-stranded RNA formation and Adar1 (show ADAR Antibodies) binding in mRNA reveals its new physiological role in the mammalian system

  4. This work revealed a critical role of TET2-mediated DNA demethylation against oxidative stress, and provided the molecular mechanisms underlying the epigenetic regulation of iron homeostasis in response to stress erythropoiesis.

  5. TET2 has the effect of inhibiting LPS (show TLR4 Antibodies)-induced macrophage activation and plays an inhibitory role in macrophage M1 and M2 polarization.

  6. Tet1 (show TET1 Antibodies)/2/3 proteins have a key role in modulating Wnt (show WNT2 Antibodies) signaling and establishing the proper balance between neural and mesodermal cell fate determination in mouse embryos and embryonic stem cells

  7. TET1 (show TET1 Antibodies) and TET2 play an important role in the proliferation of neural stem cells in the adult mouse brain.

  8. we identified that TET2 was downregulated during the pathogenesis of atherosclerosis. The downregulation of TET2 promotes the methylation of the Beclin 1 (show BECN1 Antibodies) promoter, leading to endothelial cell autophagy, impaired autophagic flux, and inflammatory factor upregulation.

  9. These findings suggest that the catalytic and scaffolding activities of TDG (show TDG Antibodies) are essential for retinoic acid-dependent gene expression and provide important insights into the mechanisms underlying targeting of TET-TDG (show TDG Antibodies) complexes.

  10. TET2 requires its catalytic activity in hematopoietic stem/progenitor cells to exert its myeloid malignancy-suppressive function

TET2 Antigen Profile

Protein Summary

The protein encoded by this gene is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. The encoded protein is involved in myelopoiesis, and defects in this gene have been associated with several myeloproliferative disorders. Two variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with TET2

  • tet methylcytosine dioxygenase 2 (TET2) antibody
  • tet methylcytosine dioxygenase 2 (Tet2) antibody
  • Ayu17-449 antibody
  • E130014J05Rik antibody
  • KIAA1546 antibody
  • MDS antibody
  • mKIAA1546 antibody
  • RGD1311625 antibody

Protein level used designations for TET2

methylcytosine dioxygenase TET2 , probable methylcytosine dioxygenase TET2 , tet oncogene family member 2 , tet oncogene 2

GENE ID SPECIES
54790 Homo sapiens
478499 Canis lupus familiaris
214133 Mus musculus
310859 Rattus norvegicus
422540 Gallus gallus
100521465 Sus scrofa
538481 Bos taurus
Selected quality suppliers for anti-TET2 (TET2) Antibodies
Did you look for something else?