anti-Transcription Factor EB (TFEB) Antibodies

Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Additionally we are shipping Transcription Factor EB Proteins (4) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TFEB 7942 P19484
TFEB 21425 Q9R210
TFEB 316214  
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Top anti-Transcription Factor EB Antibodies at antibodies-online.com

Showing 10 out of 138 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-TFEB Antibody Titration: 0.2-1 ug/mlPositive Control: PANC1 cell lysate WB Suggested Anti-TFEB  Antibody Titration: 0.2-1 µg/mL  Positive Control: PANC1 cell lysate 100 μL 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated ELISA, WB ABIN184741 staining (1 ug/ml) of NIH-3T3 lysate (RIPA buffer, 30 ug total protein per lane).  Primary incubated for 1 hour.  Detected by western blot using chemiluminescence. ABIN184741 (0.5 µg/mL) staining of Human Thymus lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg 6 to 7 Days
$429.84
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-TFEB Antibody Titration:  2.5ug/ml  ELISA Titer:  1:312500  Positive Control:  HepG2 cell lysate Host:  Mouse  Target Name:  TFE3  Sample Tissue:  Mouse Brain  Antibody Dilution:  1ug/ml 100 μL 2 to 3 Days
$229.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-TFEB Antibody Titration:  0.2-1 ug/ml  Positive Control:  HepG2 cell lysate Host:  Rabbit  Target Name:  TFEB  Sample Tissue:  Human Lung Tumor  Antibody Dilution:  1.0ug/ml 100 μL 2 to 3 Days
$319.00
Details
Cow Rabbit Un-conjugated WB Western blot analysis of TFEB expression in A549 (A), NIH3T3 (B), H9C2 (C) whole cell lysates. 200 μL 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from mouse lung/mouse muscle cells, using TFEB Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using TFEB Antibody. The picture on the right is treated with the synthesized peptide. 100 μg 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated WB WB Image Sample(30 ug whole cell lysate) A:293T 10% SDS PAGE antibody diluted at 1:1000 100 μL 3 to 4 Days
$466.18
Details
Human Rabbit Un-conjugated ELISA, IHC, WB Western Blot (WB) analysis of Mouse Kidney lysis using TFEB antibody. 100 μL Available
$363.46
Details
Bat Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$493.17
Details
Bat Goat Un-conjugated ELISA, WB 100 μg 11 to 14 Days
$610.50
Details

Top referenced anti-Transcription Factor EB Antibodies

  1. Human Polyclonal TFEB Primary Antibody for ChIP, ELISA - ABIN249518 : Kuiper, Schepens, Thijssen, van Asseldonk, van den Berg, Bridge, Schuuring, Schoenmakers, van Kessel: Upregulation of the transcription factor TFEB in t(6;11)(p21;q13)-positive renal cell carcinomas due to promoter substitution. in Human molecular genetics 2003 (PubMed)
    Show all 7 Pubmed References

  2. Human Polyclonal TFEB Primary Antibody for ELISA, WB - ABIN408704 : Davis, Kim, Ozsolak, Widlund, Rozenblatt-Rosen, Granter, Du, Fletcher, Denny, Lessnick, Linehan, Kung, Fisher: Oncogenic MITF dysregulation in clear cell sarcoma: defining the MiT family of human cancers. in Cancer cell 2006 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal TFEB Primary Antibody for WB - ABIN6149043 : Bhatelia, Singh, Prajapati, Sripada, Roy, Singh: MITA modulated autophagy flux promotes cell death in breast cancer cells. in Cellular signalling 2018 (PubMed)

  4. Dog (Canine) Polyclonal TFEB Primary Antibody for ELISA, WB - ABIN546846 : Huan, Sashital, Hailemariam, Kelly, Roman: Renal carcinoma-associated transcription factors TFE3 and TFEB are leukemia inhibitory factor-responsive transcription activators of E-cadherin. in The Journal of biological chemistry 2005 (PubMed)

  5. Human Monoclonal TFEB Primary Antibody for IF, ELISA - ABIN563503 : Ju, Yan, Liu, Li, Sheng, Zhang, Li, Liang, Huang, Liu, Zhao, Zhang, Zou, Du, Zhong, Zhou, Yang, Lu, Tian, Li, Zhang, Jin, Jiang: Neuraminidase of Influenza A Virus Binds Lysosome-Associated Membrane Proteins Directly and Induces Lysosome Rupture. in Journal of virology 2015 (PubMed)

