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TRA2B encodes a nuclear protein which functions as sequence-specific serine/arginine splicing factor which plays a role in mRNA processing, splicing patterns, and gene expression. Additionally we are shipping TRA2B Antibodies (53) and TRA2B Kits (5) and many more products for this protein.
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Findings demonstrate that Tra2b is upregulated in non-small cell lung cancer (NSCLC) and is associated with poor prognosis. Furthermore, Tra2b was identified as a direct target of miR (show MLXIP Proteins)-335. These results indicate that the interaction between miR (show MLXIP Proteins)-335 and Tra2b may play a vital role in the pathogenesis of NSCLC.
It seems that a new signaling axis, SIRT1 (show SIRT1 Proteins)-SFRS10-LPIN1 (show LPIN1 Proteins) axis, acting in the pathogenesis of alcoholic fatty liver disease exists.
that TRA2beta promotes glioma cell growth and migration, and could be a candidate for molecular targeting during gene therapy treatments of glioma
Tra2beta was significantly upregulated in prostate carcinoma, and multivariate analysis confirmed Tra2beta as an independent prognostic factor.
Overexpression of either Tra2alpha (show TRA2A Proteins) or Tra2beta results in a marked reduction in HIV-1 Gag/ Env (show ERVW-1 Proteins) expression.
Results showed that HNRNPG (show RBMX Proteins) and HTRA2 (show HTRA2 Proteins)-BETA1 were specific antagonistic regulators of ERa exon7 splicing and increased HNRNPG (show RBMX Proteins) levels were associated with improved clinical outcome of endometrial cancer through up-regulation of ERaD7 expression.
findings suggest that Tra2beta regulates apoptosis by modulating Bcl-2 (show BCL2 Proteins) expression through its competition with miR (show MLXIP Proteins)-204. This novel function may have a crucial role in tumor growth.
SRPK1 (show SRPK1 Proteins) is a regulator of Tra2beta1 splicing function and individual domains engage in considerable cross-talk, assuming novel functions with regard to RNA binding, splicing, and catalysis.
Simultaneous depletion of Tra2alpha (show TRA2A Proteins) and Tra2beta induces substantial shifts in splicing of endogenous Tra2beta target exons, and both constitutive and alternative target exons are under dual Tra2alpha (show TRA2A Proteins)-Tra2beta control.
Results indicate that transformer 2beta (Tra2beta) was involved in the tumorigenesis of NSCLC and might be a potential therapeutic target of non-small cell lung cancer (NSCLC).
results indicate that high expression level of Tra2-beta1 is responsible for increased SMN2 (show SMN1 Proteins) exon 7 inclusion in the testis of SMA (show SMN1 Proteins) mice.
Maturation of mesenteric artery smooth muscle involves TRA2beta mediated Mypt1 (show PPP1R12A Proteins) exon 24 splicing.
TRA2B has a role in regulating protein kinase C deltaI splice variant expression during 3T3L1 preadipocyte cell cycle
Tra2b regulates splicing events essential for maintaining neuronal viability during development.
TRA2B is essential for proper development of the cerebral cortex.
Sfrs10 (show SRSF2 Proteins) expression is observed in rod photoreceptors in a peri (show POSTN Proteins)-nuclear pattern.
Tra2beta, by regulating the splicing of Mypt1 (show PPP1R12A Proteins) E23, sets the sensitivity of smooth muscle to cGMP-mediated relaxation.
Normal activation of these regulated exons depends on multiple Tra2b binding sites, and significant mis (show AMH Proteins)-regulation of these exons is observed during mouse development when Tra2b is removed.
This gene encodes a nuclear protein which functions as sequence-specific serine/arginine splicing factor which plays a role in mRNA processing, splicing patterns, and gene expression. Alternative splicing results in multiple transcript variants.
transformer-2 protein homolog beta
, Splicing factor, arginine/serine-rich 10
, splicing factor, arginine/serine-rich 10
, splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila)
, transformer-2 beta
, TRA-2 beta
, transformer-2 protein homolog B
, silica-induced gene 41 protein
, serine/arginine-rich splicing factor 10
, splicing factor, arginine/serine-rich, 10