Transcription Factor EB Proteins (TFEB)

Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Additionally we are shipping Transcription Factor EB Antibodies (157) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TFEB 7942 P19484
TFEB 21425 Q9R210
Rat TFEB TFEB 316214  
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Top Transcription Factor EB Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,626.73
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,626.73
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Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Log in to see 11 Days
$291.50
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Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$338.33
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TFEB Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Top referenced Transcription Factor EB Proteins

  1. Human TFEB Protein expressed in Escherichia coli (E. coli) - ABIN2733467 : Song, Sun, Peluso, Zeng, Yu, Lu, Xu, Wang, Liu, Huang, Chen, Durairajan, Zhang, Zhou, Zhang, Lu, Ballabio, Medina, Guo, Li: A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition. in Autophagy 2016 (PubMed)

More Proteins for Transcription Factor EB (TFEB) Interaction Partners

Human Transcription Factor EB (TFEB) interaction partners

  1. Our data identify TFEB as not only a potential target for preventing alpha-synuclein transmission, but also a critical factor for iron-induced alpha-synuclein aggregation and transmission

  2. TFEB was activated shortly after Acinetobacter baumannii infection, and is required for its persistence within host cells.

  3. TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins.

  4. data on TFEB nucleo-cytoplasmic shuttling suggest an unpredicted role of mTOR in nuclear export.

  5. The transcription factor EB (TFEB) nuclear export signal (NES) integrates carbon (glucose) and nitrogen (amino acid) availability by controlling TFEB flux through a nuclear import-export cycle.

  6. TFEB knockdown reduces invasion and migration of cancer cells, likely through lysosomal regulation. Taken together, TFEB influences cell invasion and migration of oral squamous cell carcinomas.

  7. Akt phosphorylates TFEB at Ser467 and represses TFEB nuclear translocation independently of mechanistic target of rapamycin complex 1, a known TFEB inhibitor. Pharmacological inhibition of Akt promotes cellular clearance in cells from patients with a variety of lysosomal diseases.

  8. these data suggest that the TFEB/TMEM55B/JIP4 pathway coordinates lysosome movement in response to a variety of stress conditions.

  9. Data suggest that the effects of Alpha-TFEB gene fusion are specific in renal cell carcinoma, which results in the overexpression of a native TFEB protein and then promotes cell canceration.

  10. MAP4K3 is identified as an amino acid-dependent regulator of autophagy through its phosphorylation of transcription factor EB (TFEB), a transcriptional activator of autophagy.

  11. Overexpression of TFEB is associated with Breast Cancer.

  12. Results identify cigarette smoke (CS)-induced accumulation of TFEB in aggresome-bodies as a specific novel mechanism for CS-mediated autophagy-impairment and resulting aggresome-formation and emphysema progression.

  13. This study reveals a critical link between two keys factors in tumourigenesis and autophagy, and suggests a potential important role of p53-TFEB signaling axis in lung cancer.

  14. Taken together, these data demonstrate that ATO induces osteosarcoma cell death via inducing excessive autophagy, which is mediated through the ROS-TFEB pathway. The present study provides a new anti-tumor mechanism of ATO treatment in osteosarcoma.

  15. cellular vacuolization, represents a condition of profound lysosome stress, and cells sense and respond to this stress by facilitating mTOR-dependent TFEB nucleus translocation in an effort to restore lysosome homeostasis.

  16. TFEB and TFE3 collaborate with each other in activated macrophages and microglia to promote efficient autophagy induction, increased lysosomal biogenesis, and transcriptional upregulation of numerous proinflammatory cytokines

  17. TFEB is affected by a novel curcumin analog in vitro and in vivo independent of MTOR inhibition

  18. TFEB regulates PER3 expression via glucose-dependent effects on CLOCK/BMAL1

  19. These data reveal a novel mechanism of TFEB regulation by MTORC1 essential for lysosomal biogenesis.

  20. Data suggest that transcription factor EB (TFEB) is a protective transcription factor against endothelial cell inflammation and a potential target for treating atherosclerosis and associated cardiovascular diseases.

Mouse (Murine) Transcription Factor EB (TFEB) interaction partners

  1. The amino acid-sensing pathway consisting of Lamtor1, mTORC1, and TFEB is involved in the regulation of innate immune responses.

  2. expression of multiple genes implicated in cell cycle control is altered in TFEB/TFE3 DKOs, revealing a previously unrecognized role of TFEB and TFE3 in the regulation of cell cycle checkpoints in response to stress.

  3. Acute exercise provokes TFEB expression and activation in a PGC-1alpha-dependent manner and suggest that TFEB, along with PGC-1alpha, is an important regulator of mitochondrial biogenesis in muscle as a result of exercise.