  6. Human Polyclonal TFEB Primary Antibody for IF, WB - ABIN6225754 : Luo, Ma, Yang, Wang, Zhang, Zhang, Liu, Liu: TFEB regulates PER3 expression via glucose-dependent effects on CLOCK/BMAL1. in The international journal of biochemistry & cell biology 2017 (PubMed)

  7. Human Polyclonal TFEB Primary Antibody for IP, WB - ABIN4358632 : Roczniak-Ferguson, Petit, Froehlich, Qian, Ky, Angarola, Walther, Ferguson: The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis. in Science signaling 2012 (PubMed)

More Antibodies against Transcription Factor EB Interaction Partners

Human Transcription Factor EB (TFEB) interaction partners

  1. altering the nuclear export of HLH-30/TFEB can regulate autophagy.

  2. In this review, the authors delineate the current understanding of how TFEB dysregulation is involved in neurodegeneration. Because TFEB is a central node in defining autophagy activation status, efforts at understanding the basis for TFEB dysfunction are yielding insights into how TFEB might be targeted for therapeutic application, which may represent an exciting opportunity for the development of a treatment modality.

  3. The activity of TFEB in chondrocyte is involved in OA development.

  4. This study unveils a positive role of TRIM37 in regulating the MTORC1-TFEB axis.

  5. TFEB acetylation plays an important role in determining its transcriptional activity, lysosomal function and autophagy in cancer cells.

  6. our results demonstrated that procyanidin B2 attenuated FFAs-induced hepatic steatosis through regulating TFEB-mediated lysosomal pathway and redox state, which had important implications that modulation of TFEB might be a potential therapeutic strategy for hepatic steatosis and procyanidin B2 could represent a promising novel agent in the prevention and treatment of non-alcoholic fatty liver disease (NAFLD).

  7. PR137B-knockout cells exhibited defective autophagy and an expanded lysosome compartment, similar to Rag-knockout cells. Like zebrafish RagA mutants, GPR137B-mutant zebrafish had upregulated TFEB target gene expression and an expanded lysosome compartment in microglia.

  8. This study unravels the role of calcineurin in the dephosphorylation of TFEB as well as the involvement of TFEB in lysosomal exocytosis, respectively.

  9. nutrient stress induces the protein expression of both MITF and TFEB in ARPE-19 cells.

  10. Results indicate that transcription factor EB modulates amyloid beta production not only by increasing alpha-secretase processing of amyloid beta precursor protein through ADAM10 upregulation but also by augmenting beta-C-terminal fragment levels possibly via altered proteasome-mediated catabolism.

  11. Our data identify TFEB as not only a potential target for preventing alpha-synuclein transmission, but also a critical factor for iron-induced alpha-synuclein aggregation and transmission

  12. TFEB was activated shortly after Acinetobacter baumannii infection, and is required for its persistence within host cells.

  13. TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins.

  14. data on TFEB nucleo-cytoplasmic shuttling suggest an unpredicted role of mTOR in nuclear export.

  15. The transcription factor EB (TFEB) nuclear export signal (NES) integrates carbon (glucose) and nitrogen (amino acid) availability by controlling TFEB flux through a nuclear import-export cycle.

  16. TFEB knockdown reduces invasion and migration of cancer cells, likely through lysosomal regulation. Taken together, TFEB influences cell invasion and migration of oral squamous cell carcinomas.

  17. Akt phosphorylates TFEB at Ser467 and represses TFEB nuclear translocation independently of mechanistic target of rapamycin complex 1, a known TFEB inhibitor. Pharmacological inhibition of Akt promotes cellular clearance in cells from patients with a variety of lysosomal diseases.

  18. these data suggest that the TFEB/TMEM55B/JIP4 pathway coordinates lysosome movement in response to a variety of stress conditions.

  19. Data suggest that the effects of Alpha-TFEB gene fusion are specific in renal cell carcinoma, which results in the overexpression of a native TFEB protein and then promotes cell canceration.

  20. MAP4K3 is identified as an amino acid-dependent regulator of autophagy through its phosphorylation of transcription factor EB (TFEB), a transcriptional activator of autophagy.

Mouse (Murine) Transcription Factor EB (TFEB) interaction partners

  1. IFNG utilizes the PPP3-TFEB signaling axis for inducing autophagy and regulating mycobacterial growth.

  2. Disruption of the dynamics by enforced expression of TFEB in high fat diet-fed mice at the peaks of MTORC1 activation restored lysosome function.

  3. our results demonstrated that procyanidin B2 attenuated FFAs-induced hepatic steatosis through regulating TFEB-mediated lysosomal pathway and redox state, which had important implications that modulation of TFEB might be a potential therapeutic strategy for hepatic steatosis and procyanidin B2 could represent a promising novel agent in the prevention and treatment of non-alcoholic fatty liver disease (NAFLD).

