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Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Additionally we are shipping Transcription Factor EB Antibodies (154) and and many more products for this protein.
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Human TFEB Protein expressed in Escherichia coli (E. coli) - ABIN2733467
Song, Sun, Peluso, Zeng, Yu, Lu, Xu, Wang, Liu, Huang, Chen, Durairajan, Zhang, Zhou, Zhang, Lu, Ballabio, Medina, Guo, Li: A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition. in Autophagy 2016
Results identify cigarette smoke (CS)-induced accumulation of TFEB in aggresome-bodies as a specific novel mechanism for CS-mediated autophagy-impairment and resulting aggresome-formation and emphysema progression.
This study reveals a critical link between two keys factors in tumourigenesis and autophagy, and suggests a potential important role of p53 (show TP53 Proteins)-TFEB signaling axis in lung cancer.
Taken together, these data demonstrate that ATO induces osteosarcoma cell death via inducing excessive autophagy, which is mediated through the ROS (show ROS1 Proteins)-TFEB pathway. The present study provides a new anti-tumor mechanism of ATO treatment in osteosarcoma.
cellular vacuolization, represents a condition of profound lysosome stress, and cells sense and respond to this stress by facilitating mTOR (show FRAP1 Proteins)-dependent TFEB nucleus translocation in an effort to restore lysosome homeostasis.
TFEB and TFE3 (show TFE3 Proteins) collaborate with each other in activated macrophages and microglia to promote efficient autophagy induction, increased lysosomal biogenesis, and transcriptional upregulation of numerous proinflammatory cytokines
TFEB is affected by a novel curcumin analog in vitro and in vivo independent of MTOR (show FRAP1 Proteins) inhibition
TFEB regulates PER3 expression via glucose-dependent effects on CLOCK/BMAL1 (show ARNTL Proteins)
These data reveal a novel mechanism of TFEB regulation by MTORC1 essential for lysosomal biogenesis.
Data suggest that transcription factor EB (TFEB) is a protective transcription factor against endothelial cell inflammation and a potential target for treating atherosclerosis and associated cardiovascular diseases.
Both Danon Disease and glycogen (show GYS1 Proteins) storage disease type II show accumulation and altered localization of VPS15 in autophagy-incompetent fibers. However, TFEB displays a different pattern between these two lysosomal storage diseases
Fcgamma receptor activation causes nuclear translocation of TFEB, a transcription factor that boosts expression of lysosome genes. Indeed, Fc receptor (show FCGRT Proteins) activation is accompanied by increased expression of specific lysosomal proteins. Remarkably, TFEB silencing represses the Fcgamma-receptor-mediated enhancements in degradation and bacterial killing.
These data indicate that TFE3 (show TFE3 Proteins) and TFEB play a cooperative, rather than redundant, role in the control of the adaptive response of whole-body metabolism to environmental cues such as diet and physical exercise.
These results suggest that TFEB expression in the striatum of HDQ175/Q7 mice stimulates autophagy and lysosome activity.
A functional role for TFEB downregulation in impaired autophagy completion with JAK2 (show JAK2 Proteins) knockdown is implied by the coincident downregulation in TFEB-regulated genes and a restoration of autophagic flux and podocyte permselectivity by TFEB overexpression.
Tfe3 (show TFE3 Proteins) and Tfeb are required for the induced expression of Ppargamma2 (show PPARG Proteins) and subsequently for adipogenic genes.
our data indicate that PPAR-alpha (show PPARA Proteins) mediates antimicrobial responses to mycobacterial infection by inducing TFEB and lipid catabolism.
Consistent with reduced transcription factor EB (TFEB) activity, accumulation of phosphorylated TFEB in STUB1 (show STUB1 Proteins)-deficient cells resulted in reduced autophagy and reduced mitochondrial biogenesis. These studies reveal that the ubiquitin-proteasome pathway participates in regulating autophagy and lysosomal functions by regulating the activity of TFEB.
The zebrafish genome contain two mitf (mitfa (show MITF Proteins) and mitfb (show MITF Proteins)), two tfe3 (show TFE3 Proteins) (tfe3a and tfe3b), and single tfeb and tfec (show TFEC Proteins) genes.
Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T- cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta.
transcription factor EB
, transcription factor EB-like
, T-cell transcription factor EB
, class E basic helix-loop-helix protein 35