Thyroid Hormone Receptor Interactor 13 Proteins (TRIP13)

TRIP13 encodes a protein that interacts with thyroid hormone receptors, also known as hormone-dependent transcription factors. Additionally we are shipping TRIP13 Antibodies (75) and TRIP13 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TRIP13 9319 Q15645
TRIP13 69716 Q3UA06
TRIP13 292206 Q5XHZ9
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Top TRIP13 Proteins at antibodies-online.com

Showing 8 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
$9,626.73
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
$9,626.73
Details
Wheat germ Human GST tag 10 μg 11 to 12 Days
$414.29
Details
Yeast Wild boar His tag   1 mg 60 to 71 Days
$3,202.83
Details
Yeast Chicken His tag   1 mg 60 to 71 Days
$3,206.50
Details
Yeast Dog His tag   1 mg 60 to 71 Days
$3,206.50
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Yeast Rat His tag   1 mg 60 to 71 Days
$3,206.50
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Yeast Xenopus tropicalis His tag   1 mg 60 to 71 Days
$3,206.50
Details

TRIP13 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for Thyroid Hormone Receptor Interactor 13 (TRIP13) Interaction Partners

Human Thyroid Hormone Receptor Interactor 13 (TRIP13) interaction partners

  1. miR-515-5p is down-regulated, and associated with the malignant status and prognosis in prostate cancer patients. MiR-515-5p acts as a tumor suppressor to regulate cell proliferation, migration and invasion via targeting TRIP13 in prostate cancer.

  2. TRIP13 replenishes the O-MAD2 pool for activation by unattached kinetochores.

  3. TRIP13 mRNA significantly over-expressed in chronic lymphocytic leukemia patients CD19(+) B lymphocytes

  4. TRIP13 is correlated with clinical progression and poor prognosis

  5. study provides insights into how specific substrates are recruited to AAA+ ATPases (like TRIP13) through adaptor proteins and suggests a model of how translocation through the axial pore of AAA+ ATPases is coupled to protein remodelling

  6. Study revealed that the expression of TRIP13 was elevated in hepatocellular carcinoma (HCC). Furthermore, TRIP3 expression was correlated with cancer progression and malignancy. HCC patients with higher TRIP13 expression had significantly shorter survival periods compared with patients with lower TRIP13 expression.

  7. heightened TRIP13 expression appears to promote lung adenocarcinoma tumor progression.

  8. TRIP13-p31(comet) intercepts and disassembles free mitotic checkpoint complex not bound to anaphase-promoting complex/cyclosome through mediating the local unfolding of the Mad2 C-terminal region.

  9. Microarray analyses indicated that the biological function of TRIP13 in CLL is majorly cell apoptosis and cell proliferation associated. TRIP13 siRNA expressing cells exhibited a slower cell proliferation rate and underwent apoptosis compared with control cells.

  10. TRIP13 ubiquitinates and degrades the checkpoint surveillance protein MAD2 via activating Akt signaling pathway, leading to weakened checkpoint surveillance and consequent tumorigenic aneuploidy and drug resistance in MM.

  11. These results identify an unexpected dependency on TRIP13 in cells overexpressing Mad2.

  12. 6 individuals with biallelic loss-of-function mutations in TRIP13 developed Wilms tumors. TRIP13-mutant patient cells have no detectable TRIP13 and have substantial impairment of the spindle assembly checkpoint (SAC), leading to a high rate of chromosome missegregation. Individuals with biallelic TRIP13 mutations have a high risk of embryonal tumors. These experiments show that their cells display severe SAC impairment.

  13. Thes authors show that p31(comet) binding to the TRIP13 N-terminal domain positions the disordered MAD2 N-terminus for engagement by the TRIP13 "pore loops", which then unfold MAD2 in the presence of ATP.

  14. These results establish a paradigm of the roles of p31(comet) and TRIP13 in both checkpoint activation and inactivation.

