anti-Tight Junction Protein 2 (Zona Occludens 2) (TJP2) Antibodies

TJP2 encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. Additionally we are shipping TJP2 Kits (7) and TJP2 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TJP2 9414 Q9UDY2
TJP2 21873 Q9Z0U1
TJP2 115769  
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Top anti-TJP2 Antibodies at antibodies-online.com

Showing 10 out of 111 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Dog Rabbit Un-conjugated WB WB Suggested Anti-TJP2 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:1562500  Positive Control:  MCF7 cell lysate TJP2 is supported by BioGPS gene expression data to be expressed in MCF7 WB Suggested Anti-TJP2  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500  Positive Control: MCF7 cell lysate  TJP2 is supported by BioGPS gene expression data to be expressed in MCF7 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-TJP2 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
$319.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Western Blot: Tight Junction Protein 2 Antibody  - Analysis in human cell line A-431. Western Blot: Tight Junction Protein 2 Antibody  - Primary mouse lung endothelial cells treated with or without control IgG was blotted with the anti-TJP-2 antibody. Primary Antibody diluted 1:1000. This image was submitted via customer Review. 0.1 mL Log in to see 10 to 13 Days
$494.38
Details
Human Rabbit Un-conjugated WB WB Image Sample (30 ug of whole cell lysate) A: U87-MG 5% SDS PAGE antibody diluted at 1:500 100 μL Log in to see 3 to 4 Days
$466.18
Details
Human Rabbit Un-conjugated IHC, WB Western blot analysis of extracts of various cell lines, using TJP2 antibody (ABIN5970222) at 1/1000 dilution. Immunohistochemistry of paraffin-embedded rat spleen using TJP2 antibody (ABIN5970222) at dilution of 1/100 (40x lens). 100 μL Log in to see 11 to 16 Days
$412.19
Details
Human Rabbit Un-conjugated DB Dot blot analysis of Phospho-PTEN-Y240 Antibody Phospho-specific Pab  on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml. 400 μL Log in to see 10 to 11 Days
$385.00
Details
Mouse Rabbit Un-conjugated IHC (p), WB Anti-TJP2 antibody, IHC(P) IHC(P): Mouse Liver Tissue Anti-TJP2 antibody, Western blotting Lane 1: Rat Brain Tissue Lysate Lane 2: PC-12 Cell Lysate Lane 3: Mouse Brain Tissue Lysate Lane 4: HEPA Cell Lysate 100 μg Log in to see 4 to 6 Days
$280.00
Details
Dog Rabbit Un-conjugated IF, IHC, IHC (p), WB Human Placenta, Intermediate Trophoblasts (formalin-fixed, paraffin-embedded) stained with TJP2 antibody ABIN305886 at 5-10 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Anti-TJP2 / ZO-2 antibody IHC of human placenta, intermediate trophoblasts. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. 50 μg Log in to see 11 to 14 Days
$727.83
Details
Human Rabbit Un-conjugated WB TJP2 Antibody (C-term)  western blot analysis in U937 cell line lysates (35ug/lane).This demonstrates the TJP2 antibody detected the TJP2 protein (arrow). 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of ZO-2 using Jurkat whole cell lysates 100 μL Log in to see 11 to 12 Days
$390.77
Details

Top referenced anti-TJP2 Antibodies

  1. Human Polyclonal TJP2 Primary Antibody for ICC, IF - ABIN4359740 : González-Andrades, Garzón, Gascón, Muñoz-Avila, Sánchez-Quevedo, Campos, Alaminos: Sequential development of intercellular junctions in bioengineered human corneas. in Journal of tissue engineering and regenerative medicine 2009 (PubMed)
    Show all 4 Pubmed References

More Antibodies against TJP2 Interaction Partners

Human Tight Junction Protein 2 (Zona Occludens 2) (TJP2) interaction partners

  1. Biochemistry and microscopy approaches in T cells confirmed SNX27/ZO-2 PDZ-dependent interaction, and demonstrated its role controlling the dynamic localization of ZO-2 at the IS

  2. A likely causal mutation was identified in the majority (61%), spanning many genes including ones that have only rarely been reported to cause cholestatic liver disease, e.g. TJP2 and VIPAS39

  3. Patients with a confirmed ABCB11 or tight junction protein 2 gene mutation (n = 7) had a minimally detectable THBA proportion (0.23-2.99% of total BAs). Three patients with an ATP8B1 mutation had an elevated THBA proportion (7.51-37.26%).

  4. Studies indicate the modular and supramodular organization of zonula occludens protein 2 (ZO-2) that allows it to interact with a wide variety of molecules, including cell-cell adhesion proteins, cytoskeletal components, and nuclear factors.

  5. Data identified two Disease-causing Genes TJP2 and GJB2 in a Chinese Family with Unconditional Autosomal Dominant Nonsyndromic Hereditary Hearing Impairment.

  6. TJP2 deficiency may predispose to hepatocellular carcinoma in early childhood

  7. Claudin-19, the most abundant claudin in myelin, exhibited no binding to ZO2.

  8. JAM-A regulates epithelial permeability via association with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and control contraction of the apical cytoskeleton.

  9. Protein-truncating mutations in the tight junction protein 2 gene cause failure of protein localization and disruption of tight-junction structure, leading to severe cholestatic liver disease.

  10. demonstrated that ZO-2 inhibition increases invasive and migrative capacities of invasive tumor cells. This was associated with an increase of MT1-MMP

  11. the Alu-related transcript of TJP2 gene (TJP2-Alu transcript) was differentially expressed between colorectal tumor and normal tissues; potential diagnostic markers for colorectal cancer.

  12. ZO-2 inhibits the Wnt signaling pathway, reduces cell proliferation, and promotes apoptosis; its absence, mutation, or overexpression is present in various human diseases, including deafness and cancer.

