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Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Additionally we are shipping Transcription Factor EB Antibodies (155) and and many more products for this protein.
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Human TFEB Protein expressed in Escherichia coli (E. coli) - ABIN2733467
Song, Sun, Peluso, Zeng, Yu, Lu, Xu, Wang, Liu, Huang, Chen, Durairajan, Zhang, Zhou, Zhang, Lu, Ballabio, Medina, Guo, Li: A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition. in Autophagy 2016
TFEB knockdown reduces invasion and migration of cancer cells, likely through lysosomal regulation. Taken together, TFEB influences cell invasion and migration of oral squamous cell carcinomas.
Akt (show AKT1 Proteins) phosphorylates TFEB at Ser467 and represses TFEB nuclear translocation independently of mechanistic target of rapamycin (show FRAP1 Proteins) complex 1, a known TFEB inhibitor. Pharmacological inhibition of Akt (show AKT1 Proteins) promotes cellular clearance in cells from patients with a variety of lysosomal diseases.
these data suggest that the TFEB/TMEM55B/JIP4 (show SPAG9 Proteins) pathway coordinates lysosome movement in response to a variety of stress conditions.
Data suggest that the effects of Alpha-TFEB gene fusion are specific in renal cell carcinoma (show MOK Proteins), which results in the overexpression of a native TFEB protein and then promotes cell canceration.
MAP4K3 (show MAP4K3 Proteins) is identified as an amino acid-dependent regulator of autophagy through its phosphorylation of transcription factor EB (TFEB), a transcriptional activator of autophagy.
Overexpression of TFEB is associated with Breast Cancer.
Results identify cigarette smoke (CS)-induced accumulation of TFEB in aggresome-bodies as a specific novel mechanism for CS-mediated autophagy-impairment and resulting aggresome-formation and emphysema progression.
This study reveals a critical link between two keys factors in tumourigenesis and autophagy, and suggests a potential important role of p53 (show TP53 Proteins)-TFEB signaling axis in lung cancer.
Taken together, these data demonstrate that ATO induces osteosarcoma cell death via inducing excessive autophagy, which is mediated through the ROS (show ROS1 Proteins)-TFEB pathway. The present study provides a new anti-tumor mechanism of ATO treatment in osteosarcoma.
cellular vacuolization, represents a condition of profound lysosome stress, and cells sense and respond to this stress by facilitating mTOR (show FRAP1 Proteins)-dependent TFEB nucleus translocation in an effort to restore lysosome homeostasis.
Enhancing lysosomal biogenesis and autophagic flux by activating the TFEB protects against cadmium-induced neurotoxicity.
TFEB and TFE3 (show TFE3 Proteins) collaborate with each other in activated macrophages and microglia to promote efficient autophagy induction, increased lysosomal biogenesis, and transcriptional upregulation of numerous proinflammatory cytokines
Fcgamma receptor activation causes nuclear translocation of TFEB, a transcription factor that boosts expression of lysosome genes. Indeed, Fc receptor (show FCGRT Proteins) activation is accompanied by increased expression of specific lysosomal proteins. Remarkably, TFEB silencing represses the Fcgamma-receptor-mediated enhancements in degradation and bacterial killing.
These data indicate that TFE3 (show TFE3 Proteins) and TFEB play a cooperative, rather than redundant, role in the control of the adaptive response of whole-body metabolism to environmental cues such as diet and physical exercise.
TFEB regulates PER3 expression via glucose-dependent effects on CLOCK/BMAL1 (show ARNTL Proteins)
These data reveal a novel mechanism of TFEB regulation by MTORC1 essential for lysosomal biogenesis.
These results suggest that TFEB expression in the striatum of HDQ175/Q7 mice stimulates autophagy and lysosome activity.
A functional role for TFEB downregulation in impaired autophagy completion with JAK2 (show JAK2 Proteins) knockdown is implied by the coincident downregulation in TFEB-regulated genes and a restoration of autophagic flux and podocyte permselectivity by TFEB overexpression.
Tfe3 (show TFE3 Proteins) and Tfeb are required for the induced expression of Ppargamma2 (show PPARG Proteins) and subsequently for adipogenic genes.
our data indicate that PPAR-alpha (show PPARA Proteins) mediates antimicrobial responses to mycobacterial infection by inducing TFEB and lipid catabolism.
The zebrafish genome contain two mitf (mitfa (show MITF Proteins) and mitfb (show MITF Proteins)), two tfe3 (show TFE3 Proteins) (tfe3a and tfe3b), and single tfeb and tfec (show TFEC Proteins) genes.
Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T- cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta.
transcription factor EB
, transcription factor EB-like
, T-cell transcription factor EB
, class E basic helix-loop-helix protein 35