  15. the oligomeric form of TRIP13 binds both p31(comet) and MCC

  16. TRIP13 promotes error-prone non-homologous end joining and induces chemoresistance in head and neck cancer.

  17. suggest that premature mitotic checkpoint silencing triggered by TRIP13 overexpression may promote cancer development

  18. propose that TRIP13 plays centrally important roles in the sequence of events leading to MCC disassembly and checkpoint inactivation

Mouse (Murine) Thyroid Hormone Receptor Interactor 13 (TRIP13) interaction partners

  1. In all, these studies suggest that insufficient TRIP13 increased the susceptibility of damaged tubular epithelial cells to progress towards apoptotic cell death.

  2. TRIP13 ubiquitinates and degrades the checkpoint surveillance protein MAD2 via activating Akt signaling pathway, leading to weakened checkpoint surveillance and consequent tumorigenic aneuploidy and drug resistance in MM.

  3. TRIP13-deficient spermatocytes also progress to an H1t-positive stage if ATM activity is attenuated by hypomorphic mutations in Mre11 or Nbs1 or by elimination of the ATM-effector kinase CHK2

  4. TRIP13 promotes error-prone non-homologous end joining and induces chemoresistance in head and neck cancer.

  5. TRIP13 is required for recombination and normal higher-order chromosome structure during meiosis.

  6. HORMAD1 and HORMAD2 are depleted from synapsed chromosome axes with the help of TRIP13.

  7. results demonstrate that in mice, the primary meiotic function of TRIP13 is in recombination itself

TRIP13 Protein Profile

Protein Summary

This gene encodes a protein that interacts with thyroid hormone receptors, also known as hormone-dependent transcription factors. The gene product interacts specifically with the ligand binding domain. This gene is one of several that may play a role in early-stage non-small cell lung cancer.

Gene names and symbols associated with TRIP13

  • thyroid hormone receptor interactor 13 (trip13)
  • thyroid hormone receptor interactor 13 (TRIP13)
  • pachytene checkpoint protein 2 homolog (LOC742208)
  • thyroid hormone receptor interactor 13 (CMU_027690)
  • thyroid hormone receptor interactor 13 (MCYG_05496)
  • pachytene checkpoint protein 2 homolog pseudogene (LOC100348391)
  • thyroid hormone receptor interactor 13 L homeolog (trip13.L)
  • thyroid hormone receptor interactor 13 (Trip13)
  • 16E1BP protein
  • 2410002G23Rik protein
  • D13Ertd328e protein
  • im:6901078 protein
  • PCH2 protein
  • TRIP-13 protein
  • TRIP13 protein
  • zgc:65952 protein

Protein level used designations for TRIP13

TR-interacting protein 13 homolog , TRIP-13 homolog , pachytene checkpoint protein 2 homolog , thyroid hormone receptor interactor 13 homolog , thyroid receptor-interacting protein 13 homolog , Thyroid hormone receptor interactor 13 homolog , Thyroid receptor-interacting protein 13 homolog , thyroid hormone receptor interactor 13 , thyroid receptor-interacting protein 13-like , 16E1-BP , HPV16 E1 protein binding protein , HPV16 E1 protein-binding protein , TR-interacting protein 13 , TRIP-13 , human papillomavirus type 16 E1 protein-binding protein , thyroid receptor interacting protein 13 , thyroid receptor-interacting protein 13 , Pachytene checkpoint protein 2 homolog , Thyroid receptor-interacting protein 13

GENE ID SPECIES
393554 Danio rerio
394836 Xenopus (Silurana) tropicalis
506746 Bos taurus
742208 Pan troglodytes
6994887 Cryptosporidium muris RN66
9224633 Arthroderma otae CBS 113480
100348391 Oryctolagus cuniculus
100396126 Callithrix jacchus
100461721 Pongo abelii
100545315 Meleagris gallopavo
100552663 Anolis carolinensis
100596508 Nomascus leucogenys
100037172 Xenopus laevis
420798 Gallus gallus
9319 Homo sapiens
609426 Canis lupus familiaris
100337674 Sus scrofa
69716 Mus musculus
292206 Rattus norvegicus
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