  13. AmotL1 and ZO-2 are two candidates that could be harnessed to control the oncogenic function of YAP.

  14. these findings imply involvement of the ZO-2 tight junction independent signaling complex containing Jak1 and uPAR in VSMC intercellular communications.

  15. ZO-2 interacts with YAP2 to form complex; ZO-2 facilitates both nuclear translocation of YAP2 & pro-apoptotic function of YAP2; YAP2/ZO-2 complex appears to be involved in cell detachment

  16. The identification of ZASP helps to unfold the complex nuclear molecular arrays that form on ZO-2 scaffolds.

  17. the first PDZ domain of zona occludens-1 (ZO-1) and 2 (ZO-2) interacts with the carboxy-terminal PDZ binding motif of TAZ

  18. TJP2- and GSK-3beta-mediated increased susceptibility to apoptosis of cells of the inner ear is the mechanism for adult-onset hearing loss in this kindred and may serve as one model for age-related hearing loss in the general population.

  19. Study shows that ZO isoforms bind PtdInsPs and offers an alternative regulatory mechanism for the formation and stabilisation of protein complexes in the nucleus.

  20. Familial hypercholanemia in Amish individuals is associated with mutations in tight junction protein 2 (encoded by TJP2, also known as ZO-2) and bile acid Coenzyme A: amino acid N-acyltransferase (encoded by BAAT).

Mouse (Murine) Tight Junction Protein 2 (Zona Occludens 2) (TJP2) interaction partners

  1. Based on results obtained in cultured epithelial cells transfected with ZO-2 mutated at a MET target lysine residue.

  2. Podocyte-specific deletion of the ZO-2 gene did not cause overt defects; however, double knockout of ZO-1 and ZO-2 genes accelerated the defects observed in ZO-1 knockout mice. These results suggest that ZO-2 plays supportive roles in the ZO-1-dependent regulation of podocyte filtration barrier.

  3. In the present study, we found that the protein level of ZO-2, a scaffolding tight junction protein, decreased in the bladder of OVX mice indicating a possible role in overactive bladder.

  4. Expression of Podocalyxin, which positively regulates the formation of microvilli and the apical membrane, is repressed in embryoid bodies lacking both ZO-1 and ZO-2 and this correlates with an aberrant submembranous localization of Ezrin.

  5. SNX27 associates with ZO-2 and modulates the epithelial tight junction.

  6. ZO-2 protects against podocyte dysfunction induced by adreiamycin. This action is regulated by ZO-2-mediated inhibition of the Wnt/beta-catenin signaling pathway

  7. the first PDZ domain of ZO-2 interacts with YAP2 to form complex; ZO-2 facilitates both nuclear translocation of YAP2 & pro-apoptotic function of YAP2; these activities of ZO-2 are PDZ-domain-dependent

  8. Male ZO-2 chimeras show reduced fertility and pathological changes in the testis. Lanthanum tracer experiments show a compromised blood-testis barrier.

  9. nuclear ZO-2 is present in epithelial and endothelial cells, particularly in response to environmental stress conditions

  10. ZO-1 and ZO-2 function redundantly to some extent in junction formation/epithelial polarization but they are not functionally identical

  11. These findings indicate that ZO-1 and ZO-2 can independently determine whether and where claudins are polymerized.

  12. These results suggest novel roles for ZO proteins as Src/Csk scaffolds potentially involved in the regulation of Src transformation.

  13. Early embryonic lethality of mice lacking Tjp2, but not Tjp3, reveal critical and nonredundant roles for individual zonula occludens proteins in mammalian development.

  14. analysis of ZO-1- and ZO-2-dependent integration of myosin-2 to epithelial zonula

  15. Quantitative analysis of trophectoderm tight junctions in ZO-2-deficient embryos revealed increased assembly of ZO-1 but not occludin, indicating ZO protein redundancy as a compensatory mechanism contributing to the mild phenotype observed.

  16. ZO-2 play pivotal roles in the final establishment of the belt-like adherens junctions (zonula adherens), followed by the formation of the belt-like TJs (zonula occludens) with paracellular barrier function

Zebrafish Tight Junction Protein 2 (Zona Occludens 2) (TJP2) interaction partners

  1. analysis of tissue distribution and developmental expression of tjp1/zo-1, tjp2/zo-2 and tjp3/zo-3 in the zebrafish, Danio rerio

TJP2 Antigen Profile

Protein Summary

This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with TJP2

  • tight junction protein 2 (TJP2) antibody
  • tight junction protein 2 (Tjp2) antibody
  • tight junction protein 2 L homeolog (tjp2.L) antibody
  • tight junction protein 2b (zona occludens 2) (tjp2b) antibody
  • C9DUPq21.11 antibody
  • DFNA51 antibody
  • DUP9q21.11 antibody
  • tjp2 antibody
  • wu:fb62b09 antibody
  • x104 antibody
  • zgc:92094 antibody
  • zo-2 antibody
  • zo2 antibody

Protein level used designations for TJP2

Friedreich ataxia region gene X104 (tight junction protein ZO-2) , tight junction protein ZO-2 , zona occludens 2 , zonula occludens protein 2 , tight junction protein 2 (zona occludens 2) , Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2) , zona occludens protein 2 , tight junction protein 2 L homeolog , fb62b09 , tight junction protein 2b , tjp2.2 , zo-2.2

GENE ID SPECIES
9414 Homo sapiens
100229218 Taeniopygia guttata
21873 Mus musculus
115769 Rattus norvegicus
395751 Gallus gallus
403854 Canis lupus familiaris
407101 Bos taurus
100729549 Cavia porcellus
779228 Xenopus laevis
436639 Danio rerio
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