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TFEC encodes a member of the micropthalmia (MiT) family of basic helix-loop-helix leucine zipper transcription factors. Additionally we are shipping Transcription Factor EC Proteins (10) and and many more products for this protein.
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Human Polyclonal TFEC Primary Antibody for WB - ABIN1881878
Chung, Kim, Kawamoto: TFEC can function as a transcriptional activator of the nonmuscle myosin II heavy chain-A gene in transfected cells. in Biochemistry 2001
Show all 5 Pubmed References
Human Polyclonal TFEC Primary Antibody for ELISA, WB - ABIN249519
Yasumoto, Shibahara: Molecular cloning of cDNA encoding a human TFEC isoform, a newly identified transcriptional regulator. in Biochimica et biophysica acta 1997
Mouse (Murine) Polyclonal TFEC Primary Antibody for ELISA - ABIN547967
Davis, Kim, Ozsolak, Widlund, Rozenblatt-Rosen, Granter, Du, Fletcher, Denny, Lessnick, Linehan, Kung, Fisher: Oncogenic MITF dysregulation in clear cell sarcoma: defining the MiT family of human cancers. in Cancer cell 2006
The zebrafish genome contain two mitf (mitfa and mitfb), two tfe3 (tfe3a and tfe3b), and single tfeb and tfec genes.
Data show that expression of Mitf rescues pigmentation fully in zebrafish, but only partially in Sox10-mutant mice.
Two alternatively spliced TFEC isoforms have been found to be sequence-specific transcriptional activators of the nonmuscle myosin II heavy chain-A gene in transfected cells.
Tfec transcribes IL-4 receptor alpha expression to promote M2 programming in macrophages
Data indicate that FOS, SPI1, KLF10, TFEC, and PRDM16 show robust transcriptional cross-regulation and are often associated with osteoclastogenesis.
Transcription factor EC, along with several other transcription factors, is a Stat6-dependent target of IL-4.
This gene encodes a member of the micropthalmia (MiT) family of basic helix-loop-helix leucine zipper transcription factors. MiT transcription factors regulate the expression of target genes by binding to E-box recognition sequences as homo- or heterodimers, and play roles in multiple cellular processes including survival, growth and differentiation. The encoded protein is a transcriptional activator of the nonmuscle myosin II heavy chain-A gene, and may also co-regulate target genes in osteoclasts as a heterodimer with micropthalmia-associated transcription factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
transcription factor EC
, class E basic helix-loop-helix protein 34