  4. The effect of SIK2 on autophagic flux occurs before the regulation of TFEB protein levels, suggesting different mechanisms whereby SIK2 stimulates autophagy.

  5. suggests that astrocytic TFEB plays a functional role in modulating extracellular tau and the propagation of neuronal tau pathology in tauopathies such as Alzheimer's disease.

  6. TFEB functions cell-autonomously through PUMA induction and Bax-Bak activation to promote programmed cell death of a subset of premyelinating oligodendrocytes, allowing selective elimination of oligodendrocytes in normally unmyelinated brain regions.

  7. Endothelial TFEB functions as a positive regulator of postischemic angiogenesis. TFEB activates AMPKalpha signaling and upregulates autophagy.

  8. TFEB is critical for resistance to intestinal epithelial cell injury, potentially mediated by APOA1

  9. The amino acid-sensing pathway consisting of Lamtor1, mTORC1, and TFEB is involved in the regulation of innate immune responses.

  10. expression of multiple genes implicated in cell cycle control is altered in TFEB/TFE3 DKOs, revealing a previously unrecognized role of TFEB and TFE3 in the regulation of cell cycle checkpoints in response to stress.

  11. Acute exercise provokes TFEB expression and activation in a PGC-1alpha-dependent manner and suggest that TFEB, along with PGC-1alpha, is an important regulator of mitochondrial biogenesis in muscle as a result of exercise.

  12. TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins.

  13. Data show that during testicular development, transcriptional factor EB (TFEB) expression was rapidly increased in the testes at the period of 7 days post-partum (dpp) to 14 dpp.

  14. Enhancing lysosomal biogenesis and autophagic flux by activating the TFEB protects against cadmium-induced neurotoxicity.

  15. TFEB and TFE3 collaborate with each other in activated macrophages and microglia to promote efficient autophagy induction, increased lysosomal biogenesis, and transcriptional upregulation of numerous proinflammatory cytokines

  16. Fcgamma receptor activation causes nuclear translocation of TFEB, a transcription factor that boosts expression of lysosome genes. Indeed, Fc receptor activation is accompanied by increased expression of specific lysosomal proteins. Remarkably, TFEB silencing represses the Fcgamma-receptor-mediated enhancements in degradation and bacterial killing.

  17. These data indicate that TFE3 and TFEB play a cooperative, rather than redundant, role in the control of the adaptive response of whole-body metabolism to environmental cues such as diet and physical exercise.

  18. TFEB regulates PER3 expression via glucose-dependent effects on CLOCK/BMAL1

  19. These data reveal a novel mechanism of TFEB regulation by MTORC1 essential for lysosomal biogenesis.

  20. These results suggest that TFEB expression in the striatum of HDQ175/Q7 mice stimulates autophagy and lysosome activity.

Zebrafish Transcription Factor EB (TFEB) interaction partners

  1. Loss of Tfeb function is sufficient to restore myelination in RagA mutants, indicating that hyperactive Tfeb represses myelination. Conversely, tfeb(-/-) single mutants exhibit ectopic myelin, further indicating that Tfeb represses myelination during development.

  2. The zebrafish genome contain two mitf (mitfa and mitfb), two tfe3 (tfe3a and tfe3b), and single tfeb and tfec genes.

Transcription Factor EB (TFEB) Antigen Profile

Protein Summary

Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T- cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta.

Gene names and symbols associated with TFEB

  • transcription factor EB (TFEB) antibody
  • transcription factor EB (tfeb) antibody
  • transcription factor EB (Tfeb) antibody
  • ALPHATFEB antibody
  • bHLHe35 antibody
  • MGC145796 antibody
  • Tcfeb antibody
  • TFEB antibody

Protein level used designations for TFEB

transcription factor EB , transcription factor EB-like , T-cell transcription factor EB , class E basic helix-loop-helix protein 35

GENE ID SPECIES
100066433 Equus caballus
694214 Macaca mulatta
748433 Pan troglodytes
780105 Xenopus (Silurana) tropicalis
100137208 Papio anubis
100449854 Pongo abelii
100583940 Nomascus leucogenys
7942 Homo sapiens
21425 Mus musculus
562289 Danio rerio
419922 Gallus gallus
609046 Canis lupus familiaris
100157940 Sus scrofa
510032 Bos taurus
100328714 Oryctolagus cuniculus
316214 Rattus norvegicus
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