  4. TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins.

  5. Data show that during testicular development, transcriptional factor EB (TFEB) expression was rapidly increased in the testes at the period of 7 days post-partum (dpp) to 14 dpp.

  6. Enhancing lysosomal biogenesis and autophagic flux by activating the TFEB protects against cadmium-induced neurotoxicity.

  7. TFEB and TFE3 collaborate with each other in activated macrophages and microglia to promote efficient autophagy induction, increased lysosomal biogenesis, and transcriptional upregulation of numerous proinflammatory cytokines

  8. Fcgamma receptor activation causes nuclear translocation of TFEB, a transcription factor that boosts expression of lysosome genes. Indeed, Fc receptor activation is accompanied by increased expression of specific lysosomal proteins. Remarkably, TFEB silencing represses the Fcgamma-receptor-mediated enhancements in degradation and bacterial killing.

  9. These data indicate that TFE3 and TFEB play a cooperative, rather than redundant, role in the control of the adaptive response of whole-body metabolism to environmental cues such as diet and physical exercise.

  10. TFEB regulates PER3 expression via glucose-dependent effects on CLOCK/BMAL1

  11. These data reveal a novel mechanism of TFEB regulation by MTORC1 essential for lysosomal biogenesis.

  12. These results suggest that TFEB expression in the striatum of HDQ175/Q7 mice stimulates autophagy and lysosome activity.

  13. A functional role for TFEB downregulation in impaired autophagy completion with JAK2 knockdown is implied by the coincident downregulation in TFEB-regulated genes and a restoration of autophagic flux and podocyte permselectivity by TFEB overexpression.

  14. Tfe3 and Tfeb are required for the induced expression of Ppargamma2 and subsequently for adipogenic genes.

  15. our data indicate that PPAR-alpha mediates antimicrobial responses to mycobacterial infection by inducing TFEB and lipid catabolism.

  16. Consistent with reduced transcription factor EB (TFEB) activity, accumulation of phosphorylated TFEB in STUB1-deficient cells resulted in reduced autophagy and reduced mitochondrial biogenesis. These studies reveal that the ubiquitin-proteasome pathway participates in regulating autophagy and lysosomal functions by regulating the activity of TFEB.

  17. These findings identify TFEB as a critical mediator of the beneficial effects of exercise on metabolism.

  18. Consistent with reduced mTOR activity and increased TFEB levels, loss of C9orf72 enhances autophagic flux, suggesting that C9orf72 is a negative regulator of autophagy

  19. these results uncover a potent role for TFEB-mediated autophagy in the pathogenesis of Cd-induced neurotoxicity, suggesting that control of the autophagic pathway by melatonin might provide an important clue for exploring potential targets for novel therapeutics of Cd-induced neurotoxicity.

  20. TFEB mediated autophagy is crucial for protection against lipopolysaccharide induced myocardial injury particularly in aging senescent heart.

Zebrafish Transcription Factor EB (TFEB) interaction partners

  1. Loss of Tfeb function is sufficient to restore myelination in RagA mutants, indicating that hyperactive Tfeb represses myelination. Conversely, tfeb(-/-) single mutants exhibit ectopic myelin, further indicating that Tfeb represses myelination during development.

  2. The zebrafish genome contain two mitf (mitfa and mitfb), two tfe3 (tfe3a and tfe3b), and single tfeb and tfec genes.

Transcription Factor EB (TFEB) Protein Profile

Protein Summary

Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T- cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta.

Gene names and symbols associated with Transcription Factor EB Proteins (TFEB)

  • transcription factor EB (TFEB)
  • transcription factor EB (tfeb)
  • transcription factor EB (Tfeb)
  • ALPHATFEB protein
  • bHLHe35 protein
  • MGC145796 protein
  • Tcfeb protein
  • TFEB protein

Protein level used designations for Transcription Factor EB Proteins (TFEB)

transcription factor EB , transcription factor EB-like , T-cell transcription factor EB , class E basic helix-loop-helix protein 35

GENE ID SPECIES
100066433 Equus caballus
694214 Macaca mulatta
748433 Pan troglodytes
780105 Xenopus (Silurana) tropicalis
100137208 Papio anubis
100449854 Pongo abelii
100583940 Nomascus leucogenys
7942 Homo sapiens
21425 Mus musculus
562289 Danio rerio
419922 Gallus gallus
609046 Canis lupus familiaris
100157940 Sus scrofa
510032 Bos taurus
100328714 Oryctolagus cuniculus
316214 Rattus norvegicus
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