Thiamine Biosynthesis1 Proteins

Protein Summary

Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance.

Gene names and symbols associated with Thiamine Biosynthesis1 Proteins (THI1)

• thiamine biosynthesis 1 (thi1) antibody

• thi1-1 antibody

Protein level used designations for Thiamine Biosynthesis1 Proteins (THI1)

QCB2h02 , Sed2 , gnp_QCB2h02 , gpm589 , iger2b(thi) , pcPOG1 , thiamine biosynthetic enzyme , thiamine thiazole synthase 1, chloroplastic , thiazole biosynthetic enzyme 1 , thiazole biosynthetic enzyme 1-1, chloroplastic , uiu(pog1C) , uiu1c(pog) , uiu4 , uiu4(pog1c)